An Open-access 800 MHz NMR Spectrometer for Central New England
新英格兰中部开放式 800 MHz NMR 波谱仪
基本信息
- 批准号:7125733
- 负责人:
- 金额:$ 200万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-05-01 至 2011-04-30
- 项目状态:已结题
- 来源:
- 关键词:Adrenergic ReceptorAdvisory CommitteesAntibiotic ResistanceAreaArtsBiochemistryBiologicalBostonCapital FinancingCell divisionChargeChemicalsCollaborationsCommitComplementComplexConditionConnecticutCrystallographyDNADNA DamageDataDatabasesDepositionDiseaseDistantDrug InteractionsDynein ATPaseEnzymesEquilibriumExhibitsFacility Construction Funding CategoryFigs - dietaryFundingHealthHousingInformation TechnologyInstitutionInvestigationJournalsLaboratoriesMagnetic ResonanceMassachusettsMediationMethodsMolecularMolecular BiologyMolecular ChaperonesMolecular MotorsNatureNeuritesNew EnglandNew YorkNuclearObject AttachmentOperative Surgical ProceduresParticipantPeptide Initiation FactorsProteinsPublicationsPublishingRateReceptor CellRelaxationResearchResearch PersonnelResolutionResourcesScheduleSignal TransductionSignaling ProteinSiteSolutionsStructureSystemTechnologyTimeTravelTumor Suppressor ProteinsUnited States National Institutes of HealthUniversitiesWagesWashingtonbasechemical reactioncollegecytokineexperienceimprovedinstrumentinstrumentationmacromoleculemolecular dynamicsmutantprotein foldingprotein functionprotein structureprotein structure functionreceptorrepairedresearch studystructural biologysuccesstool
项目摘要
DESCRIPTION (provided by applicant): Support for the acquisition of a state-of-the-art open-access 800 MHz NMR spectrometer for researchers in central New England is requested. The instrument will be located at the University of Connecticut Health Center in Farmington, CT, in the Gregory P. Mullen NMR Structural Biology Facility, which currently houses spectrometers operating at 400, 500, and 600 MHz. The Facility is operated by a full-time manager supported by the University of Connecticut. The 800 will be utilized by a core group of experienced investigators from the Storrs and Farmington UConn campuses, the University of Massachusetts (Amherst), Connecticut College, Dartmouth College, and Wesleyan and Yale Universities, and will be available to others. Participating investigators will obtain access on a priority basis, determined by a multi-institution scheduling committee. The founding group of investigators comprises 17 laboratories, 12 of which use NMR as a primary research tool, and has demonstrated outstanding NMR-based research into protein structure, function, and folding through its record of publication and external funding. The 800 will complement the existing resources available to these researchers and will enable the investigation of larger, more complex systems through its improved resolution and sensitivity. Gains in resolution will result both from the increased dispersion of nuclear resonances and from near-optimal TROSY effects. For partially folded states or complexes exhibiting chemical exchange, the higher field will improve resolution between states that show intermediate exchange at lower field. The 800 will facilitate field-dependent studies of relaxation used to probe molecular dynamics, and will provide preliminary data prior to experiments at higher field conducted at the national NMR resources. Studies to be supported by the 800 include proteins that participate in repair and replication at the sites of DNA damage, proteins that protect from DNA damage, protein folding intermediates, molecular chaperones, proteins that function as tumor suppressors and their mutants, dynein molecular motor proteins, proteins that function in cell division, the 2 adrenergic receptor, cell signaling proteins, enzymes involved in antibiotic resistance, hemopoeitic cytokines and their receptors, and multi- domain neurite outgrowth initiation factors.
描述(由申请人提供):请求支持为新英格兰中部的研究人员购置最先进的开放式800 MHz NMR光谱仪。该仪器将位于康涅狄格州法明顿的康涅狄格大学健康中心的Gregory P.马伦NMR结构生物学设施内,该设施目前拥有400、500和600 MHz的光谱仪。该设施由康涅狄格大学支持的全职经理运营。这800人将由来自斯托尔斯和法明顿康州大学校园、马萨诸塞州大学(阿默斯特)、康涅狄格学院、达特茅斯学院、卫斯理大学和耶鲁大学的经验丰富的调查人员组成的核心小组使用,并将提供给其他人。参与的研究者将根据多机构调度委员会确定的优先顺序获得访问权限。该研究小组由17个实验室组成,其中12个实验室使用NMR作为主要研究工具,并通过其出版记录和外部资金证明了对蛋白质结构,功能和折叠的杰出NMR研究。800将补充这些研究人员可用的现有资源,并将通过其改进的分辨率和灵敏度来研究更大,更复杂的系统。分辨率的提高将来自于核共振色散的增加和接近最佳的TROSY效应。对于部分折叠状态或表现出化学交换的复合物,较高的场将提高在较低场下表现出中间交换的状态之间的分辨率。800将促进用于探测分子动力学的弛豫场相关研究,并将在国家NMR资源进行的更高场实验之前提供初步数据。由800所支持的研究包括参与DNA损伤位点修复和复制的蛋白质,保护免受DNA损伤的蛋白质,蛋白质折叠中间体,分子伴侣,作为肿瘤抑制剂及其突变体的蛋白质,动力蛋白分子马达蛋白,在细胞分裂中起作用的蛋白质,2肾上腺素能受体,细胞信号蛋白,参与抗生素耐药性的酶,造血细胞因子及其受体和多结构域神经突生长起始因子。
项目成果
期刊论文数量(0)
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JEFFREY C HOCH其他文献
JEFFREY C HOCH的其他文献
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{{ truncateString('JEFFREY C HOCH', 18)}}的其他基金
Center for Biomolecular NMR Data Processing and Analysis
生物分子核磁共振数据处理与分析中心
- 批准号:
10581846 - 财政年份:2015
- 资助金额:
$ 200万 - 项目类别:
Center for Biomolecular NMR Data Processing and Analysis
生物分子核磁共振数据处理与分析中心
- 批准号:
10652459 - 财政年份:2015
- 资助金额:
$ 200万 - 项目类别:
NMRbox information management: CONNJUR and BMRB integration
NMRbox 信息管理:CONNJUR 和 BMRB 集成
- 批准号:
10652470 - 财政年份:2015
- 资助金额:
$ 200万 - 项目类别:
Center for Biomolecular NMR Data Processing and Analysis
生物分子核磁共振数据处理与分析中心
- 批准号:
10399323 - 财政年份:2015
- 资助金额:
$ 200万 - 项目类别:
Center for Biomolecular NMR Data Processing and Analysis
生物分子核磁共振数据处理与分析中心
- 批准号:
10797119 - 财政年份:2015
- 资助金额:
$ 200万 - 项目类别:
Center for Biomolecular NMR Data Processing and Analysis
生物分子核磁共振数据处理与分析中心
- 批准号:
10406890 - 财政年份:2015
- 资助金额:
$ 200万 - 项目类别:
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