Neuroprotection and Promotion of Repair Following Neurotoxic Injury

神经毒性损伤后的神经保护和修复促进

• 批准号: 7277576
• 负责人: Isaac N Pessah
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7277576
• 关键词: Address; Adult; Affect; Aging; Air Pollution; Area; Autistic Disorder; Behavior; California; Communities; Development; Endocrine disruption; Exposure to; Goals; Health; Human; Injury; International; Modeling; Nerve Degeneration; Nervous system structure; Neurologic; Oral; Organism; Oxidative Stress; Participant; Potassium Channel; Predisposition; Range; Recovery; Request for Proposals; Research; Research Personnel; Resolution; Risk Assessment; Role; Screening procedure; Series; Students; central nervous system injury; day; indium arsenide; lectures; neurobehavioral test; neuroprotection; neurotoxic; neurotoxicity; neurotoxicology; nitrone; posters; programs; repaired; symposium

DESCRIPTION (provided by applicant) This proposal requests partial support for the 11th International Neurotoxicology Association's biennial meeting (INA-11) to be held at the Asilomar Conference Center in Pacific Grove, California June 10-15, 2007. The broad and long-term goal of the conference is to increase our understanding of fundamental and applied aspects of neurotoxicology, with a strong emphasis on mechanisms of injury and strategies for promoting neuroprotection and recovery from injury. The specific aims of this meeting will be to convene 35 invited speakers from around the globe that represent critical areas of neurotoxicological research with a total of 200 participants for a five day conference in a relatively isolated setting. The program will commence Sunday evening with a keynote lecture by Dr. Fred Gage entitled "Promoting Recovery from Central Nervous System Injury in the Adult Organism". Eight sessions will broadly address current issues in the field. Two sessions on Monday will focus on the neuroprotective role of metallothioneins, neurosteroids, potassium channels, and nitrones. Two sessions on Tuesday will present advances in neurotoxicity screening in mammalian and non-mammalian models, and a third on Thursday morning addresses progress toward using neurobehavioral testing in human risk assessment. The remaining three sessions commencing Thursday afternoon and ending midday Friday address new neurotoxicological concerns including immunological and neurodevelopmental susceptibilities contributing to autism, air pollution, oxidative stress, and neurodegeneration, and how endocrine disruption influences the development of sexually dimorphic nervous systems and associated behaviors. In addition, a symposium organized and presented by students participating in graduate programs in neurotoxicology will round out the oral presentations. Two evening poster sessions will permit all participants to contribute to these topics. A committee will be constituted. The significance of this application is that the INA Conference series has become a major venue that propel research in the international community of researchers and educators involved in all aspects of neurotoxicology. The health relatedness of this application is that the discussions stimulated by the presentations will define the major questions that require experimental resolution in areas that affect human neurological heath, ranging from developmental exposures to degeneration associated with the aging nervous system.

描述（由申请人提供） 该提案要求在2007年6月10日至15日在加利福尼亚州太平洋格罗夫市的Asilomar会议中心举行第11个国际神经毒理学协会的两年一月会议（INA-11）。会议的广泛和长期目标是增加我们对神经毒理学的基本和应用方面的理解，并促进了对策略的攻击，并促进了对策略的攻击，并提高了我们对基本和应用方面的理解。这次会议的具体目的是召集来自世界各地的35名受邀演讲者，代表神经毒理学研究的关键领域，共有200名参与者在相对孤立的环境中进行为期五天的会议。该计划将在周日晚上开始，弗雷德·盖奇（Fred Gage）博士的主题演讲为“促进成人有机体中枢神经系统损伤的康复”。 八个会议将广泛解决该领域的当前问题。周一的两次会议将重点介绍金属硫硫蛋白，神经固醇，钾通道和硝基的神经保护作用。周二的两次会议将介绍哺乳动物和非哺乳动物模型的神经毒性筛查的进展，而周四早晨的第三个会议将解决在人类风险评估中使用神经行为测试的进展。剩下的三场会议将于周四下午开始，结束周五的结束，解决了新的神经毒理学问题，包括免疫学和神经发育的敏感性，有助于自闭症，空气污染，氧化压力和神经变性以及内分泌干扰如何影响性影响性二聚态神经系统和相关行为的发展。 此外，由参加神经毒理学研究生课程的学生组织和介绍的研讨会将详尽。两个晚上的海报会议将使所有参与者都可以为这些主题做出贡献。委员会将成立。该应用程序的重要性是，INA会议系列已成为推动参与神经毒理各个方面的研究人员和教育工作者的研究的主要场所。该应用的健康相关性是，演示文稿刺激的讨论将定义需要在影响人类神经系统的领域进行实验分辨率的主要问题，从发育暴露到与衰老神经系统相关的退化。