CSHL 2023 Conference on Telomeres & Telomerase

冷泉港端粒和端粒酶实验室会议 2023年5月2日至6日 摘要 端粒是一种特殊的蛋白质-核酸复合体，它保护端粒末端 真核细胞的染色体。在大多数真核生物中，端粒包含短DNA重复序列 由端粒酶逆转录酶维持。人们很早就认识到 年龄和复制相关的端粒缩短是细胞和 生物体衰老过程，端粒长度和完整性是人类 寿命。短的或功能失调的端粒会导致细胞衰老或细胞死亡 是人类许多与年龄相关的病理的原因，从干细胞 功能障碍、认知障碍和痴呆症与癌症的年龄相关性增加 风险。端粒和端粒酶成分突变导致端粒加速 缩短，如观察到的先天性角化不良与年龄直接相关- 相关疾病和寿命缩短，强调了解的重要性 端粒功能对人类健康跨度和预防年龄相关性疾病的影响 病理学。因此，端粒领域现在是高度多样化和动态的， 代表了端粒在其中发挥关键作用的各种研究领域(衰老， 端粒综合征，干细胞，细胞周期进展，癌症，减数分裂和生育， 重组、复制)。该领域包括对老鼠和人类的研究 系统以及从各种不同的模式生物(鸟类、 青蛙、苍蝇、植物、线虫、原生动物、萌芽酵母、分裂酵母)。这次会议 重点了解端粒蛋白与细胞通路的相互作用 调节基因组完整性，关于端粒酶调节和 生物发生--端粒维持途径对衰老和不朽的调节 以及作为端粒长度、完整性和端粒长度函数的端粒依赖病理 生物年龄。 之前关于端粒和端粒的12次冷泉港实验室会议 端粒酶在将来自世界各地的不同研究人员聚集在一起方面起到了至关重要的作用 ，并导致了激烈的讨论和协同的互动 主要是受到未公布数据的公布的刺激。因为CSHL的端粒 而端粒酶会议仍然是科学家们在这一快速发展过程中的唯一机会 作为一个整体进行互动的领域不断扩大，这次会议是独一无二的，具有极其重要的意义 为了这一领域的未来。此外，CSHL会议的形式，几乎所有关于该会议的讨论 是从提交的摘要中选择的，最大限度地增加了新的独立 调查人员、博士后和研究生以高度可见的方式介绍他们的工作 会场。这些会议都有一个统一的高出席率的国际 一群研究人员，讲台和海报一直呈现着主要的 早在发表之前就有了这一领域的发现。

Cold Spring Harbor Laboratory Conference on Telomeres and Telomerase May 2–6, 2023 Abstract Telomeres are specialized protein-nucleic acid complexes that protect the ends of eukaryotic chromosomes. In most eukaryotes, telomeres contain short DNA repeats that are maintained by the telomerase reverse transcriptase. It has long been recognized that age and replication-associated telomere shortening is a driver of the cellular and organismal aging process, and that telomere length and integrity are regulators of human life span. Short or dysfunctional telomeres drive cells into senescence or cell death and are causative for numerous age-associated pathologies in humans, ranging from stem cell dysfunction, cognitive disorders and dementia to the age dependent increase in cancer risk. Mutations in telomere and telomerase components causing accelerated telomere shortening, such as observed in Dyskeratosis Congenita are directly associate with age- associated disorders and reduced lifespan, emphasizing the importance of understanding telomere function for the human health span and prevention of age-associated pathologies. As a result, the telomere field is now highly diverse and dynamic, representing a wide variety of research areas in which telomeres play crucial roles (aging, telomere syndromes, stem cells, cell cycle progression, cancer, meiosis and fertility, recombination, replication). The field encompasses research with mouse and human systems as well as insights gained from a wide variety of different model organisms (birds, frogs, flies, plants, nematodes, protozoa, budding yeast, fission yeast). This meeting focuses on understanding the interplay of telomeric proteins with cellular pathways that regulate genome integrity, on progress in the fields of telomerase regulation and biogenesis, on the regulation of aging and immortality by telomere maintenance pathways and on telomere dependent pathologies as function of telomere length, integrity and organismal age. The previous twelve Cold Spring Harbor Laboratory meetings on Telomeres and Telomerase have been crucial in bringing together a diverse group of researchers from all parts of the world, and have resulted in vigorous discussion and synergistic interactions stimulated by the presentation of mostly unpublished data. Because the CSHL Telomeres and Telomerase conference remains the only opportunity for scientists in this rapidly growing field to interact as a whole, this meeting is unique and of the utmost importance for the future of the field. Moreover, the format of CSHL meetings, for which nearly all talks are chosen from submitted abstracts, maximizes the opportunity for new independent investigators, postdocs and graduate students to present their work in a highly visible venue. These meetings have all had a uniformly high attendance rate from an international group of researchers, and the podium and posters have consistently presented the major discoveries in the field well before publication.