University of Massachusetts Center for Clinical and Translational Science

联系PD/PI：Luzuriaga，Katherine 项目摘要/摘要--O。总体 UMCCTS于2006年组织，NIH于2010年资助(2015年续期)，其目标是改善 通过推进翻译科学，通过催化高质量的研究，提供健康和医疗保健 通过建立和支持一支强大的翻译队伍，跨越翻译领域。我们的 总体目标是加快新产品和方法的开发，以促进患者护理和 社区卫生。作为马萨诸塞州唯一的公立大学系统(UMassus)与该州的两个 安全网临床系统(华盛顿大学纪念医疗保健，UMMHC；贝州健康)，我们共享一个持久的 注重公众参与和社会效益。UMCCTS吸引了广泛的利益相关者 (社区、患者团体、基金会、行业、NCATS和CTSA中心)，以确保我们的研究 我们培训的支持和劳动力解决了对我们所服务的社区重要的问题。与我们的合作伙伴， 我们确定重要的问题和需求，开发和验证支持平台，提供 促进跨学科团队科学，教育下一代研究人员。我们使用数据和 分析以生成知识，应用这些知识来提高性能，然后使用学到的经验教训 告知并改进下一个改进周期。UMCCTS劳动力发展计划确保未来 临床和转化性研究(CTR)企业的可持续性。 我们的5个具体目标与NCATS FOA中陈述的5个NCATS战略目标相对应，并建立在我们 以前的成功：目标1：劳动力发展：建立和支持一支跨学科的CTR员工队伍 促进高影响力翻译研究的知识、技能和机构环境；目标2： 协作/参与：在整个翻译过程中让利益相关者参与进来，以优化证据- 以社区为基础的综合研究实践，并将这些实践应用于改善 个人和人口健康；目标3：终身融合--任职人数不足或处境不利 人口：改进洞察力和做法，确保将发现转化为所有可能受益的人； 目标4：方法和流程：开发、测试和共享针对翻译中的关键差距的创新解决方案 从发现到社区的研究过程；目标5：信息学：开发、示范和传播 加快翻译科学和翻译研究运营的信息学创新，以及 这为学习卫生系统提供了必要的证据基础。 缩写：CECC-社区参与和协作核心；CRPG-临床研究 专业小组；D3Health-医疗保健数据驱动发现中心；PEPP-准备 专业实践工程师；SPRC-科学参与研究中心；TRACS-翻译 研究加速器；UMA-UMASS AMHERST；UMB-UMASS波士顿；UMD-UMASS达特茅斯；UML- UMMS-UMassal医学院 第185页 项目摘要/摘要 联系PD/PI：Luzuriaga，Katherine

Contact PD/PI: Luzuriaga, Katherine PROJECT SUMMARY/ABSTRACT – O. OVERALL The UMCCTS was organized in 2006 and NIH-funded in 2010 (renewed 2015), with the vision of improving health and health care delivery by advancing the science of translation, by catalyzing high-quality research across the translational spectrum, and by building and supporting a robust translational workforce. Our overarching goal is to speed the development of new products and approaches to advance patient care and community health. As Massachusetts’ only public university system (UMass) partnered with 2 of the state’s safety net clinical systems (UMass Memorial Health Care, UMMHC; Baystate Health), we share an enduring focus on public engagement and societal benefit. The UMCCTS engages a broad range of stakeholders (communities, patient groups, foundations, industry, NCATS and CTSA hubs) to ensure that the research we support and workforce we train address problems important to the communities we serve. With our partners, we identify important problems and needs, develop and validate enabling platforms, provide resources that facilitate transdisciplinary team science, and educate the next generation of investigators. We use data and analytics to generate knowledge, apply that knowledge to improve performance, then use lessons learned to inform and refine the next improvement cycle. UMCCTS Workforce Development programs ensure the future sustainability of the clinical and translational research (CTR) enterprise. Our 5 Specific Aims correspond to the 5 NCATS strategic goals stated in the NCATS FOA and build on our prior successes: Aim 1: Workforce Development: Build and support a transdisciplinary CTR workforce with the knowledge, skills, and institutional environment to advance high-impact translational research; Aim 2: Collaboration/Engagement: Engage stakeholders throughout the translational process to optimize evidence- based, community-integrated research practices and apply these practices to specific projects that improve individual and population health; Aim 3: Integration Across the Lifespan & Underrepresented or Disadvantaged Populations: Improve insights and practices that ensure that discoveries are translated to all who might benefit; Aim 4: Methods & Processes: Develop, test, and share innovative solutions to critical gaps in the translational research process from discovery to community; Aim 5: Informatics: Develop, demonstrate, and disseminate informatics innovations that accelerate both translational science and translational research operations and that provide the essential evidence base for learning health systems. Abbreviations: CECC - Community Engagement and Collaboration Core; CRPG - Clinical Research Professionals Group; D3Health - Center for Data-Driven Discovery in Health Care; PEPP - Preparing Engineers for Professional Practice; SPRC - Science Participation Research Center; TRAcs - Translational Research Accelerator; UMA - UMass Amherst; UMB - UMass Boston; UMD - UMass Dartmouth; UML - UMass Lowell; UMMHC - UMass Memorial Healthcare; UMMS - UMass Medical School Page 185 Project Summary/Abstract Contact PD/PI: Luzuriaga, Katherine