Purchase of a 500 MHz Solid State NMR Spectrometer

描述（由申请人提供）：我们建议购买一台500 MHz固态NMR（SSNMR）光谱仪，该光谱仪将用于密歇根大学生物物理学，化学，牙科和医学社区的生物医学研究。 在密歇根大学，研究人员利用SSNMR光谱获得有关不溶性和/或非结晶生物系统的结构，动力学，几何形状和相互作用的高分辨率信息。这些NIH资助的研究项目的进展受到阻碍，由于缺乏一个先进的高场SSNMR光谱仪。因此，此次收购将大大扩展SSNMR光谱的适用性，以研究项目，目前正在研究中，在我们的机构和核心的跨学科研究的新举措。 500 MHz光谱仪将用于研究膜相关蛋白质的高分辨率结构，调节RNA是开发抗HIV治疗剂的重要目标，以及多态性药物。此外，骨材料和肽抗生素和树枝状聚合物的膜相互作用的调查将显着受益于光谱仪的使用。 该仪器的所有主要用户都得到了NIH R 01赠款的支持。

DESCRIPTION (provided by applicant): We propose to purchase a 500 MHz solid-state NMR (SSNMR) spectrometer that will be used for biomedical research by the Biophysics, Chemistry, Dental and Medical communities at the University of Michigan. At the University of Michigan, researchers utilize SSNMR spectroscopy to obtain high-resolution information about the structure, dynamics, geometry and interactions of non-soluble and/or non-crystalline biological systems. Progress of these NIH-funded research projects is hampered due to lack of a sophisticated high field SSNMR spectrometer. Therefore, this purchase will significantly extend the applicability of SSNMR spectroscopy to research projects that are presently under study at our institution and nucleate new initiatives in interdisciplinary research. The 500 MHz spectrometer will be used to study the high-resolution structure of membrane-associated proteins, regulatory RNAs that are important targets for development of anti-HIV therapeutics, and polymorphic pharmaceutical drugs. In addition, investigation of bone materials and membrane interaction of peptide antibiotics and dendrimers will significantly benefit from the use of the spectrometer. All the major users of the instrument are supported by NIH R01 grants.