The Molecular and Integrative Basis for Gastrointestinal Development, Homeostasis

在R13机制下请拨经费，为第十二个两年期提供部分支助 FASEB夏季会议的重点是胃肠道生物学，题为胃肠道XII： 胃肠道发育、稳态和疾病的分子和整合基础。 会议将于2007年8月11日至16日在科罗拉多州的斯诺马斯举行。启动时间： 1985年，这些会议已成为讨论 在一次小型会议上进行与胃肠健康和疾病相关的前沿研究 格式(100-200人)。计划性组织的两个独特方面 为该领域提供特殊价值。一个规划目标是将研究人员聚集在一起 在不同的领域工作，允许思想的交叉培养，因此有一套广泛的 会议讨论了各种主题。这是我们参加的唯一一种小型会议形式 意识到这对胃肠道研究做出了贡献。九大科学 会议将围绕以下主题组织：采用比较办法 了解胃肠道功能、干细胞、发育和分化 隐窝/绒毛轴，胃肠道病原体，炎症性肠病，癌症，离子 运输/屏障与IBD疾病的遗传学第二个规划目标是 积极促进基础和临床科学家之间的互动。这是通过以下方式实现的 利用每一次会议讨论跨越健康的分子和细胞基础的主题 在胃肠道的疾病，并再次促进了小型会议的形式。从科学上讲， 目标是(1)在消化系统研究的前沿提供科学规划 疾病和相关领域，围绕这些疾病的基本病理生理学组织 疾病及其预防机制，以及(2)整合 分子水平上的信息将阐明 定义胃肠道的器官水平行为。该计划的组织是为了 增强初级调查人员(学生、研究员和 助理教授职级以下的教师)，将他们纳入讲课 作为一场抽象驱动的初级阶段竞赛的结果，在短篇演讲中的节目 调查员议长奖。我们的资金申请是专门为了支持这个奖项。 该计划允许更多初级调查人员积极参与该计划。

Funding is requested under the R13 mechanism in partial support for the twelfth biennial FASEB summer conference focused on gastrointestinal biology, entitled ¿GI Tract XII: The Molecular and Integrative Basis for GI Development, Homeostasis and Disease¿. The meeting will be held in Snowmass Colorado on August 11-16, 2007. Initiated in 1985, these conferences have become one of the premier venues for the discussion of cutting-edge research related to gastrointestinal health and disease in a small meeting format (100-200 attendees). Two unique aspects of the programmatic organization provide special value to the field. One programmatic goal is to bring together researchers working in disparate fields to allow cross-fertilization of ideas, therefore a broad set of topics is covered at the meeting. This is the only small-meeting format of which we are aware that makes this contribution to gastrointestinal research. The nine scientific sessions will be organized around the topics of: Comparative Approaches to Understanding GI Function, Stem Cells, Development, Differentiation Along the Crypt/Villus Axis, Gastrointestinal Pathogens, Inflammatory Bowel Disease, Cancer, Ion Transport/Barrier, and The Genetics of IBD Disorders The second programmatic goal is active promotion of interactions between basic and clinical scientists. This is achieved by using each session to address topics spanning the molecular and cellular basis of health to disease in the GI tract, and again is facilitated by a small-meeting format. Scientifically, goals are to (1) provide scientific programming at the forefront of research in digestive diseases and related areas, organized around the underlying pathophysiology of these diseases and the mechanisms that afford protection against them, and (2) to integrate information at the molecular level that will shed light on regulatory mechanisms that define the organ-level behavior of the gastrointestinal tract. The program is organized to enhance the experience and involvement of junior investigators (students, fellows, and faculty up to the rank of Assistant Professor), by incorporating them into the lecture program in short lectures as a result of an abstract-driven competition for Junior Investigator Speaker awards. Our funding request is specifically to support this award program allowing more Junior Investigators to participate actively in the program.