Periodontitis, Biomarkers and Cardiovascular Disease

牙周炎、生物标志物和心血管疾病

• 批准号: 7143643
• 负责人: KAUMUDI J JOSHIPURA
• 金额: $ 65.2万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7143643
• 关键词: biomarker; blood; clinical research; health; inflammation; periodontitis; stroke

DESCRIPTION (provided by applicant): Our overall objective is to evaluate the association between chronic periodontal disease and incidence of cardiovascular disease, and to prospectively assess the role of inflammatory biomarkers in this association. Results from our epidemiologic studies among men show associations between periodontal disease and increased risk of (a) peripheral arterial disease (PAD) and (b) ischemic stroke. The proposed study will be conducted among male and female participants of two ongoing prospective studies: the Health Professionals' Follow-up Study, with over 50,000 men, and the Nurses' Health Study with over 100,000 women. Our prospective study in the same populations and several other studies are already supported to evaluate the association between periodontal disease, inflammatory markers and coronary heart disease. Hence we limit this application to evaluating the association between periodontal bone loss and ischemic stroke and PAD. We have demonstrated associations between periodontal disease and pro-inflammatory cytokines, markers of inflammation, and endothelial dysfunction in these cohorts. We will evaluate prospectively the relationship between standard measures of periodontal disease and incidence of PAD and ischemic stroke, and evaluate whether markers of inflammation and endothelial dysfunction may mediate the association between periodontal disease and ischemic stroke and PAD. This will be the first study to evaluate the relationship between periodontal disease and PAD among women, and among the first studies to prospectively evaluate inflammatory mediators in the pathway between periodontal disease and cardiovascular disease. We will include all incident cases and two matched controls per case, from the subgroup who already provided blood samples, and obtain their pre-existing radiographs from their dentists after requesting these participant's consent. The biochemical marker analyses will be conducted from the blood samples participants for whom we obtain dental radiographs. Ischemic stroke and PAD will be verified from medical records. We anticipate 500 eligible cases of ischemic stroke and 500 PAD cases and 2 matched controls per case, with a total sample size of 3,000. Since periodontal disease is very common, if it is found to increase the risk of CVD, millions of people may be impacted. The results from this study may suggest possibilities for prevention of CVD that would need to be further explored.

DESCRIPTION (provided by applicant): Our overall objective is to evaluate the association between chronic periodontal disease and incidence of cardiovascular disease, and to prospectively assess the role of inflammatory biomarkers in this association.我们对男性的流行病学研究结果显示，牙周病与 (a) 外周动脉疾病 (PAD) 和 (b) 缺血性中风的风险增加之间存在关联。拟议的研究将在两项正在进行的前瞻性研究的男性和女性参与者中进行：健康专业人员随访研究，有超过 50,000 名男性参与，护士健康研究有超过 100,000 名女性参与。我们在同一人群中进行的前瞻性研究和其他几项研究已经得到支持，以评估牙周病、炎症标志物和冠心病之间的关联。因此，我们将此应用限制为评估牙周骨丢失与缺血性中风和 PAD 之间的关联。我们已经在这些队列中证明了牙周病与促炎细胞因子、炎症标志物和内皮功能障碍之间的关联。我们将前瞻性评估牙周病标准测量与 PAD 和缺血性卒中发病率之间的关系，并评估炎症和内皮功能障碍标志物是否可能介导牙周病与缺血性卒中和 PAD 之间的关联。这将是第一项评估女性牙周病与 PAD 之间关系的研究，也是第一项前瞻性评估牙周病与心血管疾病之间通路中炎症介质的研究。我们将包括所有事件病例和每个病例的两个匹配对照，这些对照来自已提供血液样本的亚组，并在请求这些参与者同意后从牙医那里获取他们预先存在的射线照片。生化标志物分析将从我们获得牙科射线照片的参与者的血液样本中进行。缺血性中风和 PAD 将通过病历进行验证。我们预计将有 500 例符合条件的缺血性中风病例和 500 例 PAD 病例，每个病例有 2 个匹配的对照，总样本量为 3,000。由于牙周病非常常见，如果发现它会增加心血管疾病的风险，数百万人可能会受到影响。这项研究的结果可能表明预防心血管疾病的可能性需要进一步探索。