Matrix Metalloproteinases Gordon Conference

基质金属蛋白酶戈登会议

• 批准号: 7029006
• 负责人: Carl Peter Blobel
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7029006
• 关键词: ADAMTS; Age; Aging; American Association of Cancer Research; Aneurysm; Area; Arthritis; Atherosclerosis; Attention; Biochemistry; Bone Resorption; Cardiovascular system; Cells; Cellular biology; Chemicals; Collaborations; Complementary DNA; Condition; Corneal Ulcer; Data; Development; Discipline; Disease; Encephalomyelitis; Endopeptidases; Enzymes; Extracellular Matrix; Extracellular Matrix Degradation; Eye diseases; Family; Fees; Fibrosis; Fostering; Funding; Gelatinase A; Gene Expression Regulation; Gene Family; Genes; Genetic; Glomerulonephritis; Goals; Homologous Gene; Human; Infection; Inflammation; Influentials; Infusion procedures; International; Length; Literature; Lung; Malignant Neoplasms; Matrix Metalloproteinases; Memory; Metalloproteases; Metalloproteinase Gene; Molecular; Montana; Morphogenesis; Nervous system structure; Neurodegenerative Disorders; Numbers; Ovulation; Participant; Pathology; Peptide Hydrolases; Periodontitis; Physicians; Physiological; Physiology; Plants; Play; Positioning Attribute; Postdoctoral Fellow; Proteins; Proteomics; Purpose; Range; Reagent; Receptor Activation; Relative (related person); Research; Research Personnel; Resort; Role; Scientist; Skiing; Stem Cell Development; Stromelysin 1; Structure; Students; System; Tadpoles; Technology; Tissues; Travel; Ulcer; Work; Wound Healing; abstracting; career; collagenase; enzyme activity; enzyme substrate; fly; inhibitor/antagonist; interest; member; microorganism; natural Blastocyst Implantation; next generation; planetary Atmosphere; posters; programs; structural biology; symposium; therapeutic target

DESCRIPTION (provided by applicant): Gordon Research Conferences bring together active researchers in a selected scientific field with the purpose of defining and analyzing important problems, recent advances and opportunities for research through both formal presentations and extensive discussion. The specific aim of this proposal is to obtain partial funding for the 2005 Gordon Research Conference on Matrix Metalloproteinases (MMPs) and for the conferences in 2007 and 2009. The 2005 Conference represents the 7th biennial meeting of the MMP Gordon Research Conference, and will be held at Big Sky Resort, Big Sky, Montana. MMPs and their relatives play a central role in normal development and physiology and in many pathological conditions associated with tissue destruction, including cancer, arthritis, periodontitis, ulcerations, atherosclerosis, lung fibrosis, degenerative eye diseases, infection and inflammation. The conference will continue to provide a forum for discussion of the latest advances in structure, function, targets, inhibitors and molecular mechanisms. The goal is to create an atmosphere that will weave threads among investigators with common interests, and cross-fertilize those with more diverse approaches. The .2005 conference will consist of eight Scientific Sessions: 1. The Metalloproteinase Toolbox: Structural Biology of Enzymes and Substrates; The Degradome, Visualizing MMPs; 2. Metalloproteinases in Stem Cells, Development and Ageing; 3. Metalloproteinases In Inflammation; 4. Metalloproteinases in The Nervous System-Neurodegenerative Diseases, Memory and Aging; 5. ADAM and ADAMTS Families In Development And Disease; 6. Metalloproteinases in Cancer; 6. Inhibitors Of Metalloproteinases-TEVIPs And Others; 8, Metalloproteinase Gene Regulation, Cell Biology, Activation And Receptors; 9. MMPs-The Next Generation. Two Poster Sessions are planned for the conference to encourage students, postdoctoral fellows and young investigators to join senior investigators in presenting their work. All meeting participants will be encouraged to submit an abstract for the Poster Sessions, allowing all attendees the opportunity to present data and fully participate in discussions. Traditionally, this conference brings together a diverse international group of academic and industrial scientists with interests ranging from basic molecular, cellular and physiological mechanisms MMP action, to physician-scientists interested in MMPs as therapeutic targets. The limited attendance, focused Scientific Sessions, and highly successful Poster Sessions combine to provide an exciting forum for the exchange of ideas and to provide extensive opportunities for participation by a diverse group of scientists interested in MMPs, related enzymes and their inhibitors. Therefore, we are requesting funds to partially support the GRC on MMPs to assure that the most relevant and up-to-date information is featured at this pivotal and highly influential meeting.

描述(由申请者提供)：戈登研究会议汇集了选定科学领域的活跃研究人员，目的是通过正式陈述和广泛讨论来定义和分析重要问题、最新进展和研究机会。这项提议的具体目的是为2005年戈登基质金属蛋白酶研究会议以及2007年和2009年的会议获得部分资金。2005年的会议代表了第七次两年一度的MMP Gordon研究会议，将在蒙大拿州Big Sky的Big Sky Resort举行。MMPs及其近亲在正常发育和生理以及许多与组织破坏相关的病理情况中发挥核心作用，包括癌症、关节炎、牙周炎、溃疡、动脉粥样硬化、肺纤维化、退行性眼病、感染和炎症。会议将继续为讨论结构、功能、靶点、抑制剂和分子机制的最新进展提供一个论坛。目标是创造一种氛围，在有共同兴趣的调查人员之间编织线索，并让那些拥有更多样化方法的人交叉受精。2005年的会议将包括八个科学会议：1.金属蛋白酶工具箱：酶和底物的结构生物学；6.降解组，使基质金属蛋白可视化；2.干细胞中的金属蛋白酶，发育和老化；3.炎症中的金属蛋白酶；4.神经系统中的金属蛋白酶--神经退行性疾病、记忆和衰老；5.ADAM和ADAMTS家族在发育和疾病中；6.癌症中的金属蛋白酶；6.金属蛋白酶的抑制物--TEVIPs和其他；8.金属蛋白酶基因调节、细胞生物学、激活和受体；9.基质金属蛋白酶--下一代。会议计划举行两次海报会议，以鼓励学生、博士后研究员和年轻研究人员与高级调查人员一起介绍他们的工作。将鼓励所有与会者为海报会议提交摘要，使所有与会者都有机会介绍数据并充分参与讨论。传统上，这次会议聚集了不同的国际学术和工业科学家小组，他们的兴趣范围从基本的分子、细胞和生理机制，到对MMPs感兴趣的内科科学家作为治疗目标。有限的出席人数、集中的科学会议和非常成功的海报会议相结合，为思想交流提供了一个令人兴奋的论坛，并为对MMPs、相关酶及其抑制剂感兴趣的不同科学家群体提供了广泛的参与机会。因此，我们请求资金部分支持GRC关于MMP的计划，以确保在这次关键和极具影响力的会议上展示最相关和最新的信息。