Extreme Longevity Family Study - DMCC

超长寿家庭研究 - DMCC

• 批准号: 7289620
• 负责人: Michael A. Province
• 金额: $ 14.57万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7289620
• 关键词: aging; chromosomes; clinical research; cooperative study; data management; disease /disorder etiology; family genetics; gene environment interaction; gene interaction; genetic screening; genetic susceptibility; genome; human subject; linkage disequilibriums; longevity

DESCRIPTION (provided by applicant): There is increasing evidence that exceptional longevity (EL) is a familial trait that is at least partially genetic, with a suggestive linkage found on chromosome 4 in a recent genome scan of centenarian sibships, and some studies finding association to selected candidate genes (e.g. inflammatory regulating genes, HLA, BRCA1). However, the magnitude of the genetic contribution is still controversial. The familial nature and exact contribution of its various correlated subphenotypes and "risk" factors is also not clear. There may be complex heterogeneity, gene by gene, gene by environment, temporal trends in operation. The overall objective of the Exceptional Longevity Family Study (ELFS) is to estimate and characterize the role of familial and genetic factors in the etiology of EL. Multiple field centers will recruit EL pedigrees using population based resources. As the Data Management and Coordinating Center (DMCC), we will provide critical logistical support, collaboration, and central expertise and leadership during the three critical phases of the study: finalization of design/protocol, data collection and analysis and publications.

描述（由申请人提供）：有越来越多的证据表明，特殊的寿命（EL）是一种家庭性状，至少部分是遗传的，在最近的百年同变的基因组基因组扫描中，在4号染色体上发现了具有暗示性的联系，并且一些研究发现与选定的候选基因相关（例如，炎症性基因（例如，炎症性基因）（例如，炎症性基因，hla，hla，hla，brca，brca1）。但是，遗传贡献的大小仍然存在争议。其各种相关亚表现型和“风险”因素的家族性质和确切贡献也不清楚。可能存在复杂的异质性，基因的基因，环境基因，操作中的时间趋势。特殊寿命家族研究（ELFS）的总体目标是估计和表征家族性和遗传因素在EL病因中的作用。多个野外中心将使用基于人群的资源招募El Eledigrees。作为数据管理和协调中心（DMCC），我们将在研究的三个关键阶段中提供关键的后勤支持，协作以及中心专业知识和领导力：设计/协议的最终化，数据收集，分析以及出版物的最终化。