Integrated bioreactor platform for rapid scale-up and translation

用于快速放大和转化的集成生物反应器平台

• 批准号: BB/W019779/1
• 负责人: James Winterburn
• 金额: $ 70.55万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FW019779%2F1
• 关键词: Integrated; bioreactor; platform; rapid; scale

In order to meet the UK Government's sustainability and clean growth targets there is a clear need for a switch from crude oil derived petrochemicals to biobased alternatives produced from renewable resources. To address this sustainable biomanufacturing routes are urgently required to remove the dependence of chemicals production on fossil fuel derived raw materials. This goal is central to the UKRI National Engineering Biology Programme theme of Clean Growth and the genesis of a Circular Economy and reduction of Greenhouse Gas (GHG) emissions, all of which are enshrined in Net Zero/Clean Growth targets in the UK Government's Industrial Strategy. This transition from a reliance on petrochemicals to sustainable biomanufacturing presents major challenges across Technology Readiness Levels (TRLs). Industrial transition to a Clean and Circular Bioeconomy is linked to innovations at low TRL, the proposed bioreactor platform will facilitate the transition to higher TRLs, providing a key step to pull through academic discovery to process verification. The new platform will build on major strategic UK government investments in UoM hosted Centres of Excellence, and further support Manchester as the UK epicentre for sustainable chemicals manufacturing, leveraging excellence in biocatalysis and synthetic biology, and combining this with biochemical engineering and fermentation process development expertise for successful scale up and industrial translation.The requested integrated bioreactor platform will fill a recognised gap in the UK's process development and scale up capability and will support the engineering development of scalable processes for technically feasible and economically viable biobased chemicals production. To achieve this the bioreactor platform will provide capability spanning small-scale parallel fermentation for quick screening and lab benchtop bioprocess development to scale up and process design and optimisation. The advances in research translation and the increase in commercialisation opportunities enabled by the bioreactor platform will facilitate the switch from fossil to bio-based chemicals, providing a renewable route to the products used in daily life.

为了实现英国政府的可持续发展和清洁增长目标，显然需要从原油衍生的石化产品转向由可再生资源生产的生物基替代品。为了解决这一问题，迫切需要可持续的生物制造路线，以消除化学品生产对化石燃料衍生原材料的依赖。这一目标是UKRI国家工程生物学计划主题清洁增长和循环经济的起源以及减少温室气体（GHG）排放的核心，所有这些都体现在英国政府工业战略的净零/清洁增长目标中。从依赖石化产品到可持续生物制造的转变对技术准备水平（TRL）提出了重大挑战。工业向清洁和循环生物经济的过渡与低TRL的创新有关，拟议的生物反应器平台将促进向更高TRL的过渡，为学术发现到工艺验证提供关键一步。新平台将建立在英国政府对密歇根大学卓越中心的重大战略投资基础上，并进一步支持曼彻斯特作为英国可持续化学品制造的中心，利用生物催化和合成生物学的卓越性，并将其与生物化学工程和发酵工艺开发专业知识相结合，以成功扩大规模和工业转化。所要求的集成生物反应器平台将填补英国的工艺开发和规模扩大能力，并将支持可扩展工艺的工程开发，以实现技术上可行和经济上可行的生物基化学品生产。为了实现这一目标，生物反应器平台将提供跨越小规模平行发酵的能力，用于快速筛选和实验室台式生物工艺开发，以扩大规模，并进行工艺设计和优化。生物反应器平台在研究转化方面的进步和商业化机会的增加将促进从化石化学品到生物基化学品的转变，为日常生活中使用的产品提供可再生途径。