Academic Career Development in Botanical Dietary Supplements

植物膳食补充剂的学术职业发展

• 批准号: 7318080
• 负责人: Zaijie Jim Wang
• 金额: $ 13.52万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7318080
• 关键词: Adenylate Cyclase; Affect; Affinity; Agonist; American; Aminobutyric Acid; Aminobutyric Acids; Angelica sinensis; Antioxidants; Anxiety; Award; Binding; Biological Assay; Biological Factors; Botanicals; Cells; Chastetree; Cimicifuga racemosa; Country; Coupled; Cyclic AMP; DRD2 gene; DSM-IV; Data; Development; Dopamine; Dopamine D2 Receptor; Education; Educational Curriculum; Educational process of instructing; Exhibits; Female; G-Protein-Coupled Receptors; GABA-A Receptor; GTP-Binding Proteins; Goals; Gonadal Steroid Hormones; Grant; Health; Health Professional; Herb; Hot flushes; Illinois; Inhibitory Concentration 50; K-Series Research Career Programs; Leadership; Ligands; Literature; Measures; Mediator of activation protein; Medical; Menopausal Symptom; Menopausal hot flushes; Menopause; Mental Depression; Mission; Molecular; Mood Disorders; Neuraxis; Neurotransmitter Receptor; Numbers; Opiates; Outcome; Pathway interactions; Pharmaceutical Preparations; Pharmacognosy; Pharmacology; Physiological; Plant Extracts; Plants; Population; Premenstrual syndrome; Production; Protein Inhibition; Receptor Activation; Research; Research Proposals; Serotonin; Sleeplessness; Students; Symptoms; System; TNFRSF5 gene; Testing; Time; Training; Universities; Valeriana officinalis; Viburnum; Woman; Women' s Health; Work; base; career; dietary supplements; endogenous opioids; gamma-Aminobutyric Acid; high throughput screening; improved; novel; premenstrual dysphoric disorder; professor; programs; protein activation; receptor; research study; skills

DESCRIPTION (provided by applicant): The main objective of this Academic Career Development Award is to enable the candidate, Dr. Z. Jim Wang, to develop an academic career in botanical dietary supplements (BDS). The UIC/NIH Center for Botanical Dietary Supplements Research (ODS/NCCAM/ORWH grant P50 AT00155), under the leadership of Professor Norman R. Farnsworth, is already a leader in the research and information about the use of natural product supplements, particularly for women's health. Currently, the Center associated Pharmacognosy graduate program is undergoing substantial overhauls to revamp curricula to reflect the changing field. Dr. Wang will take on the tasks of developing curricula in natural products pharmacology. Dr. Wang will also teach in these courses. The new curricula in BDS will be offered to both graduate and health professional students, and will also be made available to health care professionals on the University of Illinois medical campus. The candidate will also develop pharmacological research programs for the studies of BDS, with an emphasis on CMS and receptor-based bioassays. Working closely with Dr. Farnsworth, Dr. Susan Goldman (Education Consultant), and other colleagues, the candidate will specifically achieve the following career development goals during the award period: 1) develop research programs in botanical dietary supplements; 2) develop curricula in natural products pharmacology; 3) improve teaching skills; 4) develop leadership skills. The specific research proposal will develop novel receptor-based bioassays, which will then be applied to study the molecular mechanisms of BDS used in women's health. The proposal takes advantage of the candidate's training background, while offering opportunities for career development including training in responsible conduct of research. The award is ideally suited for the candidate, as it will provide protected time and clear and achievable goals that will allow the candidate to become an academic leader, fulfilling the dual mission of education and research in the field of botanical dietary supplements.

描述（由申请人提供）：该学术职业发展奖的主要目标是使候选人 Z. Jim Wang 博士能够在植物膳食补充剂 (BDS) 领域发展学术生涯。 UIC/NIH 植物膳食补充剂研究中心（ODS/NCCAM/ORWH 授予 P50 AT00155）在 Norman R. Farnsworth 教授的领导下，已经成为天然产品补充剂使用研究和信息的领导者，特别是对于女性健康。目前，该中心相关的生药学研究生项目正在进行重大改革，以修改课程以反映不断变化的领域。王博士将承担天然产物药理学课程开发的任务。王博士也将教授这些课程。 BDS 的新课程将向研究生和卫生专业学生提供，也将向伊利诺伊大学医学院的卫生保健专业人员提供。该候选人还将开发 BDS 研究的药理学研究项目，重点是 CMS 和基于受体的生物测定。与Farnsworth博士、Susan Goldman博士（教育顾问）和其他同事密切合作，候选人将在获奖期间具体实现以下职业发展目标：1）开发植物膳食补充剂的研究项目； 2）开发天然产物药理学课程； 3）提高教学技能； 4）培养领导能力。具体的研究计划将开发新型基于受体的生物测定法，然后将其应用于研究 BDS 在女性健康中的分子机制。该提案利用了候选人的培训背景，同时提供职业发展机会，包括负责任的研究行为培训。该奖项非常适合候选人，因为它将提供受保护的时间和明确且可实现的目标，使候选人成为学术领袖，履行植物膳食补充剂领域教育和研究的双重使命。