FASEB Conference: Renal Hemodynamics: Biomolecular Control Mechanisms Integrating

FASEB 会议：肾血流动力学：生物分子控制机制整合

• 批准号: 7329023
• 负责人: WILLIAM J ARENDSHORST
• 金额: $ 1.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7329023
• 关键词: Academy; Area; Armin; Australia; Award; Berlin; Biomedical Research; Blood Vessels; Carbon Monoxide; Cities; Clinical; Committee Members; Denmark; Depth; Diabetes Mellitus; Disease; Eicosanoids; Endothelin; Excretory function; Faculty; Feedback; Fostering; Genetic; Germany; Goals; Hand; Homeostasis; Human Resources; Hypertension; Injury; Iowa; Japan; Juxtaglomerular Apparatus; Kidney; Kidney Diseases; Metabolic syndrome; Molecular; Natriuresis; Nitric Oxide; Norway; Operative Surgical Procedures; Oxidative Stress; Paris, France; Patients; Physiological; Principal Investigator; Reactive Oxygen Species; Recommendation; Regulation; Renal Circulation; Renal Hypertension; Renin-Angiotensin System; Research; Research Personnel; Rivers; Schedule; Scientist; Signal Pathway; Signal Transduction; Sodium; Students; Sweden; Sympathetic Nervous System; Time; Translating; Travel; Tubular formation; Underrepresented Minority; Vascular resistance; Vermont; Woman; authority; experience; hemodynamics; kidney vascular structure; member; multidisciplinary; performance site; planetary Atmosphere; posters; pressure; programs; symposium

DESCRIPTION (provided by applicant): The FASEB Summer Research Conference on "Renal Hemodynamics: Biomolecular Control Mechanisms Integrating Vascular and Tubular Function" is scheduled for July 7-12, 2007 at Vermont Academy, Saxtons River, VT. The overall goal of this informal meeting is to provide a forum for multidisciplinary scientists to meet and openly discuss their most current research in a casual, relaxed atmosphere. There is ample time for poster sessions which fosters in-depth discussions, with special featured poster "hot-topic" sessions highlighting the latest ongoing research of students, fellows and young investigators. Conference aims are: 1) to convene an internationally recognized multidisciplinary group of investigators to discuss current research findings in the area of microcirculatory biomolecular control mechanisms that integrate vascular and tubular function in the kidney, 2) to promote the participation of young scientists with special emphasis on women and under-represented minorities, through recruitment and a travel award program; and 3) to translate basic biomedical research in renal hemodynamic and tubular function to major patient diseases that include renal disease, diabetes, and hypertension. Specific topics to be covered include: genetic regulation of the renin-angiotensin system and signaling pathways in the juxtaglomerular apparatus, intrinsic autoregulatory mechanisms: myogenic signaling and tubuloglomerular feedback, dynamic autoregulation and modulation of mechanisms, regulation of the renal circulation and tubular transport by carbon monoxide / nitric oxide, the sympathetic nervous system, eicosanoids, endothelin and oxidative stress / reactive oxygen species, pressure natriuresis: physiological / pathophysiological importance and molecular mechanisms integrating effects of arterial pressure on tubular function and sodium excretion, abnormalities in the regulation of renal vascular resistance in hypertension, diabetes mellitus, and the metabolic syndrome, genetic influences in diabetes and hypertension, and mechanisms of renal injury.

描述(由申请人提供)： FASE B夏季研究会议“肾脏血流动力学：整合血管和肾小管功能的生物分子控制机制”定于2007年7月7日至12日在佛蒙特州萨克斯顿河的佛蒙特学院举行。这次非正式会议的总体目标是为多学科科学家提供一个论坛，让他们在随意、轻松的气氛中会面并公开讨论他们最新的研究。有充足的时间进行海报会议，以促进深入讨论，特别是特别的海报“热门话题”会议突出了学生、研究员和年轻研究人员正在进行的最新研究。 会议的目的是：1)召集国际公认的多学科研究人员小组，讨论在微循环生物分子控制机制领域的最新研究成果，这些机制整合了肾脏的血管和肾小管功能；2)通过招募和旅行奖励计划，促进年轻科学家的参与，特别是女性和代表不足的少数族裔；以及3)将肾脏血流动力学和肾小管功能的基础生物医学研究转化为主要患者疾病，包括肾脏疾病、糖尿病和高血压。 具体主题包括：肾素-血管紧张素系统和肾小球旁器信号通路的遗传调控；内在自我调节机制：肌源性信号和小球反馈；动态自动调节和机制的调节；一氧化碳/一氧化氮对肾循环和肾小管运输的调节；交感神经系统、二十烷类化合物、内皮素和氧化应激/活性氧物种；压力钠尿：生理/病理生理学意义和整合动脉压对肾小管功能和钠排泄的影响的分子机制；高血压、糖尿病和代谢综合征中肾血管阻力调节的异常；糖尿病和高血压中的遗传影响；以及肾脏损伤的机制。