Western New England Maternal Pediatric Adolescent AIDS Clinical Trials Unit

描述(由申请人提供)：本申请资助“新英格兰西部母婴青少年艾滋病临床试验中心(WNE-MPAACTU)”，是对RFA-AI-05-002的回应。WNE-MPAACTU是一个临床站点联盟，由马萨诸塞州伍斯特的马萨诸塞大学医学院的一个主要单位、马萨诸塞州斯普林菲尔德的贝州医学中心和康涅狄格州哈特福德的康涅狄格州儿童医学中心的临床试验站点组成。该联盟的研究人员自1990年以来一直合作确定母婴传播艾滋病毒-1(MTCT)和儿童艾滋病毒-1感染的发病机制，并在基于发病机制的临床试验的设计和实施方面经验丰富。WNE-MPAACTU的目标是：1)提高我们对母婴传播和儿童HIV-1感染的发病机制的了解；2)改进儿童和青少年HIV-1感染的预防策略，包括开发有效的预防性疫苗；以及3)改进儿童和青少年HIV-1感染的治疗策略，包括管理共病和ART毒性。这些目标与国际母儿青少年临床试验(IMPAACT)网络的目标最为一致，该网络将进行疫苗、转译研究/药物开发、临床护理优化和MFCT研究预防。根据过去的业绩和预测的应计项目，西北太平洋区域中心已被选为亚太区域技术中心“高度优先的核心地点”。该中心的调查人员在IMPAACT的发展中发挥了领导作用，并将通过领导、培训和指导以及方案设计、实施和积累，继续为IMPAACT的科学议程作出贡献。 管理组件：

DESCRIPTION (provided by applicant): This proposal to fund the "Western New England Maternal Pediatric Adolescent AIDS Clinical Trials Unit (WNE-MPAACTU)" is submitted in response to RFA-AI-05-002. The WNE-MPAACTU is a consortium of clinical sites consisting of a main unit at the University of Massachusetts Medical School in Worcester, MA, and Clinical Trials Sites at Baystate Medical Center in Springfield, MA and Connecticut Children's Medical Center in Hartford, CT. Consortium investigators have worked together since 1990 to define the pathogenesis of mother-to-child HIV-1 transmission (MTCT) and pediatric HIV-1 infection and are highly experienced in the design and implementation of pathogenesis-based clinical trials. WNE-MPAACTU goals are: 1) To improve our understanding of the pathogenesis of MTCT and pediatric HIV-1 infection; 2) To improve prevention strategies for pediatric and adolescent HIV-1 infection, including the development of an effective preventive vaccine; and 3) To improve treatment strategies for pediatric and adolescent HIV-1 infection, including the management of co-morbidities and ART toxicities. These goals are most aligned with the goals of the International Maternal Pediatric Adolescent Clinical Trials (IMPAACT) network, which will conduct Vaccine, Translational Research/Drug Development, Optimization of Clinical Care, and Prevention of MFCT studies. Based on past performance and projected accruals, WNE-PACTU has been selected as an IMPAACT "highly-preferred core site". WNE-MPAACTU investigators have played leadership roles in IMPAACT's development and will continue to contribute to the IMPAACT scientific agenda through leadership, training and mentorship, and protocol design, implementation, and accrual. ADMINISTRATIVE COMPONENT: