Illumina BeadStation 500GX

Illumina BeadStation 500GX

• 批准号: 7216474
• 负责人: Sally A. Camper
• 金额: $ 46.51万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-15 至 2008-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7216474
• 关键词: Accounting; Address; Chromosome Mapping; Custom; Devices; Funding; Gene Expression; Genes; Genetic Research; Genotype; Hereditary Disease; Human; Human Genome; Michigan; Mus; RNA; Research; Research Personnel; Resources; Sampling; System; Universities; density; instrument; trait

DESCRIPTION (provided by applicant): To address a critical shortage of genotyping resources at the University of Michigan, we seek funding to purchase an Illumina BeadStation 500GX and accessories. With this instrument, we will be able to perform high-density genotyping on 300,000 SNPs in whole genome human samples. The instrument requested will also allow typing of custom panels of 384 or 1536 SNPs in either human or mouse, suitable for example for fine-mapping of genetic traits. Finally, the instrument will also be capable of performing gene expression analysis on human or mouse RNA isolates. We have identified a set of seven Major Users who have current NIH-funded projects that would be greatly facilitated by this device. They will account for at least 70% of the capacity of the system during the next 3 years. Other users are listed who are highly likely to make use of the instrument as well. Relevence: Understanding genetic diseases requires that the researcher identify the gene(s) involved. To do so requires genotyping, which was previously very laborious and has been a serious bottleneck in research. The requested instrument alleviates this bottleneck, greatly accelerating genetic research at the University of Michigan.

描述(申请人提供)：为了解决密歇根大学基因鉴定资源严重短缺的问题，我们寻求资金购买Illumina BeadStation 500GX及其配件。有了这台仪器，我们将能够对30万个全基因组人类样本中的SNPs进行高密度基因分型。所要求的仪器还将允许对人类或小鼠的384或1536个SNPs的定制面板进行打字，例如适用于精细绘制遗传特征图。最后，该仪器还将能够对人或鼠RNA分离株进行基因表达分析。我们已经确定了七个主要用户，他们目前拥有NIH资助的项目，该设备将极大地促进这些项目的实施。在未来3年内，它们将至少占系统容量的70%。列出了极有可能也使用该仪器的其他用户。简介：了解遗传病需要研究人员确定涉及的基因(S)。要做到这一点，需要进行基因分型，这在以前是非常费力的，一直是研究中的一个严重瓶颈。所要求的仪器缓解了这一瓶颈，极大地加快了密歇根大学的基因研究。