Small Animal Positron Emission Tomography for Translational Research

用于转化研究的小动物正电子发射断层扫描

• 批准号: 7389787
• 负责人: RAO P GULLAPALLI
• 金额: $ 50万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2010-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7389787
• 关键词: Animal Disease Models; Animals; Area; Baltimore; Basic Science; Biodistribution; Collaborations; Count; Diagnostic Imaging; Disease Progression; Funding; Future; Housing; Human; Image; Image Analysis; Institution; Invasive; Laboratory Research; Magnetic Resonance Imaging; Maintenance; Maryland; Medical; Modality; Multimodal Imaging; Nature; Neurosciences; Occupational activity of managing finances; PET/CT scan; Performance; Pharmacology; Positron-Emission Tomography; Radiology Specialty; Rate; Research; Research Design; Research Personnel; Resolution; Resource Sharing; Resources; Role; System; Technology; Time; Training; Translating; Translational Research; Universities; attenuation; clinical application; experience; instrument; molecular imaging; oncology; transmission process

DESCRIPTION (provided by applicant): Fourteen investigators with 14 RO1 projects, 2 UO1 and one PO1 projects from the University of Maryland, Baltimore are requesting funds for the acquisition of a small animal PET/CT to advance their research in the areas of oncology, neuroscience and pharmacology. Small animal PET/CT provides unique opportunities for the study of animal models of disease and is a key component towards our aim of translating research from the laboratory to clinical application. The non-invasive, three- dimensional nature of the combined modality allows whole-animal biodistribution studies to be performed over an extended period of time in the same animal. Furthermore, the quantitative nature of PET/CT allows for powerful disease progression studies. These advantages will be exploited by our current and future NIH-funded investigators who will gain access to this technology as a shared resource. The proposed scanner will be housed in a dedicated animal imaging facility which currently accommodates a 7 Tesla animal MRI scanner. Much of the logistical support for the new scanner is already in place in the animal imaging facility and the addition of PET/CT is expected to compliment the high resolution anatomical images obtained from MRI. The Inveon MultiModality system from Siemens Molecular Imaging division has been selected for this project. This system is chosen because of its versatility to operate as independent single units or as a combined unit. The PET aspect of this unit provides high spatial resolution, sensitivity and count rate performance and has transmission imaging capability. The CT aspect of this instrument will provide high resolution anatomical images at a large field of view and will allow for PET attenuation and scatter correction. Researchers will be able to draw upon the considerable experience within the Radiology department in the field of diagnostic imaging, in particular imaging study design and quantitative image analysis. Administrative oversight of the scanner will be handled by a committee which will oversee financial management, staffing, instrument maintenance, training of researchers and scanner availability. Recognizing the growing role of molecular imaging and translational research the institution has made substantial commitment to the acquisition of the PET/CT system. The proposed animal PET/CT scanner is a much-needed resource which will benefit current researchers and will also stimulate future collaborations between different groups within and beyond the University of Maryland Medical System. The proposed small-animal PET/CT scanner will aid researchers in understanding animal models of disease and the efficacy of potential treatments. In this way the animal scanner will help translate the findings of basic science research to applications in humans.

描述（由申请人提供）：来自马里兰州大学（巴尔的摩）的14名研究者（14个RO 1项目、2个UO 1项目和1个PO 1项目）正在申请资金，用于购买小动物PET/CT，以推进其在肿瘤学、神经科学和药理学领域的研究。小动物PET/CT为疾病动物模型的研究提供了独特的机会，是我们将研究从实验室转化为临床应用的目标的关键组成部分。该组合模式的非侵入性三维性质允许在同一动物中长时间进行全动物生物分布研究。此外，PET/CT的定量性质允许进行强大的疾病进展研究。这些优势将被我们目前和未来的NIH资助的研究人员利用，他们将获得这项技术作为共享资源。申报扫描仪将放置在专用动物成像机构中，该机构目前可容纳7特斯拉动物MRI扫描仪。新扫描仪的大部分后勤支持已经在动物成像设施中到位，预计PET/CT的增加将补充从MRI获得的高分辨率解剖图像。本项目选择了Siemens Molecular Imaging部门的Inveon MultiModality系统。选择该系统是因为其作为独立的单个单元或作为组合单元操作的多功能性。该装置的PET方面提供高空间分辨率、灵敏度和计数率性能，并具有透射成像能力。该仪器的CT方面将在大视野下提供高分辨率解剖图像，并允许PET衰减和散射校正。研究人员将能够利用放射科在诊断成像领域的丰富经验，特别是成像研究设计和定量图像分析。扫描仪的行政监督将由一个委员会负责，该委员会将监督财务管理、人员配备、仪器维护、研究人员培训和扫描仪的供应情况。认识到分子成像和转化研究日益增长的作用，该机构已对收购PET/CT系统做出了实质性承诺。拟议的动物PET/CT扫描仪是一个急需的资源，这将有利于目前的研究人员，也将刺激未来的合作之间的不同群体内外的马里兰州医疗系统。 拟议中的小动物PET/CT扫描仪将帮助研究人员了解疾病的动物模型和潜在治疗方法的有效性。通过这种方式，动物扫描仪将有助于将基础科学研究的发现转化为人类的应用。