Characterising and modelling a continuous tabletting line using Process Analytical Technology (PAT) and Positron Emission Particle Tracking (PEPT)

与更传统的分批单元操作相比，连续处理提供了许多优势，例如：降低了运营成本，提高了敏捷性，以及减少了工厂占地面积。连续直接压缩(CDC)是一种寻求将输入材料转化为片剂的连续过程。连续制造技术的关键优势之一是它们可以与过程分析技术(PAT)相结合。PAT传感器随后可以用来快速了解给定的片剂配方如何响应工艺参数的变化，因此可以建立稳健的工作范围。此外，能够使用通过PAT构建的模型来实时监控混合均匀度，这可以构成最终质量控制策略的关键部分。成功的候选人将通过实验、数据分析和使用人工智能建模技术的组合，成为为持续稳定的过程开发PAT方法的专家。通过这项研究获得的技术和知识应有助于促进新的商业连续平板制造工艺的建设。具有商业代表性的开发设备也应定期运输到伯明翰大学的PEPT设施。这一强大的技术应用于对这些系统进行进一步分析，以帮助未来的开发活动。

Continuous processing offers many advantages over more traditional batch-wise unit operationssuch as: reduction in operating costs, increased agility as well as a reduced footprint on thefactory floor. Continuous Direct Compression (CDC) is one such process that seeks to convertraw input materials into tablets all as one continuous process.One of the key advantages of continuous manufacturing technologies is the way they may beintegrated together with Process Analytical Technology (PAT). PAT sensors can subsequently beused to gain rapid understanding of how a given tablet formulation responds to changes in theprocess parameters and therefore a robust operating range can be established. Furthermore,being able to monitor blend homogeneity in real time, using models constructed through PAT,can form a crucial part of the final quality control strategy.The successful candidate will become an expert in developing PAT methods for a continuoustableting process, through a combination of experimentation, data analysis and using artificialintelligence modelling techniques. The techniques and knowledge obtained through thisresearch shall be used to help facilitate the construction of new commercial continuous tabletmanufacturing processes.The commercially representative development equipment shall also be periodically transportedto the PEPT facility in the University of Birmingham. This powerful technique shall be used toperform further analysis of these systems to aid in future development activities.