Characterising and modelling a continuous tabletting line using Process Analytical Technology (PAT) and Positron Emission Particle Tracking (PEPT)

连续处理提供了许多优于传统分批单元操作的优点，例如：降低运营成本，提高灵活性以及减少工厂占地面积。连续直接压片（CDC）就是这样一种工艺，它旨在将原料转化为片剂，这是一个连续的过程。连续生产技术的关键优势之一是它们可以与过程分析技术（PAT）集成在一起。PAT传感器随后可用于快速了解给定片剂配方如何响应工艺参数的变化，因此可建立稳健的操作范围。此外，能够使用PAT构建的模型在真实的时间内监测混合均匀性，可以形成最终质量控制策略的关键部分。成功的候选人将成为开发PAT方法的专家，通过实验，数据分析和使用人工智能建模技术的组合，用于连续稳定的过程。通过本研究获得的技术和知识应用于帮助促进新的商业连续片剂生产工艺的构建。商业代表性开发设备也应定期运输到伯明翰大学的PEPT设施。这一强大的技术将被用于对这些系统进行进一步的分析，以帮助未来的开发活动。

Continuous processing offers many advantages over more traditional batch-wise unit operationssuch as: reduction in operating costs, increased agility as well as a reduced footprint on thefactory floor. Continuous Direct Compression (CDC) is one such process that seeks to convertraw input materials into tablets all as one continuous process.One of the key advantages of continuous manufacturing technologies is the way they may beintegrated together with Process Analytical Technology (PAT). PAT sensors can subsequently beused to gain rapid understanding of how a given tablet formulation responds to changes in theprocess parameters and therefore a robust operating range can be established. Furthermore,being able to monitor blend homogeneity in real time, using models constructed through PAT,can form a crucial part of the final quality control strategy.The successful candidate will become an expert in developing PAT methods for a continuoustableting process, through a combination of experimentation, data analysis and using artificialintelligence modelling techniques. The techniques and knowledge obtained through thisresearch shall be used to help facilitate the construction of new commercial continuous tabletmanufacturing processes.The commercially representative development equipment shall also be periodically transportedto the PEPT facility in the University of Birmingham. This powerful technique shall be used toperform further analysis of these systems to aid in future development activities.