Clinical Research and Mentoring in Oral Epidemiology

口腔流行病学临床研究和指导

基本信息

项目摘要

DESCRIPTION (provided by applicant): The principal investigator's career has emphasized patient oriented research in Oral Epidemiology ranging from evaluation of risk factors, to mechanistic studies evaluating pathways, to clinical trials. Her ongoing funded research focuses on the relationships between oral conditions, inflammatory markers, nutrition and specific cardiovascular diseases. She has expanded this work to include additional cardiovascular endpoints and pregnancy outcomes, and is starting to work in diabetes. The principal investigator plans to gain additional research skills by learning Molecular and Genetic Epidemiology, which would substantially enhance her research. The principal investigator co-directs the comprehensive T32 training grant titled "New England Oral Disease Epidemiology Training Program" which is run jointly across the Harvard School of Dental Medicine and Harvard School of Public Health. The K24 award will nicely complement the T32 by providing the protected time to enhance mentoring. The principal investigator has substantial experience in mentoring trainees at different stages including students in the DMD program, clinicians seeking a doctoral degree in Epidemiology, and junior clinical faculty. These activities have resulted in a NIH small grant and a K-award headed by her mentees, and 21 peer reviewed published manuscripts with her mentees. This midcareer investigator award will allow the principal investigator to spend more time in mentoring and retaining clinicians (dentists as well as some physicians) in Oral Epidemiology research, and in helping them to become independent clinical researchers. There is a strong institutional commitment and a growing pool of clinicians seeking training and mentoring in Oral Epidemiology. The K24 will thus provide the much needed protected time and support at a critical time, which will enable her to build a strong research program in oral and systemic disease with an excellent team of patient oriented researchers, whom the principal investigator mentors. Candidate: Dr. Joshipura is an Associate Professor on Oral Health Policy and Epidemiology at the Harvard School of Dental Medicine, and an Associate Professor in Epidemiology at the Harvard School of Public Health. She received a degree in dental surgery from Bombay University, India in 1982, a MS in Biostastics from the Harvard School of Public Health in 1982, and ScD in Epidemiology from the Harvard School of Dental Medicine and Harvard School of Public Health. She has an impressive list of publications in leading journals including JAMA, New England J Med, JNCI, Annals of Internal Medicine as well as the leading dental journals. She has an impressive track record of funded research in the area of chronic diseases, pregnancy outcomes, and periodontal disease. The candidate documented the ability to provide mentoring to beginning clinical investigators by listing 21 students to whom she has provided a mentoring role. Most, but not all, of these mentored individuals where dentists. The types of research have varied widely and include molecular epidemiology, periodontal disease and blood biomarkers, fluoride, cancer, obesity, and other topics. Her long-term career goal is built a research program in oral and systemic disease with a strong team of collaborators and mentees. There are enthusiastic letters of commitment from the Dean of Harvard School of Dental Medicine (Dr. Bruce Donoff) who provides a commitment that she will be able to spend at least 50% on patient-oriented research, a letter from Dr. Douglass who recommends her without qualifications, and Dr. Stampfer who similarly enthusiastically supports Dr. Joshipura and indicates the she plays a major role in the Oral Epidemiology training program. Research Plan: With respect to the currently supported research, Dr. Joshipura provides enough information in the areas of the hypotheses and the specific aims, background, significance and rationale, preliminary studies and results, research designs and methods. Her specific aims are to relate dental status to systemic disease, to determine the extent to which the systemic disease-dental status association is mediated by inflammatory and hemostatic mediators, and by intake of dietary fiber and antioxidants. Different cohorts in which these aims can be assessed are listed and the investigator has extensive familiarity with these cohorts as is exemplified by her publications. She provides as an example of one specific project where the association between periodontal disease and tooth loss was investigated. For this specific project she lists the specific aims, background, significance and rationale, preliminary studies and results, research designs and methods. It appears that no new research to be specifically supported by this grant is listed because Dr. Joshipura feels strongly that mentees should have the freedom to choose their thesis topics as well as additional projects to the extent feasible. Mentors: The availability of beginning clinician investigators for mentoring is described and includes T32 trainees. Individuals from underrepresented racial/ethnic groups will be specifically targeted for recruitment. The types of educational experiences the candidate will provide include selecting of appropriate course work, identification of a research project and a research mentor, guidance with respect to preparing for the written and oral qualifying exams, and make the trainee familiar with administrative policies and adherence to administrative guidelines. Environment and Institutional Commitment: The letters of support indicate a commitment to the scientific development of the candidate, an adequacy of research facilities, a provision of adequate protected time, and a commitment of the institution towards career development. Budget: No concerns
描述(由申请人提供):主要研究者的职业生涯强调以患者为导向的口腔流行病学研究,范围从风险因素评估、评估途径的机制研究到临床试验。她正在进行的资助研究重点是口腔状况、炎症标志物、营养和特定心血管疾病之间的关系。她将这项工作扩展到包括其他心血管终点和妊娠结局,并开始研究糖尿病。首席研究员计划通过学习分子和遗传流行病学来获得额外的研究技能,这将大大增强她的研究。首席研究员共同指导名为“新英格兰口腔疾病流行病学培训计划”的综合 T32 培训资助项目,该项目由哈佛牙科医学院和哈佛公共卫生学院联合运营。 K24 奖项将通过提供受保护的时间来加强指导,从而很好地补充 T32。首席研究员在指导不同阶段的学员方面拥有丰富的经验,包括 DMD 项目的学生、攻读流行病学博士学位的临床医生以及初级临床教师。这些活动为她的学员带来了 NIH 小额资助和 K 奖,并与她的学员一起发表了 21 篇经过同行评审的已发表手稿。该职业中期研究者奖将使主要研究者能够花更多时间指导和留住口腔流行病学研究中的临床医生(牙医以及一些医生),并帮助他们成为独立的临床研究人员。有强有力的机构承诺和越来越多的临床医生寻求口腔流行病学方面的培训和指导。因此,K24 将在关键时刻提供急需的保护时间和支持,这将使她能够在首席研究员的指导下,与一支优秀的以患者为导向的研究人员团队建立一个强大的口腔和全身疾病研究项目。 候选人:Joshipura 博士是哈佛大学牙科医学院口腔健康政策和流行病学副教授,也是哈佛大学公共卫生学院流行病学副教授。她于 1982 年获得印度孟买大学牙科外科学位,1982 年获得哈佛大学公共卫生学院生物统计学硕士学位,并于 1982 年获得哈佛大学牙科医学院和哈佛大学公共卫生学院流行病学理学博士学位。她在《JAMA》、《新英格兰医学杂志》、《JNCI》、《内科医学年鉴》以及领先的牙科期刊等领先期刊上发表了一系列令人印象深刻的出版物。她在慢性病、妊娠结局和牙周病领域的资助研究方面拥有令人印象深刻的记录。 该候选人列出了她曾担任过指导角色的 21 名学生,证明了她为初级临床研究人员提供指导的能力。这些人中的大多数(但不是全部)都指导过牙医。研究类型多种多样,包括分子流行病学、牙周病和血液生物标志物、氟化物、癌症、肥胖和其他主题。她的长期职业目标是与强大的合作者和学员团队建立口腔和全身疾病的研究项目。哈佛牙科医学院院长(布鲁斯·多诺夫博士)热情地写了一封承诺信,承诺她将至少投入 50% 的资金用于以患者为导向的研究;道格拉斯博士在没有资格的情况下推荐她;斯坦普弗博士也同样热情地支持 Joshipura 博士,并表明她在口腔流行病学培训项目中发挥着重要作用。 研究计划:对于目前支持的研究,Joshipura博士在假设和具体目的、背景、意义和基本原理、初步研究和结果、研究设计和方法等方面提供了足够的信息。她的具体目标是将牙齿状况与全身性疾病联系起来,以确定炎症和止血介质以及膳食纤维和抗氧化剂的摄入介导全身性疾病与牙齿状况关联的程度。列出了可以评估这些目标的不同群体,并且研究者对这些群体非常熟悉,正如她的出版物所例证的那样。她提供了一个具体项目的例子,其中调查了牙周病和牙齿脱落之间的关联。对于这个具体项目,她列出了具体的目的、背景、意义和原理、初步研究和结果、研究设计和方法。 似乎没有列出这项资助特别支持的新研究,因为 Joshipura 博士强烈认为受训者应该在可行的情况下自由选择他们的论文主题以及其他项目。 导师:描述了初级临床医生研究者的指导情况,其中包括 T32 学员。来自代表性不足的种族/族裔群体的个人将成为招募的具体目标。候选人将提供的教育经历类型包括选择适当的课程作业、确定研究项目和研究导师、准备笔试和口语资格考试的指导,并使受训者熟悉行政政策并遵守行政指南。 环境和机构承诺:支持信表明对候选人科学发展的承诺、充足的研究设施、提供足够的保护时间以及机构对职业发展的承诺。 预算:不用担心

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

KAUMUDI J JOSHIPURA其他文献

KAUMUDI J JOSHIPURA的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('KAUMUDI J JOSHIPURA', 18)}}的其他基金

Oral Microbiome, Nitric oxide Metabolism, and Oral and Cardiometabolic Health
口腔微生物组、一氧化氮代谢以及口腔和心脏代谢健康
  • 批准号:
    9886231
  • 财政年份:
    2019
  • 资助金额:
    $ 15.27万
  • 项目类别:
Oral Microbiome, Nitric oxide Metabolism, and Oral and Cardiometabolic Health
口腔微生物组、一氧化氮代谢以及口腔和心脏代谢健康
  • 批准号:
    10221890
  • 财政年份:
    2019
  • 资助金额:
    $ 15.27万
  • 项目类别:
Pregnancy and EARly Lifestyle improvement Study (PEARLS)
怀孕和早期生活方式改善研究 (PEARLS)
  • 批准号:
    8538486
  • 财政年份:
    2011
  • 资助金额:
    $ 15.27万
  • 项目类别:
Periodontitis and pre-clinical diabetes
牙周炎和临床前糖尿病
  • 批准号:
    8692416
  • 财政年份:
    2010
  • 资助金额:
    $ 15.27万
  • 项目类别:
Periodontitis and pre-clinical diabetes
牙周炎和临床前糖尿病
  • 批准号:
    9085612
  • 财政年份:
    2010
  • 资助金额:
    $ 15.27万
  • 项目类别:
Periodontitis and pre-clinical diabetes
牙周炎和临床前糖尿病
  • 批准号:
    8069164
  • 财政年份:
    2010
  • 资助金额:
    $ 15.27万
  • 项目类别:
Periodontitis and pre-clinical diabetes
牙周炎和临床前糖尿病
  • 批准号:
    8843580
  • 财政年份:
    2010
  • 资助金额:
    $ 15.27万
  • 项目类别:
Periodontitis and pre-clinical diabetes
牙周炎和临床前糖尿病
  • 批准号:
    8690464
  • 财政年份:
    2010
  • 资助金额:
    $ 15.27万
  • 项目类别:
Periodontitis and pre-clinical diabetes
牙周炎和临床前糖尿病
  • 批准号:
    8269552
  • 财政年份:
    2010
  • 资助金额:
    $ 15.27万
  • 项目类别:
Periodontitis, Biomarkers and Cardiovascular Disease
牙周炎、生物标志物和心血管疾病
  • 批准号:
    7143643
  • 财政年份:
    2006
  • 资助金额:
    $ 15.27万
  • 项目类别:

相似海外基金

Enhancing gamete cryoprotective properties of graphene oxide by dual functionalization with antioxidants and non-penetrating cryoprotectant molecules
通过抗氧化剂和非渗透性冷冻保护剂分子的双重功能化增强氧化石墨烯的配子冷冻保护特性
  • 批准号:
    24K18002
  • 财政年份:
    2024
  • 资助金额:
    $ 15.27万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
SBIR Phase I: Sustainable antioxidants for industrial process fluids
SBIR 第一阶段:工业过程流体的可持续抗氧化剂
  • 批准号:
    2222215
  • 财政年份:
    2023
  • 资助金额:
    $ 15.27万
  • 项目类别:
    Standard Grant
Development of a new bone augmentation method that enables long-term survival and long-term functional expression of transplanted cells by antioxidants
开发一种新的骨增强方法,通过抗氧化剂使移植细胞能够长期存活和长期功能表达
  • 批准号:
    23K09272
  • 财政年份:
    2023
  • 资助金额:
    $ 15.27万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Non-Invasive Probing Cellular Oxidative Stress and Antioxidants Therapeutic Effectiveness
非侵入性探测细胞氧化应激和抗氧化剂的治疗效果
  • 批准号:
    10652764
  • 财政年份:
    2023
  • 资助金额:
    $ 15.27万
  • 项目类别:
Mitochondria-targeting Novel Cationic Hydrazone Antioxidants for the Treatment of Preeclampsia
线粒体靶向新型阳离子腙抗氧化剂用于治疗先兆子痫
  • 批准号:
    10730652
  • 财政年份:
    2023
  • 资助金额:
    $ 15.27万
  • 项目类别:
Latent Antioxidants for Environmentally Responsible Polymer Formulations
用于环保聚合物配方的潜在抗氧化剂
  • 批准号:
    RGPIN-2018-04107
  • 财政年份:
    2022
  • 资助金额:
    $ 15.27万
  • 项目类别:
    Discovery Grants Program - Individual
Contribution of antioxidants to regeneration of rotator cuff insertion
抗氧化剂对肩袖插入再生的贡献
  • 批准号:
    22K16720
  • 财政年份:
    2022
  • 资助金额:
    $ 15.27万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Effects of different doses of antioxidants(Vitamin E) intake on exercise induced oxidative stress, antioxidative capacity and chronic inflammation
不同剂量抗氧化剂(维生素E)摄入对运动引起的氧化应激、抗氧化能力和慢性炎症的影响
  • 批准号:
    22K11609
  • 财政年份:
    2022
  • 资助金额:
    $ 15.27万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Polyunsaturated fatty acid (PUFA), inflammation and antioxidants
多不饱和脂肪酸 (PUFA)、炎症和抗氧化剂
  • 批准号:
    RGPIN-2019-05674
  • 财政年份:
    2022
  • 资助金额:
    $ 15.27万
  • 项目类别:
    Discovery Grants Program - Individual
Suppressed methemoglobin formation of artificial red cell by liposomal antioxidants and its mechanism.
脂质体抗氧化剂抑制人工红细胞高铁血红蛋白形成及其机制
  • 批准号:
    22K12824
  • 财政年份:
    2022
  • 资助金额:
    $ 15.27万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了