Sexual Differentiation of the Nervous System

神经系统的性别分化

• 批准号: 7175436
• 负责人: NANCY G FORGER
• 金额: $ 12.53万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-22 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7175436
• 关键词: Apoptosis; Apoptotic; Area; Award; Bax protein; Behavior; Biological; Biological Models; Brain; Cancer cell line; Categories; Cell Count; Cell Death; Cell Nucleus; Cell Survival; Cells; Cessation of life; Confocal Microscopy; Development; Educational process of instructing; Ensure; Equilibrium; Exhibits; Family; Family member; Female; Funding; Gene Deletion; Gene Family; Genes; Gonadal Steroid Hormones; Hormonal; Hormones; Human; Hypothalamic structure; In Situ Hybridization; Incidence; Independent Scientist Award; Knockout Mice; Life; Massachusetts; Mediating; Molecular; Motor Neurons; Mus; Muscle; Nervous system structure; Neuraxis; Neurons; Neurosciences; Neurosecretory Systems; Neurotransmitters; Numbers; Perinatal; Peripheral; Personal Satisfaction; Pharmaceutical Preparations; Phenotype; Predisposition; Protein Family; Proteins; Psychology; Range; Rate; Research; Sex Characteristics; Spinal; Spinal Cord; Structure of terminal stria nuclei of preoptic region; Study models; Techniques; Testing; Testosterone; Thinking; Time; Tissues; Training Support; Tyrosine 3-Monooxygenase; Universities; Vasopressins; Work; cell suicide; dimorphism; falls; immunocytochemistry; male; member; mutant; nervous system disorder; neurochemistry; neurotrophic factor; novel; professor; programs; relating to nervous system; success

DESCRIPTION (provided by applicant): A large number of sex differences have been described in the mammalian central nervous system. Such morphological dimorphisms may underlie well-documented sex differences in behavior, in susceptibility to certain drugs, and in the incidence of human neurological disorders. In many cases, neural sex differences have been shown to be due to gonadal steroid hormones acting early in development. However, the cellular and molecular mechanisms governed by hormones in the developing nervous system are not well understood. The long-range objective of this candidate for an Independent Scientist Award is to identify cellular and molecular mechanisms of sexual differentiation in the brain and spinal cord. Dr. Forger is a professor in the Psychology Department at the University of Massachusetts. She is a member of the Neuroscience and Behavior program and enjoys the support of a cohesive and very visible group of colleagues in the Center for Neuroendocrine Studies. The candidate will soon be directing several major research efforts. Her teaching load within the Psychology Department is substantial. The award will allow her time to intensively focus on funded projects, to interact more with trainees and colleagues, and to pursue new areas of research. In particular, this award will support training in confocal microscopy and molecular biological techniques. The research plan outlines strategies for investigating the mechanisms underlying hormonally controlled cell death in three well-studied model systems: the spinal nucleus of the bulbocavernosus, the anteroventral periventricular nucleus of the hypothalamus, and the bed nucleus of the stria terminalis. Mice will be used throughout, to take advantage of the power of genetically manipulated strains. An R01 proposal describing these studies was recently reviewed and received outstanding priority ratings. An Independent Scientist Award would ensure the success of this program.

描述（由申请人提供）：在哺乳动物中枢神经系统中描述了大量性别差异。这种形态上的二态性可能是行为、对某些药物的敏感性和人类神经系统疾病发生率方面的性别差异的基础。在许多情况下，神经性别差异已被证明是由于性腺类固醇激素在发育早期起作用。然而，激素在发育中的神经系统中控制的细胞和分子机制尚不清楚。 这位独立科学家奖候选人的长期目标是确定大脑和脊髓中性别分化的细胞和分子机制。Forger博士是马萨诸塞州大学心理学系的教授。她是神经科学和行为计划的成员，并享有在神经内分泌研究中心的一个有凝聚力和非常明显的同事群体的支持。这位候选人很快将指导几项重大的研究工作。她在心理学系的教学负担是巨大的。该奖项将使她有时间集中精力研究受资助的项目，与学员和同事进行更多互动，并探索新的研究领域。特别是，该奖项将支持共聚焦显微镜和分子生物学技术的培训。该研究计划概述了在三个研究充分的模型系统中研究神经控制细胞死亡的机制的策略：球海绵体肌的脊髓核，下丘脑的前腹侧室周核和终纹的床核。整个过程中将使用小鼠，以利用基因操作菌株的力量。描述这些研究的R01提案最近得到了审查，并获得了突出的优先评级。独立科学家奖将确保该计划的成功。