HUMAN FACTOR VIIA & SOLUBLE TISSUE FACTOR & BX1 COMPLEX DATA COLLECTION

人为因素VIIA

• 批准号: 6586744
• 负责人: Marc David Whitlow
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586744
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; proteins; radiography; structural biology

Antigen recognition of T lymphocytes is mediated by highly diverse cell surface glycoproteins known as T cell receptors (TCRs). TCRs interact with a class of molecules known as superantigens (SAGs) which stimulate T cells. Superantigens, which may be of viral or bacterial origin, can induce profound immunological responses in the host such as toxic shock. However, no structural information is available on the interaction of SAGs with TCRs.

T淋巴细胞的抗原识别是由高度多样的 细胞表面糖蛋白，称为T细胞受体（TCR）。 的tcr 与一类称为超抗原（SAG）的分子相互作用， 刺激T细胞。 超抗原，其可以是病毒或细菌的 起源，可以在宿主中诱导深刻的免疫应答， 中毒性休克 然而，没有结构信息， SAG与TCR的相互作用。