Thrombospondins and other Matricellular Proteins in Tissue Organization and Hemeo

组织组织和血红蛋白中的血小板反应蛋白和其他基质细胞蛋白

• 批准号: 7275863
• 负责人: John W LAWLER
• 金额: $ 0.9万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7275863
• 关键词: Adult; Biology; Cardiovascular system; Cell physiology; Collaborations; Connective Tissue; Development; Evolution; Extracellular Matrix Degradation; Future; Goals; Homeostasis; Immune; Inflammation; Investigation; Malignant Neoplasms; Mediating; Nature; Neuroglia; Pathology; Physiology; Protein Family; Proteins; Range; Research; Research Personnel; Role; Scientist; Structure; Thrombospondins; Tissues; Translations; Tumor Biology; Wound Healing; angiogenesis; cell motility; embryo tissue; interest; receptor; relating to nervous system; repaired; symposium

DESCRIPTION (provided by applicant): Matricellular proteins serve unique functions during the formation of embryonic tissue and the repair of adult tissue. These proteins help to modulate cellular migration, survival and proliferation. They also regulate the structure and degradation of the extracellular matrix. Matricellular proteins are abundantly expressed during development, wound healing, inflammation, angiogenesis and cancer. The overall goal of the conference is to bring together researchers with active interests in the biology, physiology and pathology of matricellular proteins with the aims of (1) facilitating discussion and collaboration, (2) accelerating the integration of current research with progress in translation applications and (3) identifying future directions for the investigation of this important family of proteins. The conference sessions will cover a broad range of topics with the roles of matricellular proteins in tissue organization and homeostasis as an overarching theme. The topics to be covered include (1) receptors and cellular networks that mediate the effects of matricellular proteins and (2) the structures and evolution of these proteins. Furthermore, the role of matricellular proteins in (1) tissue genesis and repair, (2) connective tissue structure and function, (3) cardiovascular biology, (4) angiogenesis and tumor biology, (5) neural and glial cell function, and (6) immune cell function will be explored. The interdisciplinary nature of the research on matricellular proteins makes this conference a unique opportunity for scientists in diverse fields to interact.

描述（由申请人提供）：基质细胞蛋白在胚胎组织形成和成体组织修复过程中发挥独特的功能。 这些蛋白质有助于调节细胞迁移、存活和增殖。 它们还调节细胞外基质的结构和降解。 基质细胞蛋白在发育、伤口愈合、炎症、血管生成和癌症期间大量表达。 会议的总体目标是汇集对基质细胞蛋白质的生物学，生理学和病理学感兴趣的研究人员，目的是（1）促进讨论和合作，（2）加速当前研究与翻译应用进展的整合，（3）确定这一重要蛋白质家族研究的未来方向。 会议将涵盖广泛的主题，其中基质细胞蛋白在组织和体内平衡中的作用是一个首要主题。 所涉及的主题包括：（1）介导基质细胞蛋白质作用的受体和细胞网络;（2）这些蛋白质的结构和进化。此外，将探索基质细胞蛋白在（1）组织发生和修复，（2）结缔组织结构和功能，（3）心血管生物学，（4）血管生成和肿瘤生物学，（5）神经和神经胶质细胞功能，以及（6）免疫细胞功能中的作用。基质细胞蛋白质研究的跨学科性质使这次会议成为不同领域科学家互动的独特机会。