Upgrades for the University of Michigan Center for Structural Biology

密歇根大学结构生物学中心升级

• 批准号: 7389776
• 负责人: JEANNE A STUCKEY
• 金额: $ 31.2万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2008-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7389776
• 关键词: Anodes; Complex; Data Collection; Goals; Image; Michigan; Numbers; Optics; Proteins; Roentgen Rays; Series; Services; Site; System; Universities; Work; charge coupled device camera; detector; improved; instrumentation; structural biology

DESCRIPTION (provided by applicant): The Center for Structural Biology at the University of Michigan supports two X-ray facilities, consisting in total of two Rigaku rotating anodes, each equipped with a R-Axis IV imaging plate detector and one with an additional Bruker Smart2000 CCD camera. However, the focusing optics for these systems are antiquated, and a series of other components are in need of upgrades to provide greatly enhanced service to the large number of major users, their local collaborators and the general users of the Center. The major goal of this proposal is to provide enhanced yet sustainable instrumentation that will greatly improve data collection on site for not only more routine crystallographic problems, but also enable us to work with and screen small, non-ideal crystals being produced for the increasingly complex and large protein assemblies being investigated by our labs.

描述（由申请人提供）：密歇根大学结构生物学中心支持两个X射线设备，总共由两个理学旋转阳极组成，每个配有R-Axis IV成像板探测器，一个配有额外的Bruker Smart 2000 CCD相机。然而，这些系统的聚焦光学系统已经过时，一系列其他部件需要升级，以便为中心的大量主要用户、当地合作者和一般用户提供更好的服务。该提案的主要目标是提供增强但可持续的仪器，这将大大改善现场的数据收集，不仅用于更常规的晶体学问题，而且还使我们能够使用和筛选为我们实验室正在研究的日益复杂和大型的蛋白质组装而生产的小的非理想晶体。