BioPAX - Biological Pathway Community Workshop

BioPAX - 生物途径社区研讨会

• 批准号: 7168021
• 负责人: CHRIS SANDER
• 金额: $ 1万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-10 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7168021
• 关键词: Adopted; Adoption; Alcohols; Binding; Biological; Biological Models; Biological Process; Biology; Class; Communities; Community Developments; Community Participation; Computer software; DNA; Data; Databases; Development; Educational workshop; Fees; Funding; Future; Genbank; Gene Expression Regulation; Generic Drugs; Genes; Genetic; Genetic Epistasis; Genus Mentha; Goals; Growth; Imagery; Information Systems; Language; Lead; Licensing; Location; Maps; Memorial Sloan-Kettering Cancer Center; Metabolic Pathway; Modeling; Molecular; National Institute of General Medical Sciences; New York; Participant; Pathway interactions; Phosphotransferases; Post-Translational Protein Processing; Problem Solving; Process; Research; Resources; Series; Signal Pathway; Signaling Pathway Gene; Software Tools; Standards of Weights and Measures; System; Systems Biology; Time; Training; Wit; Work; base; biological research; cost; data integration; data modeling; day; interest; mathematical model; member; news; open source; symposium; tool; transcription factor

DESCRIPTION (provided by applicant) Pathway information is vital for understanding biological systems. Unfortunately, the over 170 online pathway data resources vary widely in coverage and representation of biological processes, making their use for biological problem solving extremely difficult. The BioPAX group was formed by the pathway database community in November 2002 to develop a standard biological pathway data exchange format to solve this issue through a series of small workshops. This has resulted in the development of the community accepted, open-source BioPAX level 1 exchange format, which supports metabolic pathway data and BioPAX level 2, which adds support for molecular interaction data. We seek support for a workshop series for the years 2006, 2007 and 2008. The goals of this meeting series are to expand the BioPAX data model by adding support for signaling pathways, gene regulation networks and genetic interactions, such as epistasis; to increase database and tool support for.BioPAX; and to encourage the growth of publicly accessible pathway data and its application to biological problems. We propose to hold BioPAX workshops twice a year, each lasting two days. These will focus on achieving our goals through BioPAX data model and community development discussions. One workshop per year will include a symposium of invited speakers discussing their pathway related computational research. Meetings will include a hackathon, where computer software, such as database converters, is collaboratively developed. Meetings will be hosted by participants and locations will cycle through SRI, Menlo Park, CA (Peter Karp), Cold Spring Harbor Labs, New York, NY (Lincoln Stein) and Memorial-Sloan Kettering Cancer Center, New York, NY (Chris Sander) or other convenient US locations. All meetings will be open to community participation and all minutes and resulting work is freely available under open source terms via the www.biopax.org website.

描述（由申请人提供）通路信息对于理解生物系统至关重要。不幸的是，超过170个在线途径数据资源在生物过程的覆盖范围和代表性方面差异很大，这使得它们用于解决生物问题变得非常困难。BioPAX小组由生物学途径数据库社区于2002年11月成立，旨在通过一系列小型研讨会开发标准生物学途径数据交换格式以解决这一问题。这导致了社区接受的开源BioPAX 1级交换格式的发展，该格式支持代谢途径数据，BioPAX 2级增加了对分子相互作用数据的支持。我们寻求对2006年、2007年和2008年系列讲习班的支持。该系列会议的目标是通过增加对信号通路、基因调控网络和遗传相互作用（如上位性）的支持来扩展BioPAX数据模型;增加对BioPAX的数据库和工具支持;并鼓励公众可访问的通路数据的增长及其在生物学问题中的应用。我们建议每年举办两次BioPAX研讨会，每次为期两天。这些将侧重于通过BioPAX数据模型和社区发展讨论实现我们的目标。每年的一个研讨会将包括一个专题讨论会，邀请演讲者讨论他们的途径相关的计算研究。会议将包括一个黑客会议，在那里合作开发计算机软件，如数据库转换器。会议将由与会者主持，地点将在SRI，门洛帕克，加利福尼亚州（彼得卡普），冷泉港实验室，纽约，纽约州（林肯斯坦）和纪念斯隆凯特琳癌症中心，纽约，纽约州（克里斯桑德）或其他方便的美国地点循环。所有会议都将对社区参与开放，所有会议记录和由此产生的工作都可以通过www.biopax.org网站根据开源条款免费获得。