Imaging Shared Service

影像共享服务

• 批准号: 10267055
• 负责人: RAO P GULLAPALLI
• 金额: --
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-08 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267055
• 关键词: Advisory Services; Animals; Baltimore; Bioluminescence; Biomedical Engineering; Biometry; Blood; Blood - brain barrier anatomy; Cancer Center; Cancer Grant Supplements (P30); Cell Nucleus; Cerebrovascular Circulation; Cerebrum; Clinical; Clinical Oncology; Clinical Research; Clinical Trials; Comprehensive Cancer Center; Consult; Consultations; Data Analyses; Data Collection; Development; Discipline of Nuclear Medicine; Doctor of Philosophy; Drug Delivery Systems; Electron Microscopy; Electrons; Equipment; Experimental Designs; Faculty; Flow Cytometry; Fluorescence; Focused Ultrasound; Functional Imaging; Funding; Genomics; Grant; Health Services Accessibility; Human; Image; Image Analysis; Imaging technology; Immunoelectron Microscopy; Institutes; Institution; Intellectual Property; Interdisciplinary Study; Interventional Ultrasonography; Investigational Therapies; Journals; Knowledge; Laboratories; Liquid substance; Magnetic Resonance Imaging; Malignant Neoplasms; Maryland; Medicine; Mission; Molecular Biology; Nature; New England; Nuclear; Oncology; PET/CT scan; Pathology; Pathway interactions; Peer Review; Population Sciences; Positron-Emission Tomography; Publications; Publishing; Radiology Specialty; Reagent; Research; Research Design; Research Personnel; Resources; Sampling; Scanning Electron Microscopy; Services; Strategic Planning; Structure; Students; Technology; Therapeutic; Tissues; Training; Translating; Translational Research; Universities; Work; acronyms; anticancer research; biobank; biomarker discovery; cellular imaging; clinical investigation; clinical practice; clinical translation; college; confocal imaging; design; experimental study; hormone related cancer; human imaging; image guided; image guided intervention; imaging biomarker; imaging modality; instrument; live cell imaging; medical schools; member; metabolic abnormality assessment; microPET; multidisciplinary; neoplasm immunotherapy; neurosurgery; novel; novel imaging technology; pre-clinical; programs; quantitative imaging; structural biology; success; tool; translational pipeline; transmission process; tumor immunology; whole animal imaging

18.0 Abstract: Imaging Shared Service The Imaging Shared Service (ISS) provides UMGCCC members with a wide array of state-of-the-art imaging services, including structural and functional imaging of cells and imaging of whole animals and humans. ISS assists with experimental design, data analysis, data interpretation, and training to leverage advanced imaging services, accelerate discovery, and develop a robust translational pipeline. ISS resources include state-of-the- art confocal imaging for live cells, fixed tissues, ex vivo samples, and whole animals. ISS electron microscopy service provides transmission electron and scanning electron microscopy (conventional and cryo-samples), and immuno-electron microscopy to meet the needs of UMGCCC investigators. Whole-animal imaging is facilitated by a vast array of instruments, including whole-animal bioluminescence and fluorescence, micro-PET/CT, small- animal MRI for preclinical work, high-field MRI, combined PET/MRI, and CT services to meet the needs of investigators. ISS also provides unique technologies, such as dynamic nuclear hyperpolarization using C-13 and other nuclei, to study metabolic flux in cancer and MR-guided focused ultrasound for interventions that permit drug delivery across the blood–brain barrier. ISS offers an important platform for clinical translation that facilitates clinical trials. Given the multidisciplinary nature of ISS, its leaders and members interact extensively with other shared services and with investigators in all UMGCCC programs. ISS also provides educational opportunities and onsite training to facilitate the design, execution, and analysis of a wide variety of experiments. Staff members of ISS, some of whom are supported by the P30 grant, are experts who help users to define and refine study designs, assess research needs, and provide guidance. ISS advisory sessions often include consults from members of the Biostatistics Shared Service. ISS is committed to providing value-added state-of-the-art services to educate faculty, staff, fellows, and students and to offering advanced imaging technology to UMGCCC investigators. ISS provides streamlined access to services that prioritizes UMGCCC members with peer- reviewed funding. An internal Faculty Oversight Committee, consisting of ISS users, provides advice on core management of ISS and helps to develop strategic planning for new ISS equipment. ISS has very high utilization. In 2019, ISS supported studies by 88 investigators, 58 (65.9%) of whom were affiliated with UMGCCC. ISS users represent all UMGCCC research programs. In 2019, ISS supported $32.8 million of total funding. $17 million this funding was cancer-related and peer reviewed. ISS supported 239 cancer-related publications from 2015 to 2019 including those published in such high-impact journals as Radiology, Journal of Cerebral Blood.

18.0翻译后摘要：成像共享服务 影像共享服务（ISS）为UMGCCC成员提供各种最先进的影像 服务，包括细胞的结构和功能成像以及整个动物和人类的成像。ISS 协助实验设计、数据分析、数据解释和培训，以利用先进的成像技术 服务，加速发现，并开发一个强大的翻译管道。国际空间站的资源包括： 用于活细胞、固定组织、离体样品和整个动物的ART共焦成像。ISS电子显微镜 服务提供透射电子显微镜和扫描电子显微镜（常规和低温样品）， 免疫电子显微镜，以满足UMGCCC研究人员的需求。整个动物成像是便利的 通过大量的仪器，包括全动物生物发光和荧光，微型PET/CT，小， 用于临床前工作的动物MRI、高场MRI、组合PET/MRI和CT服务，以满足 investigators.国际空间站还提供独特的技术，例如使用C-13的动态核超极化， 其他核，研究癌症中的代谢通量和MR引导的聚焦超声干预， 通过血脑屏障的药物输送。ISS为临床翻译提供了一个重要平台， 临床试验鉴于国际空间站的多学科性质，其领导人和成员与其他组织广泛互动， 共享服务，并与所有UMGCCC项目的研究人员。ISS还提供教育机会 和现场培训，以促进各种实验的设计，执行和分析。工作人员 国际空间站的成员是帮助用户定义和完善 研究设计，评估研究需求，并提供指导。国际空间站咨询会议通常包括来自 生物统计学共享服务的成员。ISS致力于提供最先进的增值服务 教育教职员工、研究员和学生，并为UMGCCC提供先进的成像技术 investigators. ISS提供简化的服务访问，优先考虑UMGCCC成员与同行， 审查资金。一个由国际空间站用户组成的内部学院监督委员会， 国际空间站的管理，并帮助制定新的国际空间站设备的战略规划。ISS的利用率非常高。 2019年，ISS支持了88名研究者的研究，其中58名（65.9%）隶属于UMGCCC。ISS 用户代表所有UMGCCC研究计划。2019年，ISS支持了3280万美元的总资金。十七块 这笔资金与癌症有关，并经过同行审查。ISS支持了239份与癌症相关的出版物， 2015年至2019年，包括在放射学，脑血杂志等高影响力期刊上发表的论文。