Integrated bioreactor platform for rapid scale-up and translation

用于快速放大和转化的集成生物反应器平台

• 批准号: BB/W019779/1
• 负责人: James Winterburn
• 金额: $ 70.55万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FW019779%2F1
• 关键词: Integrated; bioreactor; platform; rapid; scale

In order to meet the UK Government's sustainability and clean growth targets there is a clear need for a switch from crude oil derived petrochemicals to biobased alternatives produced from renewable resources. To address this sustainable biomanufacturing routes are urgently required to remove the dependence of chemicals production on fossil fuel derived raw materials. This goal is central to the UKRI National Engineering Biology Programme theme of Clean Growth and the genesis of a Circular Economy and reduction of Greenhouse Gas (GHG) emissions, all of which are enshrined in Net Zero/Clean Growth targets in the UK Government's Industrial Strategy. This transition from a reliance on petrochemicals to sustainable biomanufacturing presents major challenges across Technology Readiness Levels (TRLs). Industrial transition to a Clean and Circular Bioeconomy is linked to innovations at low TRL, the proposed bioreactor platform will facilitate the transition to higher TRLs, providing a key step to pull through academic discovery to process verification. The new platform will build on major strategic UK government investments in UoM hosted Centres of Excellence, and further support Manchester as the UK epicentre for sustainable chemicals manufacturing, leveraging excellence in biocatalysis and synthetic biology, and combining this with biochemical engineering and fermentation process development expertise for successful scale up and industrial translation.The requested integrated bioreactor platform will fill a recognised gap in the UK's process development and scale up capability and will support the engineering development of scalable processes for technically feasible and economically viable biobased chemicals production. To achieve this the bioreactor platform will provide capability spanning small-scale parallel fermentation for quick screening and lab benchtop bioprocess development to scale up and process design and optimisation. The advances in research translation and the increase in commercialisation opportunities enabled by the bioreactor platform will facilitate the switch from fossil to bio-based chemicals, providing a renewable route to the products used in daily life.

为了满足英国政府的可持续性和清洁增长目标，很明显地需要从原油衍生的石化物转换为可再生资源产生的生物基替代品。迫切需要解决这种可持续的生物制造路线，以消除化学生产对化石燃料衍生的原材料的依赖性。这一目标是乌克里国家工程生物学计划的核心，其清洁生长的主题以及循环经济的起源和减少温室气体（GHG）排放的核心，所有这些排放量都是英国政府工业战略中的净零/清洁增长目标。从依赖石油化学物质到可持续生物制造的这种过渡提出了技术准备水平（TRL）的主要挑战。工业过渡到干净和循环的生物经济与低TRL的创新有关，拟议的生物反应器平台将促进向更高TRL的过渡，从而提供了一个关键步骤，以贯彻学习学术发现以进行过程验证。这个新平台将以英国对UOM的主要战略投资为基础，并在UOM上托管了卓越中心，并进一步支持曼彻斯特作为可持续化学品制造业的英国e Ecenter，在生物催化和合成生物学方面利用了卓越的卓越性，并将其与生物化学工程和发酵工程的开发相结合。扩展能力，并将支持可扩展过程的工程开发，以实现技术可行且经济可行的生物基化学物质生产。为了实现这一目标，生物反应器平台将提供跨越小规模并行发酵的能力，以快速筛选和实验室台式生物处理开发，以扩展和过程设计和优化。生物反应器平台实现的研究翻译的进步以及商业化机会的增加将有助于从化石转向基于生物的化学物质，从而为日常生活中使用的产品提供了可再生的途径。