Genetic networks in lymphocytes

淋巴细胞中的遗传网络

• 批准号: nhmrc : GNT1058238
• 负责人: Prof Stephen Nutt
• 金额: $ 72.76万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-networks-lymphocytes/1344633
• 关键词: Genetic; networks; lymphocytes

The cell types of the blood, such as red and white blood cells, are produced in the bone marrow from a rare stem cell. The stem cell uses a handful of important master-regulatory genes that act in a hierarchy to promote the blood cell differentiation process. This research aims to understand how these master-regulators function in isolation and together in producing the white blood cells that are required for our immune response to microbes, vaccination and to prevent cancer.

血液的细胞类型，如红血球和白血球，是由一种罕见的干细胞在骨髓中产生的。干细胞使用几个重要的主调控基因，这些基因以层次结构的方式作用于促进血细胞分化的过程。这项研究旨在了解这些主调节因子如何单独和共同作用，产生我们对微生物的免疫反应、疫苗接种和预防癌症所需的白细胞。