Materials and Strategies for Lab-on-a-Chip

描述(由申请人提供)： 本次研讨会的目的是讨论芯片实验室设备的材料和工程方面，以及微流控技术在材料合成中的应用。在单个芯片上集成生物样品处理和检测的微流控系统(单芯片实验室)提供了低成本、快速和高性能分析的前景。能够操作和分析含有颗粒、细胞或大生物分子的复杂流体的微型设备可以执行高通量生化分析以用于药物发现，并为医疗保健诊断和生物治疗监测提供便携性。微流控芯片也正在成为材料操纵和制造的工具。操纵液滴的装置被用来进行各种分析和合成颗粒和颗粒组件。定向液流用于组装或合成原位纳米器件和纳米电路。芯片实验室设备通常采用微电子行业的技术制造，是广泛的多学科研究的主题。构建块的开发已经取得了重大进展，但在同一芯片上实现多种功能的高度集成仍然是一个挑战。为了实现“完整的”集成系统，必须解决的许多剩余问题都与材料有关。需要新的方法来克服非特定表面相互作用或异质表面化学等问题，并实现低成本制造、超灵敏量化、纳米级操纵和界面连接。 感兴趣的主题包括但不限于以下领域： 微细加工和生物相容性优化的材料 用于特殊附着力、配体固定化和防污的涂层 芯片上的流体传输、混合、分离、过滤以及与检测方案的集成 复杂生物基质(血液、食品和环境样品)的片上样品预浓缩和处理 胶体颗粒的片上操纵和组装 芯片上的功能纳米结构 微流控装置中复合粒子和胶囊的合成 微流体流组装纳米线和电子纳米器件 微米和纳米尺度的流体现象以及芯片实验室设备中复杂流体行为(液滴、悬浮液和生物系统)的理论建模 微型和纳米流体应用的制造技术的进展，如纳米压印光刻 片上检测方法 世界到芯片接口

DESCRIPTION (provided by applicant): The goal of this symposium is to discuss material and engineering aspects of lab-on-a-chip devices and the application of microfluidics to materials synthesis. A microfabricated fluidic system integrating biological sample treatment and detection on a single chip (lab-on-a-chip) offers the promise of low-cost, rapid, and high-performance analysis. Miniaturized devices capable of manipulation and analysis of complex fluids containing particles, cell, or large biomolecules can perform high-throughput biochemical assays for drug discovery as well as provide portability for point-of-care diagnostics and biothreat monitoring. Microfluidic chips are also becoming a tool for materials manipulation and fabrication. Devices manipulating droplets are used to carry out various assays and to synthesize particles and particle assemblies. Directed liquid flows are used to assemble or synthesize in-situ nanodevices and nanocircuits. Lab-on-a-chip devices are usually fabricated using technologies adapted from the microelectronics industry and are the topic of extensive multidisciplinary research. Significant progress has been made in the development of building blocks, but attaining a high degree of integration of multiple functions on the same chip remains a challenge. Many of the remaining issues that must be addressed to allow "complete" integrated systems are materials related. New approaches are required to overcome problems such as nonspecific surface interactions or heterogeneous surface chemistries, and to achieve low-cost manufacturing, ultrasensitive quantification, nanoscale manipulation, and interfacing. Topics of interest include, but are not limited to, the following areas: Materials optimized for microfabrication and biocompatibility Coatings for specific adhesion, ligand immobilizations, and antifouling On-chip fluid transport, mixing, separation, filtration, and integration with detection schemes On-chip sample preconcentration and treatment of complex biological matrices (blood, food, and environmental samples) On-chip manipulation and assembly of colloidal particles Functional nanostructures on a chip Synthesis of complex particles and capsules in microfluidic devices Assembly of nanowires and electronic nanodevices by microfluidic flows Theoretical modeling of fluidics phenomena at the micro- and nanoscale as well as of complex fluid behavior (droplets, suspensions, and biological systems) in lab-on-a-chip devices Advances in fabrication techniques, such as nanoimprint lithography, for micro- and nanofluidic applications On-chip detection approaches World-to-chip interface