Genetic Networks controlling Lymphocyte differentiation

控制淋巴细胞分化的遗传网络

• 批准号: nhmrc : 1003049
• 负责人: Prof Stephen Nutt
• 金额: $ 4.28万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-networks-controlling-lymphocyte-differentiation/108888
• 关键词: Genetic; Networks; controlling; Lymphocyte; differentiation

The cell types of the blood, such as red and white blood cells, are produced in the bone marrow from a rare stem cell. The stem cell uses a handful of important master-regulatory genes that act in a hierarchy to promote the blood cell differentiation process. This research aims to understand how these master-regulators function in isolation and together in producing the white blood cells that are required for our immune response to microbes, vaccination and to prevent cancer.

血液的细胞类型，如红细胞和白色细胞，是由骨髓中一种罕见的干细胞产生的。干细胞使用少数重要的主调节基因，这些基因以分级方式起作用，以促进血细胞分化过程。这项研究的目的是了解这些主调节器是如何单独发挥作用的，以及如何共同产生白色血细胞，这些血细胞是我们对微生物、疫苗接种和预防癌症的免疫反应所必需的。