University of Massachusetts Center for Clinical and Translational Science

联系PD/PI：Luzuriaga，凯瑟琳 项目概要/摘要- O.整体 UMCCTS于2006年组织，2010年由NIH资助（2015年更新），其愿景是改善 通过促进翻译科学，通过催化高质量的研究， 跨翻译范围，并通过建立和支持强大的翻译工作队伍。我们 总体目标是加快新产品和方法的开发，以促进患者护理， 社区健康。作为马萨诸塞州唯一的公立大学系统（马萨诸塞大学）与该州的2个合作伙伴， 安全网临床系统（马萨诸塞大学纪念医疗保健，UMMHC; Baystate健康），我们分享一个持久的 注重公众参与和社会效益。UMCCTS吸引了广泛的利益相关者 （社区，患者团体，基金会，行业，NCATS和CTSA中心），以确保我们的研究， 我们培训的支持和劳动力解决了我们所服务的社区的重要问题。与我们的合作伙伴， 我们确定重要的问题和需求，开发和验证支持平台，提供资源， 促进跨学科团队科学，并教育下一代研究人员。我们使用数据和 分析以生成知识，应用这些知识来提高绩效，然后利用学到的经验教训， 通知并完善下一个改进周期。UMCCTS劳动力发展计划确保未来 临床和转化研究（CTR）企业的可持续性。 我们的5个具体目标对应于NCATS FOA中规定的5个NCATS战略目标，并建立在我们的 先前的成功：目标1：员工队伍发展：建立和支持跨学科CTR员工队伍， 知识，技能和制度环境，以促进高影响力的转化研究;目标2： 协作/参与：在整个翻译过程中让利益相关者参与进来，以优化证据- 基于社区的研究实践，并将这些实践应用于具体项目， 个人和人口健康;目标3：终生一体化和代表性不足或缺乏 人口：改进见解和做法，确保将发现转化为所有可能受益的人; 目标4：方法和流程：开发、测试和分享创新解决方案，以弥补翻译过程中的关键差距。 从发现到社区的研究过程;目标5：信息学：开发、演示和传播 信息学创新，加速了转化科学和转化研究业务， 这为学习卫生系统提供了必要的证据基础。 缩略语：CECC -社区参与和协作核心; CRPG -临床研究 专业人员组; D3 Health-医疗保健数据驱动发现中心; PEPP -准备 专业实践工程师; SPRC -科学参与研究中心; TRAC-翻译 研究加速器; UMA -马萨诸塞大学阿默斯特分校; UMB -马萨诸塞大学波士顿分校; UMD -马萨诸塞大学达特茅斯分校; UML -马萨诸塞大学 马萨诸塞大学洛厄尔分校; UMMHC -马萨诸塞大学纪念医疗保健; UMMS -马萨诸塞大学医学院 第185页 项目概要/摘要 联系PD/PI：Luzuriaga，凯瑟琳

Contact PD/PI: Luzuriaga, Katherine PROJECT SUMMARY/ABSTRACT – O. OVERALL The UMCCTS was organized in 2006 and NIH-funded in 2010 (renewed 2015), with the vision of improving health and health care delivery by advancing the science of translation, by catalyzing high-quality research across the translational spectrum, and by building and supporting a robust translational workforce. Our overarching goal is to speed the development of new products and approaches to advance patient care and community health. As Massachusetts’ only public university system (UMass) partnered with 2 of the state’s safety net clinical systems (UMass Memorial Health Care, UMMHC; Baystate Health), we share an enduring focus on public engagement and societal benefit. The UMCCTS engages a broad range of stakeholders (communities, patient groups, foundations, industry, NCATS and CTSA hubs) to ensure that the research we support and workforce we train address problems important to the communities we serve. With our partners, we identify important problems and needs, develop and validate enabling platforms, provide resources that facilitate transdisciplinary team science, and educate the next generation of investigators. We use data and analytics to generate knowledge, apply that knowledge to improve performance, then use lessons learned to inform and refine the next improvement cycle. UMCCTS Workforce Development programs ensure the future sustainability of the clinical and translational research (CTR) enterprise. Our 5 Specific Aims correspond to the 5 NCATS strategic goals stated in the NCATS FOA and build on our prior successes: Aim 1: Workforce Development: Build and support a transdisciplinary CTR workforce with the knowledge, skills, and institutional environment to advance high-impact translational research; Aim 2: Collaboration/Engagement: Engage stakeholders throughout the translational process to optimize evidence- based, community-integrated research practices and apply these practices to specific projects that improve individual and population health; Aim 3: Integration Across the Lifespan & Underrepresented or Disadvantaged Populations: Improve insights and practices that ensure that discoveries are translated to all who might benefit; Aim 4: Methods & Processes: Develop, test, and share innovative solutions to critical gaps in the translational research process from discovery to community; Aim 5: Informatics: Develop, demonstrate, and disseminate informatics innovations that accelerate both translational science and translational research operations and that provide the essential evidence base for learning health systems. Abbreviations: CECC - Community Engagement and Collaboration Core; CRPG - Clinical Research Professionals Group; D3Health - Center for Data-Driven Discovery in Health Care; PEPP - Preparing Engineers for Professional Practice; SPRC - Science Participation Research Center; TRAcs - Translational Research Accelerator; UMA - UMass Amherst; UMB - UMass Boston; UMD - UMass Dartmouth; UML - UMass Lowell; UMMHC - UMass Memorial Healthcare; UMMS - UMass Medical School Page 185 Project Summary/Abstract Contact PD/PI: Luzuriaga, Katherine