Midcareer Investigator Award

职业生涯中期研究员奖

• 批准号: 7213352
• 负责人: Clayton A. Wiley
• 金额: $ 13.47万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-15 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7213352
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DESCRIPTION (provided by applicant): The current proposal is a competitive renewal of a previously funded K24. The Principal Investigator, Dr. Clayton Wiley, is a clinical and experimental Neuropathologist with extensive experience in research of neurological disease and in mentorship of physician scientists. Dr. Wiley's research has focused on neurodegenerative diseases with particular emphasis on how the AIDS virus mediates neurological damage. He is an active investigator in 2 funded centers studying the neurodegenerative disorders of Alzheimer's Disease and Parkinson's Disease, a non-funded Center for AIDS Research and is currently a funded Principal Investigator of grants focused on HIV mediated damage of the brain. In the initial 5 years of this K24, Dr. Wiley transitioned his predominantly tissue based studies into a more clinical orientation examining the use of state of the art imaging technology to monitor immune cell interactions with the nervous system using human and non-human primates. The final 5 years of proposed K24 funding will be directed at completing these studies and broadening the approach to other neurodegenerative disorders (e.g. Alzheimer's Disease). Dr. Wiley is also an active mentor for physician scientists at all stages of training and has been a leading innovator in development of training programs. During the first 5 years of K24 support Dr. Wiley co-directed 2 T32 training programs, served on the executive committees of K30 and K12 programs and re-built and directed the Pittsburgh MSTP, taking a moribund program and creating a model training system for budding clinical investigators. Renewal of the K24 proposal will protect Dr. Wiley's time from classroom, clinical and administrative responsibilities allowing him to focus his efforts on developing his clinical research program. In addition to advancing his clinical and preclinical studies, Dr. Wiley will engage in a rigorous clinical scientist training didactic curriculum and participate in national and international workshops on imaging, modeling and statistical analyses.

描述（由申请人提供）：当前的提案是先前资助的K24的竞争续约。首席研究员克莱顿·威利（Clayton Wiley）博士是一名临床和实验性神经病理学家，在神经疾病研究和医师科学家的指导方面具有丰富的经验。 Wiley博士的研究集中在神经退行性疾病上，特别着重于艾滋病病毒如何介导神经系统损害。他是研究阿尔茨海默氏病和帕金森氏病的神经退行性疾病的两个资助中心的活跃研究者，这是一个未资助的艾滋病研究中心，目前是主要针对HIV介导的大脑损害的赠款的资助的首席研究员。在此K24的最初5年中，Wiley博士将其主要基于组织的研究转变为更临床的取向，研究了使用人类和非人类灵长类动物的神经成像技术的使用来监测与神经系统的免疫细胞相互作用。拟议的K24资金的最后5年将致力于完成这些研究，并扩大其他神经退行性疾病的方法（例如，阿尔茨海默氏病）。 Wiley博士还是培训的各个阶段的医师科学家的积极导师，并且一直是培训计划开发的领先创新者。在K24的前5年中，Wiley博士共同执导了2个T32培训计划，曾在K30和K12计划的执行委员会任职，并重新构建并指导匹兹堡MSTP，进行了垂死的计划，并创建了用于萌芽临床研究人员的模型培训系统。 K24提案的续签将保护Wiley博士的时间免受课堂，临床和行政责任，从而使他能够将精力集中在制定临床研究计划上。除了进步他的临床研究外，Wiley博士还将从事严格的临床科学家培训教学课程，并参加有关成像，建模和统计分析的国家和国际研讨会。