Aluminium Metal-Organic Frameworks as Vaccine Adjuvants

铝金属有机框架作为疫苗佐剂

• 批准号: 2888583
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2888583
• 关键词: Aluminium; Metal; Organic; Frameworks; Vaccine

Typically, aluminium hydroxide particles are used as vaccine adjuvants, to stimulate the immune system when the vaccine is delivered and so increase therapeutic effect. This project will use aluminium metal-organic frameworks (MOFs) as alternative adjuvants in collaboration with Prof Jim Brewer, focussing on the development of novel synthetic methodology to control particle size and produce surface-modified, aluminium MOF nanoparticles.

通常，氢氧化铝颗粒用作疫苗佐剂，在疫苗递送时刺激免疫系统，从而提高治疗效果。该项目将与 Jim Brewer 教授合作，使用铝金属有机框架（MOF）作为替代佐剂，重点开发新型合成方法来控制粒径并生产表面改性的铝 MOF 纳米颗粒。