IMMEDIATE EARLY GENE REGULATED DEVELOPMENT/PLASTICITY

立即早期基因调控的发育/可塑性

• 批准号: 7194355
• 负责人: WARREN G TOURTELLOTTE
• 金额: $ 14.15万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7194355
• 关键词: A Mouse; Adult; Animal Model; Award; Axon; Binding; Cell Line; Cell physiology; Cells; Cessation of life; Clinical Services; Commit; Cyclic AMP-Responsive DNA-Binding Protein; Defect; Development; Development Plans; Doctor of Medicine; Doctor of Philosophy; Ear; Embryo; Family; Gene Expression Regulation; Gene Targeting; Genes; Genetic Transcription; Genome; Growth; Growth Factor; Human; Immediate-Early Genes; In Vitro; Independent Scientist Award; Institution; Laboratories; Mediating; Membrane; Methodology; Microarray Analysis; Mission; Mus; Nervous system structure; Neurites; Neuroblastoma; Neurology; Neurons; Neurosciences; Pathology; Pathway Analysis; Perinatal; Peripheral Nervous System; Pharmaceutical Preparations; Play; Radiation; Research; Resource Development; Role; Seizures; Signal Transduction; Signal Transduction Pathway; Stimulus; Sympathetic Ganglia; Sympathetic Nervous System; Synapses; Transcriptional Regulation; Universities; Wages; Zinc Fingers; career; chromatin immunoprecipitation; cytokine; extracellular; gene function; gene induction; improved; in vivo; insight; medical schools; member; nerve supply; nervous system development; neurotrophic factor; novel; professor; programs; research study; response; transcription factor

DESCRIPTION (provided by applicant): This is an Independent Scientist Award for Warren G. Tourtellotte, M.D., Ph.D. who is currently an Assistant Professor of Pathology, Neurology and Neuroscience at Northwestern University, Feinberg School of Medicine. Dr. Tourtellotte devotes greater than 75% professional effort to research focused on transcriptional regulation of genes involved in central and peripheral nervous system development. This Research Career Award will assure Dr. Tourtellotte stable salary support to allow him to commit 75% professional effort to research. The institution is supportive of a 75% research effort as evidenced by minimized clinical service commitments and recent expansion of the research space available to Dr. Tourtellotte. The career development plan will extend the focus of Egr transcription factor function in the laboratory to include studies of cellular physiology, signal transduction and genome wide regulatory network analysis. Dr. Tourtellotte will use the career development resources to strengthen collaborative networks both within the institution and externally to strengthen the research program by improving the methodology, scientific staff and expertise available to the laboratory. The Research Plan will characterize the role of Egr transcription factors in sympathetic nervous system development, neurotrophin mediated gene regulation and signal transduction. The planned career development activities will take full advantage of the rich collaborative and career development resources available at Northwestern University.

描述（由申请人提供）：这是一个独立的科学家奖沃伦G。Tourtelevision，医学博士，博士他目前是西北大学范伯格医学院病理学、神经病学和神经科学的助理教授。Tourtelevision博士将超过75%的专业精力投入到专注于中枢和外周神经系统发育相关基因转录调控的研究中。这个研究职业奖将保证博士Tourtelevision稳定的工资支持，让他承诺75%的专业努力的研究。该机构支持75%的研究工作，这一点可以从最小化的临床服务承诺和最近扩大的研究空间中得到证明。职业发展计划将扩大Egr转录因子功能在实验室的重点，包括细胞生理学，信号转导和全基因组调控网络分析的研究。tourtelevision将利用职业发展资源，加强机构内外的合作网络，通过改进实验室的方法，科学工作人员和专业知识来加强研究计划。该研究计划将描述Egr转录因子在交感神经系统发育，神经营养因子介导的基因调控和信号转导中的作用。计划中的职业发展活动将充分利用西北大学丰富的协作和职业发展资源。