Upgrades for the University of Michigan Center for Structural Biology

描述（由申请人提供）：密歇根大学结构生物学中心支持两个x射线设备，总共包括两个Rigaku旋转阳极，每个设备配备R-Axis IV成像板探测器，一个额外配备Bruker Smart2000 CCD相机。但是，这些系统的聚焦光学系统已经过时，并且一系列其他组件需要升级，以便为大量主要用户、他们的当地合作者和中心的一般用户提供大大增强的服务。本提案的主要目标是提供增强且可持续的仪器，这将极大地改善现场数据收集，不仅用于更常规的晶体学问题，而且还使我们能够使用和筛选小的，非理想的晶体，用于我们实验室正在研究的日益复杂和大型的蛋白质组装。

DESCRIPTION (provided by applicant): The Center for Structural Biology at the University of Michigan supports two X-ray facilities, consisting in total of two Rigaku rotating anodes, each equipped with a R-Axis IV imaging plate detector and one with an additional Bruker Smart2000 CCD camera. However, the focusing optics for these systems are antiquated, and a series of other components are in need of upgrades to provide greatly enhanced service to the large number of major users, their local collaborators and the general users of the Center. The major goal of this proposal is to provide enhanced yet sustainable instrumentation that will greatly improve data collection on site for not only more routine crystallographic problems, but also enable us to work with and screen small, non-ideal crystals being produced for the increasingly complex and large protein assemblies being investigated by our labs.