Brain Research/Acute Interventions: Neurological Emergencies Treatment Trials

大脑研究/急性干预：神经紧急情况治疗试验

• 批准号: 7676774
• 负责人: ROBERT A. LOWE
• 金额: $ 19.41万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676774
• 关键词: Academic Medical Centers; Accident and Emergency department; Acute; Address; Caring; Censuses; Childhood; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Community Hospitals; County; Data; Development; Emergency Medicine; Emergency Situation; Emergency medical service; Emergency treatment; Fostering; Funding; Health; Health Sciences; Health Services Research; Heart Arrest; Hospitals; Individual; Informed Consent; Institutes; Intervention; Medical; Methods; Minority; Molds; Nervous System Trauma; Neurological emergencies; Neurologist; Neurology; Neurosurgeon; Operative Surgical Procedures; Oregon; Participant; Patients; Pediatrics; Physicians; Productivity; Recording of previous events; Recruitment Activity; Request for Applications; Research; Research Ethics Committees; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resources; Role; Rural; Site; Specialist; Spinal cord injury; Stroke; System; Telemedicine; Testing; Trauma; Traumatic Brain Injury; United States National Institutes of Health; Universities; Visit; Work; abstracting; acute stroke; brain research; clinical practice; design; experience; injured; innovation; medical specialties; member; nervous system disorder; neurosurgery; pediatrician; response; systems research; treatment trial

DESCRIPTION (provided by applicant): This proposal is in response to a Request for Applications for the Neurological Emergencies Treatment Trials. This abstract summarizes the capability of the Oregon Health & Science University (OHSU) BRAINETT network to accomplish the specific aims of the RFA: - To develop an infrastructure to carry out clinical trials in neurological emergencies that are relevant to the clinical practice of both emergency medicine physicians and neuro-clinicians: BRAINETT represents a coalition of emergency physicians, pediatricians, neurologists, neurosurgeons, trauma surgeons, and neuro- Intensivists. To enhance the efficient conduct of clinical research in neurological emergencies by avoiding de novo creation of clinical trial infrastructure for each individual research project: BRAINETT builds on an existing research infrastructure that has supported 15 years of clinical trials of acute stroke at 10 hospitals and 15 years of Emergency Medicine research including participation in the 3 largest clinical trials ever conducted in the out-of-hospital setting. - To expedite recruitment by involving scores of emergency departments: BRAINETT will initially involve 4 EDs with a combined annual census of 216,000 visits, along with the EMS systems of 2 large and diverse counties. - To involve a wide spectrum of investigators, including those at smaller hospitals and in non-urban settings: The BRAINETT investigators have extensive clinical and research ties with Oregon hospitals, large and small, urban and rural, and can expand the network as needed. - To recruit a broad range of participants, particularly minorities: BRAINETT study sites reflect the range of patients seen in the communities they serve, as detailed in the application. - To facilitate the transfer of research results to clinical practice, especially to community hospital settings, and the general endorsement by emergency medicine physicians: OHSU's role as the only academic medical center in Oregon makes it an influence leader for Emergency Medicine and other specialties. - To foster the development and testing of innovative telemedicine methods to involve off-site specialists in the care of neurological disorders in emergency departments: OHSU has a strong track record of using telemedicine in rural Oregon and other remote communities. The BRAINETT team has the experience and resources to serve as a key participant in this important initiative.

描述（由申请人提供）：本提案是对神经急症治疗试验申请请求的回应。本摘要总结了俄勒冈健康与科学大学 (OHSU) BRAINETT 网络实现 RFA 特定目标的能力： - 开发基础设施，以在与急诊医学医师和神经临床医生的临床实践相关的神经系统紧急情况下进行临床试验：BRAINETT 代表急诊医师、儿科医生、神经科医生、神经外科医生的联盟， 创伤外科医生和神经重症科医生。 为了通过避免为每个单独的研究项目从头创建临床试验基础设施来提高神经紧急情况临床研究的效率：BRAINETT 以现有的研究基础设施为基础，该基础设施已支持在 10 家医院进行了 15 年的急性中风临床试验和 15 年的急诊医学研究，包括参与有史以来在院外环境中进行的 3 项最大的临床试验。 - 为了通过数十个急诊部门的参与来加快招募速度：BRAINETT 最初将涉及 4 个急诊科，每年的人口普查总人数为 216,000 人次，以及 2 个大型且多样化县的 EMS 系统。 - 吸引广泛的研究人员，包括小型医院和非城市环境的研究人员：BRAINETT 的研究人员与俄勒冈州大大小小的、城市和农村的医院有着广泛的临床和研究联系，并且可以根据需要扩大网络。 - 招募广泛的参与者，特别是少数群体：BRAINETT 研究地点反映了他们所服务的社区中所见的患者范围，如申请中详细说明的那样。 - 促进研究成果转化为临床实践，特别是社区医院环境，并得到急诊医学医师的普遍认可：OHSU 作为俄勒冈州唯一的学术医疗中心，使其成为急诊医学和其他专业领域的影响力领导者。 - 促进创新远程医疗方法的开发和测试，让异地专家参与急诊科神经系统疾病的护理：OHSU 在俄勒冈州农村和其他偏远社区使用远程医疗方面拥有良好的记录。 BRAINETT 团队拥有丰富的经验和资源，可以作为这一重要举措的主要参与者。