Translation of a rapid integrated tendon repair system

手部肌腱损伤的发病率为每年28/10万。屈肌腱损伤约占手部肌腱损伤的40%，许多患者伴有多发性肌腱损伤。屈肌腱损伤主要影响劳动年龄的年轻男性，涉及体力劳动。手部肌腱损伤可能会严重致残，这需要12周的康复时间。平均而言，一次屈肌腱修复的费用为1330 GB，与此相关的因缺勤而导致的康复和社会成本估计约为15,000 GB。其中一些肌腱尤其难以修复，因为肌肉收缩，导致切断的肌腱末端进一步收缩到宿主组织中。目前，在不损伤周围结构的情况下取回断裂的近端肌腱是非常困难的，这往往会导致粘连形成，从而限制功能结果。肌腱损伤主要通过缝合修复；肌腱修复技术进展有限。已有研究表明，缝合修复会导致肌腱组织上的高应力区，从而导致细胞死亡和瘢痕形成。屈肌腱修复仍然是一个未得到满足的需求，因为只有75%的修复达到了令人满意的功能效果，再手术率为11%。

The incidence rate of hand tendon injuries is 28 per 100,000 per annum. Flexor tendon injuries account for ~40% hand tendon injuries and many patients suffer from multiple tendon injuries. Flexor tendon injuries predominantly affect working-aged young males involving manual labour. Hand tendon injuries can be severely disabling, which requires a rehabilitation time of 12 weeks. On average, a single flexor tendon repair costs £1330, and its associated rehabilitation and societal costs due to absence from work are estimated to be around £15,000. Some of these tendons in particular are very challenging to repair due to muscle contraction, which leads to the severed tendon end retracting further into the host tissue. At present, retrieving the severed proximal tendon is very difficult without damaging the surrounding structures, which often leads to adhesion formation and thus limited functional outcome. Tendon injuries are predominantly repaired with sutures; and there has been limited progress in tendon repair techniques. It has been shown that suture repairs lead to high stress areas on tendon tissue which cause cell death and scar formation. Flexor tendon repair remains an unmet need as only 75% repairs achieve a satisfactory functional result with an 11% reoperation rate.