Fine-tuning dietary fibre to target gut microbiota accessibility

微调膳食纤维以改善肠道微生物群的可及性

• 批准号: 2890552
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2890552
• 关键词: Fine; tuning; dietary; fibre; target

The project will explore the bioaccessibility of prebiotic fibres from natural matrices and their accessibility to the human gut microbiota. Most of the evidence on the efficacy of prebiotics (fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS), arabinoxylan-oligosaccharides (AXOS)) has been collated using the extracted and highly refined oligomers. There is an increasing emphasis on minimally processed foods and moves away from highly refined materials would meet this need. Such minimal processing of natural plant-based starting materials which control the accessibility of the constituent oligomers might include fermentation, the use of enzymes, technologies such as pulse electric fields and thermo/physico mechanical pre-processing and the degree of ripening of the starting material. These processes will create changes in both the degree of polymerization of the 'parent' polysaccharide and the diffusivity of the oligosaccharides from the natural matrices - which fine-tunes accessibility of the fibre by the gut microbiota. This project will use models of the human gut microbiota combined with cutting-edge metabolomics and metagenomics to study the impact of processing of fibre on gut microbiota composition and microbial accessibility.The project therefore sits at the interface between physical sciences and microbiome science and will an innovative comparison of fibre sources and the extent to which they can be controlled through pre-processing, to measure the effect on in gut fermentation, and subsequent effects on the gut microbiota and metabolic markers.

该项目将探索来自天然矩阵的益生元纤维及其对人类肠道微生物群的可及性的生物恢复性。已经使用提取的且高度精制的低聚物对益生元（FOS），半含糖（GOS），Arabinoxylan-寡糖（AXOS）的疗效的大多数证据进行了。越来越强调最少加工的食物，并远离高度精制的材料将满足这种需求。自然基于植物的起始物质的最小处理可能控制组成寡聚的可及性，包括发酵，使用酶的使用，脉冲电场和Thermo/Physico机械预处理等技术以及起始材料的成熟程度。这些过程将在“父”多糖的聚合程度和寡糖从天然矩阵中的扩散率变化 - 肠道微生物群对纤维的可及性进行微调。该项目将使用人类肠道菌群的模型与尖端的代谢组学和宏基因组学相结合，以研究纤维对肠道菌群组成和微生物可及性的处理的影响。发酵以及随后对肠道微生物群和代谢标记的影响。