Mentoring and Research in Mouse Pathobiology

应聘者描述(申请人提供)：该候选人是董事会认证的解剖病理学家和神经病理学家，在产生和研究转基因小鼠以模拟疾病发病机制和基本生物学机制方面具有丰富的经验。图尔特洛特博士的独立研究项目专注于神经发育和行为的早期基因调控，它是西北大学小鼠病理生物学研究的本科生、博士后和博士后的培训项目。具体地说，Tourtellotte博士的研究计划侧重于：(1)调节神经-肌肉相互作用的分子机制，(2)自主神经系统的发育和功能障碍，以及(3)IKBKAP基因在人类家族性自主神经功能障碍中的作用机制。图尔特洛特博士还担任临床病理学住院医师和研究员的导师，他们中的许多人都参与了利用小鼠病理生物学来模拟人类疾病机制的研究项目。图尔特洛特博士提议，通过帮助加强西北大学的小鼠病理生物学培训和研究基础设施，来扩大他的指导角色。通过他对西北大学转基因和靶向突变实验室和小鼠表型核心实验室的领导，他提议加强对希望为自己的独立研究项目使用和/或开发小鼠模型的初级和高级研究人员提供的小鼠病理生物学研究方面的培训和服务。Tourtellotte博士正在寻求职业发展支持，以使他能够减少临床服务承诺，将精力集中在小鼠病理生物学研究和培训上。具体地说，他将继续加强自己的自主研究和培训计划，并提升西北大学与小鼠病理生物学相关的核心实验室资源和培训计划。后一种努力将使他能够最大限度地发挥自己作为未来一代老鼠病理生物学家导师的影响力，而不仅仅是他目前在独立研究项目中指导的相对较少的受训人员。

DESCRIPTION (provided by applicant): The Candidate is a board certified Anatomic Pathologist and Neuropathologist with extensive experience in generating and studying genetically-modified mice to model disease pathogenesis and basic biological mechanisms. Dr. Tourtellotte's independent research program focuses on immediate early gene regulation in neurodevelopment and behavior, and it serves as a training program for undergraduate, predoctoral and postdoctoral students in mouse pathobiology research at Northwestern University. Specifically, Dr. Tourtellotte's research program focuses on: (1) molecular mechanisms mediating nerve-muscle interactions, (2) autonomic nervous system development and dysfunction and (3) the mechanisms of IKBKAP gene function in human familial dysautonomia. Dr. Tourtellotte also serves as a mentor to clinical pathology residents and fellows, many of whom are engaged in research projects that use murine pathobiology to model mechanisms of human disease. Dr. Tourtellotte is proposing to expand his mentoring role by helping to enhance the mouse pathobiology training and research infrastructure at Northwestern University. Through his leadership of the Transgenic and Targeted Mutagenesis Laboratory and the Mouse Phenotyping Core Laboratory at Northwestern University, he is proposing to enhance the training and service in mouse pathobiology research that is available to both junior and senior investigators who wish to use and/or develop mouse models for their own independent research programs. Dr. Tourtellotte is seeking career development support to enable him to decrease his clinical service commitment and focus his efforts on mouse pathobiology research and training. Specifically, he will continue to strengthen his independent research and training program and enhance mouse pathobiology related core laboratory resources and training programs at Northwestern University. The latter efforts will enable him to maximize his influence as a mentor to a future generation of mouse pathobiologists beyond the relatively small number of trainees he currently mentors in his independent research program.