Gene regulatory networks controlling lymphocyte differentiation

控制淋巴细胞分化的基因调控网络

• 批准号: nhmrc : 1058238
• 负责人: Prof Stephen Nutt
• 金额: $ 44.33万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/gene-regulatory-networks-lymphocyte-differentiation/454662
• 关键词: Gene; regulatory; networks; controlling; lymphocyte

The cell types of the blood, such as red and white blood cells, are produced in the bone marrow from a rare stem cell. The stem cell uses a handful of important master-regulatory genes that act in a hierarchy to promote the blood cell differentiation process. This research aims to understand how these master-regulators function in isolation and together in producing the white blood cells that are required for our immune response to microbes, vaccination and to prevent cancer.

血液的细胞类型，例如红细胞和白细胞，是由罕见的干细胞在骨髓中产生的。干细胞使用一些重要的主调控基因，这些基因按层次结构发挥作用，以促进血细胞分化过程。这项研究旨在了解这些主调节因子如何单独发挥作用，以及如何共同产生白细胞，这些白细胞是我们对微生物的免疫反应、疫苗接种和预防癌症所需的。