Academic Career Development in Botanical Dietary Supplements

植物膳食补充剂的学术职业发展

• 批准号: 8127881
• 负责人: Zaijie Jim Wang
• 金额: $ 13.52万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8127881
• 关键词: Adenylate Cyclase; Affect; Affinity; Agonist; American Psychiatric Association; Aminobutyric Acids; Angelica sinensis; Antioxidants; Anxiety; Award; Binding; Biological Assay; Biological Factors; Botanicals; Cells; Chastetree; Cimicifuga racemosa; Country; Coupled; Cyclic AMP; DRD2 gene; DSM-IV; Data; Dopamine; Dopamine D2 Receptor; Education; Educational Curriculum; Educational process of instructing; Exhibits; Female; G-Protein-Coupled Receptors; GABA-A Receptor; GTP-Binding Proteins; Goals; Gonadal Steroid Hormones; Grant; Health; Health Professional; Herb; Hot flushes; Illinois; Inhibitory Concentration 50; K-Series Research Career Programs; Leadership; Ligands; Literature; Measures; Mediator of activation protein; Medical; Menopausal Symptom; Menopause; Mental Depression; Mission; Molecular; Mood Disorders; National Center for Complementary and Alternative Medicine; Neuraxis; Neurotransmitter Receptor; Opiates; Outcome; Pathway interactions; Pharmaceutical Preparations; Pharmacognosy; Pharmacology; Physiological; Plant Extracts; Plants; Population; Premenstrual syndrome; Production; Protein Inhibition; Receptor Activation; Research; Research Proposals; Serotonin; Sleeplessness; Students; Symptoms; System; TNFRSF5 gene; Testing; Time; Training; United States National Institutes of Health; Universities; Valeriana officinalis; Viburnum; Woman; Women' s Health; Work; base; career; career development; dietary supplements; endogenous opioids; gamma-Aminobutyric Acid; high throughput screening; improved; novel; premenstrual dysphoric disorder; professor; programs; protein activation; receptor; research study; responsible research conduct; skills

The main objective of this Academic Career Development Award is to enable the candidate, Dr. Z. Jim Wang, to develop an academic career in botanical dietary supplements (BDS). The UIC/NIH Center for Botanical Dietary Supplements Research (ODS/NCCAM/ORWH grant P50 AT00155), under the leadership of Professor Norman R. Farnsworth, is already a leader in the research and information about the use of natural product supplements, particularly for women's health. Currently, the Center associated Pharmacognosy graduate program is undergoing substantial overhauls to revamp curricula to reflect the changing field. Dr. Wang will take on the tasks of developing curricula in natural products pharmacology. Dr. Wang will also teach in these courses. The new curricula in BDS will be offered to both graduate and health professional students, and will also be made available to health care professionals on the University of Illinois medical campus. The candidate will also develop pharmacological research programs for the studies of BDS, with an emphasis on CMS and receptor-based bioassays. Working closely with Dr. Farnsworth, Dr. Susan Goldman (Education Consultant), and other colleagues, the candidate will specifically achieve the following career development goals during the award period: 1) develop research programs in botanical dietary supplements; 2) develop curricula in natural products pharmacology; 3) improve teaching skills; 4) develop leadership skills. The specific research proposal will develop novel receptor-based bioassays, which will then be applied to study the molecular mechanisms of BDS used in women's health. The proposal takes advantage of the candidate's training background, while offering opportunities for career development including training in responsible conduct of research. The award is ideally suited for the candidate, as it will provide protected time and clear and achievable goals that will allow the candidate to become an academic leader, fulfilling the dual mission of education and research in the field of botanical dietary supplements.

该学术职业发展奖的主要目标是使候选人 Z. Jim 博士能够 Wang，发展植物膳食补充剂（BDS）方面的学术生涯。 UIC/NIH 中心 植物膳食补充剂研究（ODS/NCCAM/ORWH 拨款 P50 AT00155），领导下 Norman R. Farnsworth 教授已经是有关使用的研究和信息方面的领导者 天然产品补充剂，特别是对女性健康而言。目前，中心相关 生药学研究生课程正在进行重大改革，以修改课程以反映 改变领域。王博士将承担天然产物药理学课程开发的任务。 王博士也将教授这些课程。 BDS 的新课程将提供给研究生和 健康专业的学生，​​也将提供给大学的医疗保健专业人员 伊利诺伊州医学院。候选人还将开发药理学研究计划 BDS 研究，重点是 CMS 和基于受体的生物测定。与博士密切合作。 Farnsworth、Susan Goldman 博士（教育顾问）和其他同事，候选人将具体 在奖励期间实现以下职业发展目标： 1）开发研究项目 植物膳食补充剂； 2）开发天然产物药理学课程； 3）改进教学 技能； 4）培养领导能力。具体的研究计划将开发基于受体的新型 生物测定，然后将其用于研究 BDS 用于妇女健康的分子机制。 该提案利用了候选人的培训背景，同时提供了职业机会 发展，包括负责任地进行研究的培训。该奖项非常适合 候选人，因为它将提供受保护的时间和明确且可实现的目标，使候选人能够 成为学术带头人，履行植物学领域教育和研究的双重使命 膳食补充剂。

项目成果

Ca2+/calmodulin-dependent protein kinase II alpha is required for the initiation and maintenance of opioid-induced hyperalgesia.

• DOI: 10.1523/jneurosci.4346-09.2010
• 发表时间: 2010-01-06
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Chen Y;Yang C;Wang ZJ
• 通讯作者: Wang ZJ

Orally administered nanocurcumin to attenuate morphine tolerance: comparison between negatively charged PLGA and partially and fully PEGylated nanoparticles.

口服纳米姜黄素可减弱吗啡耐受性：带负电荷的 PLGA 与部分和完全聚乙二醇化纳米颗粒之间的比较。

• DOI: 10.1021/mp400358z
• 发表时间: 2013
• 期刊: Molecular pharmaceutics
• 影响因子: 4.9
• 作者: Shen,Hao;Hu,Xiaoyu;Szymusiak,Magdalena;Wang,ZaijieJim;Liu,Ying
• 通讯作者: Liu,Ying

PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα.

PLGA-苏蛋白减弱阿片类药物诱导的痛觉过敏，并抑制脊髓CAMKIIα。

• DOI: 10.1371/journal.pone.0146393
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hu X;Huang F;Szymusiak M;Tian X;Liu Y;Wang ZJ
• 通讯作者: Wang ZJ