1st Costello Syndrome Symposium

第一届科斯特洛综合症研讨会

• 批准号: 7278088
• 负责人: Katherine Anna Rauen
• 金额: $ 4.6万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-10 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7278088
• 关键词: Advocate; Attention; Basic Science; Benign; Biochemistry; Bioinformatics; California; Cardiac; Cardiology; Characteristics; Child; Clinical; Clinical Investigator; Clinical Management; Clinical Research; Communities; Complex; Costello syndrome; Development; Developmental Delay Disorders; Discipline; Doctor of Medicine; Doctor of Philosophy; Dysmorphology; Endocrinology; Failure to Thrive; Family; Foundations; Future; Genes; Genetic; Goals; HRAS gene; Health Sciences; Human Development; Individual; International; Knowledge; Lead; Learning; Malignant - descriptor; Medical; Molecular; Molecular Genetics; Mutation; Neoplasms; Neurology; Oregon; Participant; Pathogenesis; Pathway interactions; Patients; Pediatric Hospitals; Physicians; Population; Postdoctoral Fellow; Predisposition; Principal Investigator; Regulation; Request for Applications; Research; Research Personnel; San Francisco; Scientist; Skeletal system; Solid; Students; Syndrome; Systemic Therapy; Time; Translational Research; Universities; base; c-Ha-ras p21; craniofacial; developmental disease; direct application; insight; interest; member; oncology; protein function; symposium; tumor progression

DESCRIPTION (provided by applicant): This application requests support for the scientific meeting entitled, "1st International Costello Syndrome Research Symposium 2007". This meeting will be held on July 21, 2007 at the Marion L. Miller Auditorium at Doernbecher Children's Hospital, Oregon Health and Science University, Portland, OR. The principal investigator and co-director of this meeting is Katherine A. Rauen, Ph.D., M.D., of the University of California San Francisco. Organizational and content support will be provided by Ms. Lisa Schoyer, President of the Costello Syndrome Family Network (CSFN) and co-director of the research symposium, and Ms. Dawn Macready-Santos, CSFN Board Member and Chair of the 2007 CSFN meeting to be held concurrently with the research symposium. Costello syndrome (CS) is a complex developmental disorder involving characteristic craniofacial features, failure to thrive, developmental delay, cardiac and skeletal anomalies, and a predisposition to develop neoplasia, both benign and malignant. This symposium will focus on recent, exciting molecular advances in CS including the discovery of the causal gene, HRAS, as well as clinical research and future therapy options for this population of patients. For the first time, a solid foundation for the study of the genetic basis of Costello syndrome will allow basic science researchers and clinicians to begin to understand its pathogenesis. This, in turn, will lead to better treatment and possible therapy. The overall goal of this symposium is to provide an open forum for researchers, clinicians, and physician-scientists to share and discuss basic science and clinical issues setting forth a solid framework for future research, translational applications directed towards therapy and best practices for individuals with CS. Because of the wide phenotypic effect seen in children with CS, formalization of basic science and clinical research through this symposium will not only help gain insight into the cause and progression of cancer, but also into the understanding of how such a gene is involved in the regulation of normal human development. The specific aims of the meeting are 1) meet individuals with CS and learn of their capacities, 2) learn how causative mutations in HRAS alter protein function and how this alteration may contribute to the pathogenesis of CS, 3) inspire clinicians and clinical researchers to consider syndrome specific management of clinical issues, 4) inspire basics science researchers in the Ras and related fields to apply their basic science knowledge to the clinical aspects of CS, 5) begin a formal discussion in the application of Ras pathway modulators as possible systemic therapy for CS individuals, and 6) inaugurate a commitment to research symposia to be an integral part to the bi-annual International Costello Syndrome Family Conferences. The participants are to include basic scientists in the fields of biochemistry, bioinformatics, and molecular genetics, as well as, clinical investigators from disciplines in dysmorphology, cardiology, endocrinology, neurology, oncology, and development. The audience will consist of clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and families, all of whom share an underlying interest in CS. Special attention will be paid to the involvement of junior investigators, trainees (medical/graduate students, post docs and fellows) and clinicians and scientists from underrepresented communities.

描述（由申请人提供）：本申请请求支持题为“2007年第一届国际科斯特洛综合征研究研讨会”的科学会议。本次会议将于2007年7月21日在马里恩L。波特兰，俄勒冈州健康与科学大学，多恩贝彻儿童医院的米勒礼堂。本次会议的主要研究者和联合主任是凯瑟琳A。Rauen博士，医学博士，来自加州旧金山弗朗西斯科大学。科斯特洛综合征家庭网络（CSFN）主席兼研究专题讨论会联合主任丽莎·肖耶女士和CSFN董事会成员兼2007年CSFN会议主席道恩·麦克里迪·桑托斯女士将提供组织和内容支持。 Costello综合征（CS）是一种复杂的发育障碍，涉及特征性颅面特征、发育障碍、发育迟缓、心脏和骨骼异常以及易发生良性和恶性肿瘤。本次研讨会将重点关注CS的最新，令人兴奋的分子进展，包括致病基因HRAS的发现，以及该患者人群的临床研究和未来治疗方案。对于第一次，一个坚实的基础，为研究的遗传基础科斯特洛综合征将允许基础科学研究人员和临床医生开始了解其发病机制。反过来，这将导致更好的治疗和可能的治疗。本次研讨会的总体目标是为研究人员，临床医生和医生科学家提供一个开放的论坛，分享和讨论基础科学和临床问题，为未来的研究，针对CS个人治疗和最佳实践的转化应用提供坚实的框架。由于在CS儿童中观察到的广泛的表型效应，通过这次研讨会，基础科学和临床研究的正规化不仅有助于深入了解癌症的原因和进展，而且还有助于了解这种基因如何参与正常人类发育的调节。会议的具体目标是：1）与CS患者见面并了解他们的能力，2）了解HRAS中的致病突变如何改变蛋白质功能以及这种改变如何有助于CS的发病机制，3）激励临床医生和临床研究人员考虑临床问题的综合征特异性管理，4）激励Ras和相关领域的基础科学研究人员将他们的基础科学知识应用于CS的临床方面，5）开始正式讨论Ras途径调节剂作为CS个体的可能的全身治疗的应用，和6）开创一个承诺，研究研讨会是一个组成部分，每两年一次的国际科斯特洛综合征家庭会议。参与者包括生物化学、生物信息学和分子遗传学领域的基础科学家，以及来自畸形学、心脏病学、内分泌学、神经病学、肿瘤学和发育学科的临床研究人员。观众将包括临床医生，基础科学家，医生科学家，倡导领导者，学员，学生和家庭，所有这些人都对CS有着潜在的兴趣。将特别注意来自代表性不足社区的初级调查员、受训人员（医学/研究生、博士后和研究员）以及临床医生和科学家的参与。