2007 Red Cells Gordon Research Conference

描述(由申请人提供)： 红细胞戈登会议为深入讨论与红细胞生物学、红系基因表达调控、造血和临床相关问题有关的话题提供了一个非正式的氛围。这次会议的订阅量一直超额，吸引了来自世界各地的顶尖科学家和临床医生。鉴于最近在几个重要领域取得的重大进展，2007年会议尤其值得注意。计划举行九次个人会议。所有讲座都将包括一个简短的入门讲座，然后是一个主题主旨和四到五个完整的讲座，以及由受训人员或初级调查人员或具有重大意义的最新发现提供的一到两个简短的演讲。戈登会议的一个新组成部分将是整个会议，专门讨论指导红系干细胞成熟的基因调控事件如何转化为这一过程特有的表型转变。我们预计，这将是一次特别及时和活跃的讨论，将利用所有与会者的广泛专业知识，从研究基因调控的人到研究膜结构和生物发生的人。其他主要主题包括几种临床疾病，从疟疾到罕见但鲜为人知的重要疾病。 影响红细胞的疾病，如PNH、钻石黑扇贫血和范可尼贫血。课程主题为：课程1.造血的发育方面；课程2.膜-细胞骨架蛋白的相互作用；课程3.基因表达的全球调控；课程4.转录因子；课程5.红细胞生成过程中蛋白质多样性的控制；课程6.成熟和发育中的红细胞的信号传递；课程7.红系分化中的表型转变 第八节：红细胞膜结构和动力学；第九节：红细胞膜紊乱。下午的海报会议将包括来自所有学科的演讲。科学方法/兴趣的多样性，加上以前红血球戈登会议的丰富讨论，导致了许多富有成效的合作，并促进了基础和临床研究的新发展。同样值得注意的是，我们对蛋白质、膜、细胞生物学和许多疾病的许多最基本的理解都是从对红细胞的研究开始的。红血球戈登会议在促进这些进展方面发挥了重要作用。2007年的会议将延续这一传统。

DESCRIPTION (provided by applicant): The Red Cell Gordon Conference has provided an informal atmosphere for in-depth discussions on topics related to red cell biology, regulation of erythroid gene expression, hematopoiesis, and clinically related issues. The meeting, which is consistently oversubscribed, draws leading scientists and clinicians from around the world. The 2007 meeting should be especially noteworthy, given the major recent advances in several of the prominent areas. Nine individual sessions are planned. All will feature a short introductory lecture, followed by a topical keynote and four or five full lectures, and one or two shorter talks provided by trainees or junior investigators or late-breaking discoveries of major significance. A new component of this Gordon Conference will be an entire session devoted to a conferee-wide discussion of how the gene-regulatory events guiding erythroid stem-cell maturation are translated into the phenotypic transitions characteristic of this process. We anticipate that this will be a particularly timely and lively discussion that will draw on the broad expertise of all in attendance, from those studying gene regulation to those studying membrane structure and biogenesis. Other major topics include several clinical disorders, from malaria to rare but poorly understood and important diseases affecting the red cell, such as PNH, Diamond Blackfan anemia, and Fanconi's anemia. The session topics are: Session 1. Developmental aspects of hematopoiesis; Session 2. Membrane-cytoskeletal protein interactions; Session 3. Global regulation of gene expression; Session 4. Transcription factors; Session 5. Control of protein diversity during erythropoiesis; Session 6. Signaling in mature and developing red cells; Session 7. Phenotypic transition during erythroid differentiation Session 8. Red cell membrane structure and dynamics; Session 9. Red cell disorders. Afternoon poster sessions will feature a mix of presentations from all disciplines. The diversity of scientific approaches/interests combined with the richness of discussions of previous Red Cell Gordon Conferences has led to numerous productive collaborations and fostered new developments in basic and clinical research. It is also noteworthy that many of our most fundamental understandings of proteins, membranes, cell biology, and many diseases began with studies in the red cell. The Red Cell Gordon Conference has played a major role in fostering these advances. The 2007 conference will continue this tradition.