Characterising and modelling a continuous tabletting line using Process Analytical Technology (PAT) and Positron Emission Particle Tracking (PEPT)

与传统的批量单元操作相比，连续处理提供了许多优势，例如：降低运营成本，提高灵活性以及减少工厂车间的占地面积。连续直接压缩（CDC）就是这样一种过程，它寻求将输入材料转换成片剂，所有这些都是一个连续的过程。连续制造技术的关键优势之一是它们可以与过程分析技术（PAT）集成在一起。PAT传感器随后可用于快速了解给定片剂配方对工艺参数变化的反应，因此可以建立稳健的操作范围。此外，能够使用PAT构建的模型实时监测混合均匀性，可以成为最终质量控制策略的关键部分。通过结合实验、数据分析和使用人工智能建模技术，成功的候选人将成为为持续稳定过程开发PAT方法的专家。通过本研究获得的技术和知识将有助于促进新的商业连续片剂制造工艺的建设。具有商业代表性的开发设备也应定期运送到伯明翰大学的PEPT设施。这项强大的技术有助于对这些系统进行进一步分析，以帮助未来的开发活动。

Continuous processing offers many advantages over more traditional batch-wise unit operationssuch as: reduction in operating costs, increased agility as well as a reduced footprint on thefactory floor. Continuous Direct Compression (CDC) is one such process that seeks to convertraw input materials into tablets all as one continuous process.One of the key advantages of continuous manufacturing technologies is the way they may beintegrated together with Process Analytical Technology (PAT). PAT sensors can subsequently beused to gain rapid understanding of how a given tablet formulation responds to changes in theprocess parameters and therefore a robust operating range can be established. Furthermore,being able to monitor blend homogeneity in real time, using models constructed through PAT,can form a crucial part of the final quality control strategy.The successful candidate will become an expert in developing PAT methods for a continuoustableting process, through a combination of experimentation, data analysis and using artificialintelligence modelling techniques. The techniques and knowledge obtained through thisresearch shall be used to help facilitate the construction of new commercial continuous tabletmanufacturing processes.The commercially representative development equipment shall also be periodically transportedto the PEPT facility in the University of Birmingham. This powerful technique shall be used toperform further analysis of these systems to aid in future development activities.