Insulin-like Growth Factors in Physiology and Disease

描述(申请人提供)：戈登生理学和疾病中的胰岛素样生长因子研究会议计划于2003年3月、2005年3月和2007年3月在加利福尼亚州文图拉举行。胰岛素样生长因子、胰岛素样生长因子受体和胰岛素样生长因子结合蛋白目前是众多领域密集研究的焦点，并与包括癌症和糖尿病在内的几种代谢和疾病状态有关。这些会议计划将代表胰岛素样生长因子生物学的重要新研究的核心，旨在促进对胰岛素样生长因子调节和信号机制感兴趣的研究人员与对癌症、发育、生理、内分泌和新陈代谢方面的胰岛素样生长因子感兴趣的研究人员之间的互动。 2003年的方案包括关于IGFS在发展中和在细胞转化中的开场白。关于IGFS和癌症这一迅速崛起的领域的几个会议将涵盖流行病学和基本机制，重点是乳腺癌和前列腺癌。其他课程包括IGF信号及其与胰岛素信号的异同、IGFS在代谢性疾病中的作用、IGFs及其受体的分子生物学、IGFPs及其蛋白的作用以及IGFs在特定组织中的功能，包括骨和生殖组织。会议的闭幕式将聚焦于非常新的、令人兴奋的话题--胰岛素/胰岛素样生长因子信号在调节寿命和衰老中的作用。计划于2005年和2007年举行的后续会议将集中讨论IGF信号的当前发展以及关键细胞和疾病过程中的监管。这些会议的一个重要优势是，IGFS的生物学引起了许多学科的研究人员的兴趣。IGF Gordon研究会议将是促进对IGF生物学感兴趣的研究人员和对癌症发生和代谢紊乱感兴趣的研究人员之间的互动的关键机制。这种相互作用对于快速了解IGF配体、受体和结合蛋白的不同功能和调节及其在正常组织功能和疾病中的作用至关重要。

DESCRIPTION (provided by applicant): Gordon Research Conferences on Insulin-like Growth Factors in Physiology & Disease are planned for March 2003, March 2005 and March 2007 in Ventura, California. The IGFs, IGF receptors and the IGF binding proteins currently are the focus of intense investigation across numerous fields and have been implicated in several metabolic and disease states including cancer and diabetes. The conference programs will represent the core of important new research in IGF biology and will be designed to foster interactions between investigators interested in mechanisms of IGF regulation and signaling and those interested in the IGFs in cancer, development, physiology, endocrinology and metabolism. The program for 2003 includes opening presentations on the IGFs in development and in cell transformation. Several sessions on the rapidly emerging area of IGFs and cancer will cover epidemiology and basic mechanisms with a focus on breast and prostate cancer. Other sessions include IGF signaling and the similarities/differences with insulin signaling, the role of IGFs in metabolic diseases, the molecular biology of the IGFs and receptors, the actions of the IGFBPs and their proteases, and the function of IGFs in specific tissues including bone and reproductive tissues. The closing session of the conference will focus on the very new, exciting topic of insulin/IGF signaling in the regulation of life-span and aging. Subsequent meetings that are planned for 2005 and 2007 will focus on current developments in IGF signaling and regulation in critical cellular and disease processes. A significant strength of these conferences is that the biology of the IGFs is of interest to investigators across numerous disciplines. The IGF Gordon Research Conference will be a critical mechanism to promote interaction between investigators interested in IGF biology and those interested in carcinogenesis and metabolic disorders. Such interactions will be essential for rapid progress in understanding the diverse functions and regulation of the IGF ligands, receptors and binding proteins an their roles in normal tissue function and in disease.