ReLiSyR-Mental Health: Repurposing Living Systematic Reviews to inform drug selection for clinical trials in mental health

ReLiSyR-心理健康：重新利用生命系统评价为心理健康临床试验的药物选择提供信息

• 批准号: 2888455
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2888455
• 关键词: ReLiSyR; Mental; Health; Repurposing; Living

My PhD will develop a Repurposing Living Systematic Review which will curate and analyse evidence streams relevant to clinical trials in mental health. In addition to considering single drug interventions, ReLiSyR-Mental Health will consider combination drug interventions, non-pharmacological treatments, and combinations of treatment modalities. I will use triangulation approaches to integrate information preclinical data, clinical data and large-scale human genetics research. Further, I will develop Bayesian ranking approaches to prioritising interventions for subsequent research. In the initial phase, I will develop Systematic Online Living Evidence Summaries (SOLES) for preclinical and clinical in vivo research related to psychosis, depression, and anxiety, intending to utilise these platforms in ReLiSyR-Mental Health's development. Systematic Online Living Evidence Summaries (SOLES) are interactive platforms which seek to provide a comprehensive overview of the literature relevant to a given area of research. SOLES use supervised NLP screening algorithms to identify publications relevant to a given research area of interest. This methodology seeks to optimise specificity of the SOLES platform whilst maintaining efficiency of their development workflow. A distinguishing feature of SOLES platforms is that they hold a corpus of studies that has already been through an initial automated screening process. By automating full-text retrieval and employing text-mining approaches, PICO elements not included within the Title and Abstract (TiAb) text of a research article can be extracted from the full-text, allowing for a more granular characterisation of the available literature than typically possible in biomedical libraries.Constraints on time and researcher availability often impede comprehensive evidence synthesis, with dual-screening of papers for inclusion being particularly resource intensive. Further, the challenge of including all pertinent PICO (Patient, Intervention, Comparison, Outcome) elements within the word count limitations of Title and Abstract (TiAb) text in primary research articles means that standard literature searches often fail to capture all of the relevant research. Conducting a literature search within the relevant SOLES platform, as opposed to a biomedical library, may reduce the retrieval of irrelevant citations whilst enhancing the search's sensitivity. This may optimise the efficiency and completeness of study selection for systematic reviews, and thus enhance the depth and quality of the evidence synthesis. A secondary PhD aim will be to validate the methodology of this study selection approach.

我的博士学位将制定一项重新利用生活系统审查，该审查将策划和分析与心理健康临床试验相关的证据流。除了考虑单一药物干预外，ReLiSyR-Mental Health 还将考虑联合药物干预、非药物治疗以及治疗方式的组合。我将使用三角测量方法来整合临床前数据、临床数据和大规模人类遗传学研究的信息。此外，我将开发贝叶斯排名方法来优先考虑后续研究的干预措施。在初始阶段，我将开发系统在线生活证据摘要（SOLES），用于与精神病、抑郁和焦虑相关的临床前和临床体内研究，打算在 ReLiSyR-Mental Health 的开发中利用这些平台。系统在线生活证据摘要 (SOLES) 是交互式平台，旨在提供与特定研究领域相关的文献的全面概述。 SOLES 使用受监督的 NLP 筛选算法来识别与特定感兴趣的研究领域相关的出版物。该方法旨在优化 SOLES 平台的特异性，同时保持开发工作流程的效率。 SOLES 平台的一个显着特征是它们拥有已经通过初始自动筛选过程的研究语料库。通过自动化全文检索和采用文本挖掘方法，可以从全文中提取研究文章的标题和摘要 (TiAb) 文本中未包含的 PICO 元素，从而比生物医学图书馆中通常可能的方式更详细地描述可用文献。时间和研究人员可用性的限制通常会阻碍全面的证据合成，对论文进行双重筛选以纳入尤其是资源 密集的。此外，将所有相关 PICO（患者、干预、比较、结果）元素纳入主要研究文章标题和摘要 (TiAb) 文本字数限制的挑战意味着标准文献检索通常无法捕获所有相关研究。与生物医学图书馆相比，在相关 SOLES 平台内进行文献检索可能会减少不相关引文的检索，同时提高检索的敏感性。这可以优化系统评价研究选择的效率和完整性，从而提高证据合成的深度和质量。博士学位的第二个目标是验证本研究选择方法的方法。