Brain Research/Acute Interventions: Neurological Emergencies Treatment Trials

描述（由申请人提供）：本提案是对神经急症治疗试验申请请求的回应。本摘要总结了俄勒冈健康与科学大学（OHSU） BRAINETT网络实现RFA具体目标的能力：-开发一个基础设施，以开展与急诊内科医生和神经临床医生的临床实践相关的神经急诊临床试验：BRAINETT代表了急诊医生、儿科医生、神经科医生、神经外科医生、创伤外科医生和神经强化医生的联盟。通过避免为每个单独的研究项目重新创建临床试验基础设施，提高神经急症临床研究的效率：BRAINETT建立在现有研究基础设施的基础上，该基础设施已支持10家医院15年的急性中风临床试验和15年的急诊医学研究，包括参与在院外环境中进行的3个最大的临床试验。-通过涉及数十个急诊科来加快招聘：BRAINETT最初将涉及4个急诊科，合并每年216,000人次的人口普查，以及两个大而多样化的县的EMS系统。-让广泛的调查人员参与，包括小型医院和非城市环境中的调查人员：BRAINETT调查人员与俄勒冈州的大小、城市和农村医院有着广泛的临床和研究联系，并可根据需要扩大网络。-招募广泛的参与者，特别是少数民族：BRAINETT研究地点反映了他们所服务的社区的患者范围，如申请中详细说明的那样。-促进将研究成果转化为临床实践，特别是社区医院环境，并得到急诊医生的普遍认可：OHSU作为俄勒冈州唯一的学术医疗中心，使其成为急诊医学和其他专业的影响力领导者。-促进开发和测试创新的远程医疗方法，使急诊部门的非现场专家参与治疗神经系统疾病：OHSU在俄勒冈州农村和其他偏远社区使用远程医疗方面有着良好的记录。BRAINETT团队拥有经验和资源，可以作为这一重要倡议的关键参与者。

DESCRIPTION (provided by applicant): This proposal is in response to a Request for Applications for the Neurological Emergencies Treatment Trials. This abstract summarizes the capability of the Oregon Health & Science University (OHSU) BRAINETT network to accomplish the specific aims of the RFA: - To develop an infrastructure to carry out clinical trials in neurological emergencies that are relevant to the clinical practice of both emergency medicine physicians and neuro-clinicians: BRAINETT represents a coalition of emergency physicians, pediatricians, neurologists, neurosurgeons, trauma surgeons, and neuro- Intensivists. To enhance the efficient conduct of clinical research in neurological emergencies by avoiding de novo creation of clinical trial infrastructure for each individual research project: BRAINETT builds on an existing research infrastructure that has supported 15 years of clinical trials of acute stroke at 10 hospitals and 15 years of Emergency Medicine research including participation in the 3 largest clinical trials ever conducted in the out-of-hospital setting. - To expedite recruitment by involving scores of emergency departments: BRAINETT will initially involve 4 EDs with a combined annual census of 216,000 visits, along with the EMS systems of 2 large and diverse counties. - To involve a wide spectrum of investigators, including those at smaller hospitals and in non-urban settings: The BRAINETT investigators have extensive clinical and research ties with Oregon hospitals, large and small, urban and rural, and can expand the network as needed. - To recruit a broad range of participants, particularly minorities: BRAINETT study sites reflect the range of patients seen in the communities they serve, as detailed in the application. - To facilitate the transfer of research results to clinical practice, especially to community hospital settings, and the general endorsement by emergency medicine physicians: OHSU's role as the only academic medical center in Oregon makes it an influence leader for Emergency Medicine and other specialties. - To foster the development and testing of innovative telemedicine methods to involve off-site specialists in the care of neurological disorders in emergency departments: OHSU has a strong track record of using telemedicine in rural Oregon and other remote communities. The BRAINETT team has the experience and resources to serve as a key participant in this important initiative.