Aspen Perinatal Biology Symposium

申请者描述(由申请者提供)：本申请寻求资助12名来自美国的受训人员或新研究人员参加Aspen 2007围产期生物学研讨会的旅费，以及两名美国资深研究人员出席本次会议的旅费和每日费用，他们每人将在会议上发表一次受邀的全体演讲并参加研讨会。美国围产期研究的悠久传统支撑了我们对胎儿发育的生理学基础的了解。细胞和分子技术在过去10年的研究中的结合，使人们能够深入了解胎儿生理学的发育基础，以及先兆子痫、宫内发育迟缓、糖尿病和早产的病理生理学，以及与围产期发病率和死亡率相关的情况。人们迅速认识到，子宫内的生命与成人生活中疾病的发展有关，即健康和成人疾病或胎儿计划的发育起源。这重新引起了人们对围产期生理学的兴趣。围产期研究社区是多学科的；汇集了对母体、胎儿和胎盘生理学感兴趣的临床医生和基础科学家，以及进行与人类生理学和发育密切相关的比较研究的大量农业动物生理学家。它还有着培训年轻的基础和临床科学家的强大传统；他们的培训经验的一个重要部分是有机会在他们可以与资深科学家互动的场所介绍工作，并从榜样那里获得指导的好处。北美围产期研究界特别得到了由FASE B赞助的一系列会议的服务。FASEB赞助的一个条件是严格要求只邀请高级调查人员作为受邀演讲者，并安排包括年轻调查人员和实习生参加海报会议，但不允许他们口头陈述或最大限度地与高级调查人员互动。在上一次围产期生物学会议上，决定组织一次单独的会议，其形式允许年轻调查人员作口头陈述，并有机会与高级调查人员进行更多互动。本次会议将围绕“健康后代的发育和异常发育的长期后果”这一综合主题，由母体、胎儿、胎盘和农业动物研究团体共同发表演讲。会议为期两天半，包括八个口头全体会议，每个会议包括新的研究人员，每个系统两个与健康后代和发育有关的系统。在举行全体会议的同时，还举行了一次讨论有争议问题的互动研讨会。安排了两个3小时的海报讨论会议，并将在整个会议上展示海报，以便有时间深入讨论工作。受训人员或新调查人员的最佳海报演示将获奖。受训人员和新的调查人员将根据科学委员会提交的第一作者摘要进行审查，以奖励旅费。美国的高级调查人员将由会议组织者和这项提案的PI挑选。围产期研究会议总是有很高比例(高达40%)的女性与会者、演讲者和会议主席，以确保有足够的代表。目的本次会议拨款申请的目的是为12名见习生/年轻研究人员提供旅费，以帮助他们参加2007年Aspen围产期生物学研讨会。它还将为两名在美国的资深科学家提供支持，让他们出席会议、作全体发言和参加研讨会。这次会议的主题是“健康后代的发育和发育异常的长期后果”。随着人们越来越多地认识到，子宫内生命是成人生活中疾病的一个主要决定因素，这对公共卫生产生了重大影响。这次会议将以一种综合的方式将产妇、胎儿和胎盘生理学家以及使用与围产期生物学相关的动物模型的农业科学家聚集在一起。

DESCRIPTION (provided by applicant): This application seeks funding for travel costs to allow the attendance of 12 trainees or new investigators from the USA at the Aspen Perinatal Biology Symposium 2007 together with funding to support the travel and per diem costs of two senior US-based investigators to this meeting where they each will present an invited plenary lecture and take part in workshop sessions. The longstanding tradition of perinatal research in the US underpins our knowledge of the physiologic basis of fetal development. Cellular and molecular techniques incorporated into investigation in the last 10 years has allowed in depth understanding of the developmental basis of fetal physiology and the pathophysiology of preeclampsia, IUGR, diabetes and premature delivery, situations associated with perinatal morbidity and mortality. There has been a burgeoning recognition that life in utero is associated with the development of disease in adult life i.e. the developmental origins of health and adult disease or fetal programming. This has brought renewed interest in perinatal physiology. The perinatal research community is multidisciplinary; bringing together clinicians and basic scientists interested in maternal, fetal, and placental physiology and a substantial cadre of agricultural animal physiologists who perform comparative studies of great relevance to human physiology and development. It also has a strong tradition of training young basic and clinician scientists; a vital part of their training experience is the opportunity to present work in venues where they can interact with senior scientists, and receive the benefit of mentorship from role models. The North American perinatal research community specifically has been served by a series of meetings sponsored by FASEB. A condition of FASEB sponsorship is a strict requirement for inclusion of only senior investigators as invited speakers and a schedule including young investigators and trainees in poster sessions but not allowing them oral presentations or maximal opportunities to interact with senior investigators. At the last perinatal biology meeting it was decided to organize a stand alone meeting with a format allowing oral presentations by young investigators and opportunities for more interaction with senior investigators. This meeting will feature presentations from maternal, fetal, placental and agricultural animal research communities together around an integrated theme of "The development of healthy offspring and the long term consequences of abnormal development." The meeting will be 2 1/2 days with eight oral plenary sessions each including new investigators, two for each system related to healthy offspring and development. Plenary sessions are accompanied by an interactive workshop session addressing controversial questions. Two 3-hour poster discussion sessions are scheduled and posters will be displayed for the entire meeting to allow time for in-depth discussion of work. Prizes will be awarded for the best poster presentations by trainees or new investigators. Trainees and new investigators will be selected based on review of submitted first author abstracts by the scientific committee for award of travel funds. The US-based senior investigators will be selected by the meeting organizers and PI of this proposal. There always is a high proportion (up to 40%) of women attendees, speakers and session chairs at perinatal research meetings ensuring adequate representation. Purpose The purpose of this conference grant application is to provide travel funds for 12 trainee/young investigators to help support their attendance at the 2007 Aspen Perinatal Biology Symposium. It will also provide support for two senior US- Based scientists to attend the meeting give a plenary presentation and participate in workshop sessions. The theme of the conference is "The development of healthy offspring and the long term consequences of abnormal development." This has major public health consequences with the growing recognition that life in utero is a major determinant of disease in adult life. The conference will bring together in an integrated manner maternal, fetal and placental physiologists together with agricultural scientists using animal models of relevance to perinatal biology.