2007 Motile and Contractile Systems

描述（由申请人提供）：部分支持要求为2007年戈登研究会议的运动和收缩系统将于2007年7月8日至7月13日在科尔比索耶学院在新罕布什尔州。本次会议的目的是鼓励在细胞骨架研究前沿工作的科学家社区内转移思想和信息，细胞骨架研究长期以来被认为是理解基本生物过程的关键领域。细胞骨架元素是真核生物生命所必需的，对细胞运动、细胞信号传导、膜运输、细胞分裂、细胞极性和多细胞生物体的发育做出重要贡献。肌动蛋白、微管和马达对于许多正常生理功能包括伤口愈合、病原体-细胞相互作用、细胞介导的免疫和胚胎发生是重要的。此外，细胞骨架缺陷导致许多病理性人类病症，包括肌肉骨骼和神经退行性疾病、肿瘤发生、呼吸系统疾病、不孕症以及先天性失明和耳聋。2007年的会议将集中讨论活细胞中细胞骨架元素的动力学，以及这些复合物在细胞运动、膜结合囊泡和mRNA的细胞内运输、染色体分离和细胞分裂以及活生物体内细胞运动中的功能。只要有可能，讨论基本细胞骨架过程的数学建模的会谈也将包括在内。由于其广度和跨学科的性质，运动和收缩系统戈登会议继续在该领域发挥着开创性的作用，尽管亚专业会议的扩散。大约60名杰出的研究科学家将在八个讲座/讨论会上作正式演讲。大约三分之一的演讲将从提交的摘要中选出，以鼓励优秀的新研究人员，博士后和学生的参与。将鼓励不作口头发言的与会者以海报形式介绍其最近的工作。

DESCRIPTION (provided by applicant): Partial support is requested for the 2007 Gordon Research Conference on Motile and Contractile Systems to be held July 8- July 13, 2007 at Colby-Sawyer College in New Hampshire. The purpose of this conference is to encourage the transfer of ideas and information within the community of scientists who work at the forefront of cytoskeleton research, an area that has long been recognized as critical for understanding fundamental biological processes. Cytoskeletal elements are essential for life in eukaryotes, making central contributions to cell motility, cell signalling, membrane trafficking, cell division, cell polarity, and the development of multicellular organisms. Actin, microtubules and motors are important for many normal physiological functions including wound healing, pathogen-cell interactions, cell-mediated immunity and embryogenesis. Moreover, cytoskeletal defects underlay many pathological human conditions including musculoskeletal and neurodegenerative diseases, oncogenesis, respiratory diseases, infertility, and congenital blindness and deafness. The 2007 conference will focus on dynamics of cytoskeletal elements in living cells, and the functions of these complexes in cell locomotion, intracellular transport of membrane-bounded vesicles and mRNAs, chromosome segregation and cell division, and cellular movement within living organism. Wherever possible, talks that discuss mathematical modeling of basic cytoskeletal processes will also be included. Because of its breadth and interdisciplinary nature, the Motile and Contractile Systems Gordon Conference has continued to play a seminal role in the field, despite the proliferation of subspecialty meetings. Approximately 60 outstanding research scientists will make formal presentations in eight lecture/discussion sessions. About one-third of these presentations will be selected from the submitted abstracts to encourage participation by outstanding new investigators, postdocs and students. Conferees that do not make oral contributions will be encouraged to present their recent work in a poster format.