Brain Research/Acute Interventions: Neurological Emergencies Treatment Trials

大脑研究/急性干预：神经紧急情况治疗试验

• 批准号: 7924228
• 负责人: ROBERT A. LOWE
• 金额: $ 19.41万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7924228
• 关键词: Academic Medical Centers; Accident and Emergency department; Acute; Address; Caring; Censuses; Childhood; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Hospitals; County; Data; Development; Emergency Medicine; Emergency Situation; Emergency medical service; Emergency treatment; Fostering; Funding; Health; Health Sciences; Health Services Research; Heart Arrest; Hospitals; Individual; Informed Consent; Institutes; Intervention; Medical; Methods; Minority; Molds; Nervous System Trauma; Neurological emergencies; Neurologist; Neurology; Neurosurgeon; Operative Surgical Procedures; Oregon; Participant; Patients; Pediatrics; Physicians; Productivity; Recording of previous events; Recruitment Activity; Request for Applications; Research; Research Ethics Committees; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resources; Role; Rural; Site; Specialist; Spinal cord injury; Stroke; System; Telemedicine; Testing; Trauma; Traumatic Brain Injury; United States National Institutes of Health; Universities; Visit; Work; abstracting; acute stroke; brain research; clinical practice; design; experience; injured; innovation; medical specialties; member; nervous system disorder; neurosurgery; pediatrician; response; systems research; treatment trial

DESCRIPTION (provided by applicant): This proposal is in response to a Request for Applications for the Neurological Emergencies Treatment Trials. This abstract summarizes the capability of the Oregon Health & Science University (OHSU) BRAINETT network to accomplish the specific aims of the RFA: - To develop an infrastructure to carry out clinical trials in neurological emergencies that are relevant to the clinical practice of both emergency medicine physicians and neuro-clinicians: BRAINETT represents a coalition of emergency physicians, pediatricians, neurologists, neurosurgeons, trauma surgeons, and neuro- Intensivists. To enhance the efficient conduct of clinical research in neurological emergencies by avoiding de novo creation of clinical trial infrastructure for each individual research project: BRAINETT builds on an existing research infrastructure that has supported 15 years of clinical trials of acute stroke at 10 hospitals and 15 years of Emergency Medicine research including participation in the 3 largest clinical trials ever conducted in the out-of-hospital setting. - To expedite recruitment by involving scores of emergency departments: BRAINETT will initially involve 4 EDs with a combined annual census of 216,000 visits, along with the EMS systems of 2 large and diverse counties. - To involve a wide spectrum of investigators, including those at smaller hospitals and in non-urban settings: The BRAINETT investigators have extensive clinical and research ties with Oregon hospitals, large and small, urban and rural, and can expand the network as needed. - To recruit a broad range of participants, particularly minorities: BRAINETT study sites reflect the range of patients seen in the communities they serve, as detailed in the application. - To facilitate the transfer of research results to clinical practice, especially to community hospital settings, and the general endorsement by emergency medicine physicians: OHSU's role as the only academic medical center in Oregon makes it an influence leader for Emergency Medicine and other specialties. - To foster the development and testing of innovative telemedicine methods to involve off-site specialists in the care of neurological disorders in emergency departments: OHSU has a strong track record of using telemedicine in rural Oregon and other remote communities. The BRAINETT team has the experience and resources to serve as a key participant in this important initiative.

描述(由申请人提供)：本提案是对神经急症治疗试验申请的回应。这篇摘要总结了俄勒冈健康与科学大学(OHSU)BRAINETT网络实现RFA具体目标的能力：-开发基础设施，在与急诊医生和神经临床医生的临床实践相关的神经紧急情况下进行临床试验：BRAINETT代表急诊医生、儿科医生、神经学家、神经外科医生、创伤外科医生和神经强化医生的联盟。为了通过避免为每个研究项目从头创建临床试验基础设施来提高神经急诊临床研究的效率：BRAINETT建立在现有研究基础设施的基础上，该基础设施支持了10家医院15年的急性中风临床试验和15年的急诊医学研究，包括参与了有史以来在医院外进行的3项最大的临床试验。-通过涉及数十个急救部门加快招聘：BRAINETT最初将涉及4名急救人员，年人口普查合计21.6万人次，以及2个大而不同的县的EMS系统。-让广泛的调查人员参与进来，包括那些在较小医院和非城市环境中的调查人员：BRAINETT调查人员与俄勒冈州的大小、城市和农村医院有着广泛的临床和研究联系，并可以根据需要扩大网络。-招募广泛的参与者，特别是少数族裔：BRAINETT研究网站反映了他们所服务的社区中看到的患者范围，申请中详细说明了这一点。-促进将研究成果转化为临床实践，特别是社区医院环境，以及急诊医学医生的普遍认可：俄勒冈州卫生与公众服务部作为俄勒冈州唯一的学术医学中心，使其成为急诊医学和其他专业的有影响力的领导者。-促进开发和测试创新的远程医疗方法，使非现场专家参与急诊科神经疾病的护理：OHSU在俄勒冈州农村和其他偏远社区使用远程医疗方面有着良好的记录。BRAINETT团队拥有作为这一重要倡议的关键参与者的经验和资源。