ANIMAL MODELS OF AUTISM

自闭症动物模型

• 批准号: 7349675
• 负责人: Isaac N Pessah
• 金额: $ 4.97万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349675
• 关键词: ANIMAL; MODELS; AUTISM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: We will explore the effects of prenatal hyperphenylalaninemia on the developing brain. Phenylketonuria (PKU) is a genetic disorder of metabolism involving the failed conversion of phenylalanine to tyrosine. Accumulated amounts of phenylalanine early in development result in a condition know as hyperphenylalaninemia which is characterized by social, cognitive, and motor deficits similar to those observed in the autistic syndrome. Animal models of hyperphenylalaninemia have been described in both rodents and primates and are characterized by social and cognitive deficits similar to those observed in the human condition. In addition, research on rodent models of hyperphenylalaninemia have demonstrated abnormalities in serotonin synthesis in the cerebral cortex and cell loss in the cerebellum similar to the pathology reported in the brains of autistic patients. Much remains to be learned about the pathogenesis of excess amounts of phenylalanine on the developing brain, however, especially concerning the relationship between pathology and observed symptoms.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。目的：我们将探讨产前多苯基丙氨酸血症对发育中大脑的影响。苯酮尿症（PKU）是一种新陈代谢的遗传疾病，涉及苯丙氨酸转化为酪氨酸的失败。发育早期的积累苯丙氨酸量会导致一种称为过苯丙氨酸血症的疾病，其特征是社会，认知和运动缺陷，类似于自闭症综合征中观察到的衰竭。在啮齿动物和灵长类动物中已经描述了多苯基丙氨酸的动物模型，其特征是社会和认知缺陷，类似于在人类状况下观察到的缺陷。 此外，对多苯基丙氨酸的啮齿动物模型的研究表明，大脑皮层中5-羟色胺合成和小脑细胞损失的异常，类似于自闭症患者的大脑中报道的病理学。然而，关于发育中的大脑过量过量的发病机理，尤其是关于病理学与观察到的症状之间的关系，还有很多尚待了解。