Vevo 770 for Ultrasound Biomicroscopy

描述（由申请人提供）：最近能够定制具有特定基因突变的小鼠，这产生了一场新的生物医学革命：人类疾病的小鼠遗传模型。目前有一个爆炸的新的小鼠品系，模仿人类疾病的关键方面。因此，小鼠遗传模型正迅速成为解开人类疾病之谜的主要工具。不幸的是，老鼠的小尺寸带来了一个新的研究瓶颈-如何诊断比人类小4000倍的动物的疾病。在人类中，成像技术是诊断疾病的关键工具，但人类成像机器的设计并不能有效地评估像老鼠这样小的生物。因此，需要高度专业化的设备来研究人类疾病的小鼠模型。本申请的目的是获得一台Vevo 770，专门用于对小鼠和其他小动物进行超声成像研究。该设备的分辨率非常好，因此它的应用被指定为超声生物显微镜。超声生物显微镜检查将极大地增强NIH资助的达特茅斯医学院众多研究人员的研究;他们在包括心血管疾病、免疫系统调节、癌症生物学和神经系统疾病在内的广泛研究中使用小鼠。因此，Vevo 770将提供给所有达特茅斯的研究人员，使他们能够使用高分辨率的最先进的工具来研究人类疾病的小鼠模型。6B.心血管疾病、癌症和神经系统疾病是美国长期残疾和死亡的主要原因。这项应用需要一种成像仪器，使达特茅斯的研究人员能够更好地研究小鼠这些疾病的遗传基础。这些研究可能会导致许多新的策略，以改善这一广泛的疾病的诊断和治疗。

DESCRIPTION (provided by applicant): The recent ability to tailor make mice with specific genetic mutations has produced a new biomedical revolution: mouse genetic models of human disease. There is presently an explosion of novel mouse strains that mimic key aspects of human diseases. Thus, mouse genetic models are rapidly becoming a dominant tool to unlock the mysteries of human disease. Unfortunately the small size of the mouse introduces a new research bottle neck - how does one diagnose disease in an animal 4000 times smaller than a human. In humans, imaging techniques are a key tool to diagnose disease, but human imaging machines are not designed to effectively evaluate a creature as small as a mouse. Thus, highly specialize equipment will be required to study mouse models of human disease. The objective of this application is to obtain a Vevo 770, which is specifically designed to perform ultrasound imaging studies on mice and other small animals. The resolution of this equipment is so fine that it's application is designated as ultrasound biomicroscopy. Ultrasound biomicroscopy would dramatically enhance NIH funded research of numerous investigators at Dartmouth Medical School; who use mice in a wide range of studies that include cardiovascular disease, immune system regulation, cancer biology and neurologic diseases. Thus, the Vevo 770 would be made available to all Dartmouth investigators to empower them with a high resolution state-of-art tool for studying mouse models of human disease. 6B. Relevance Cardiovascular disease, cancer and neurologic diseases are major causes of long term disability and death in the United States. This application requests an imaging instrument that will enable Dartmouth investigators to better study the genetic basis of these diseases in mice. These studies may lead to numerous novel strategies to improve the diagnosis and treatment of this broad range of diseases.