CSHL 2023 Conference on Telomeres & Telomerase

冷泉港端粒和端粒酶实验室会议 2023年5月2日至6日 摘要 端粒是一种特殊的蛋白质-核酸复合物， 真核生物染色体在大多数真核生物中，端粒含有短的DNA重复序列， 由端粒酶逆转录酶维持。人们早就认识到， 年龄和复制相关的端粒缩短是细胞和 端粒的长度和完整性是人体衰老过程的调节器， 寿命端粒短或功能失调会导致细胞衰老或细胞死亡， 是人类许多与年龄相关的病理学的病因， 功能障碍、认知障碍和痴呆与癌症的年龄依赖性增加有关 风险端粒和端粒酶组分的突变导致端粒加速 缩短，例如在先天性角化不良中观察到的缩短，与年龄直接相关， 相关疾病和寿命缩短，强调了解 端粒功能对人类健康的跨度和预防年龄相关的 病理学因此，端粒领域现在高度多样化和动态， 代表了端粒发挥关键作用的各种研究领域（衰老， 端粒综合征，干细胞，细胞周期进程，癌症，减数分裂和生育能力， 重组、复制）。该领域包括对小鼠和人类的研究 系统以及从各种不同的模式生物（鸟类， 青蛙、苍蝇、植物、线虫、原生动物、芽殖酵母、分裂酵母）。本次会议 侧重于了解端粒蛋白与细胞通路的相互作用， 调节基因组完整性，关于端粒酶调节和 通过端粒维持途径调节衰老和永生 以及作为端粒长度、完整性和 有机体年龄 前十二次冷泉港实验室关于端粒和 端粒酶在汇集来自世界各地的不同研究人员方面发挥了至关重要的作用。 世界各地，并导致了激烈的讨论和协同互动 由于大多数未公布的数据的呈现而受到刺激。因为CSHL端粒 端粒酶会议仍然是科学家们在这一领域迅速发展的唯一机会。 作为一个整体互动的日益增长的领域，这次会议是独一无二的，也是至关重要的 为了这个领域的未来。此外，CSHL会议的形式，几乎所有的会谈， 从提交的摘要中选择，最大限度地增加新的独立的机会， 研究人员，博士后和研究生在一个高度可见的 会场这些会议的出席率都很高， 一组研究人员，讲台和海报一贯提出的主要 在出版之前就在该领域有了发现。

Cold Spring Harbor Laboratory Conference on Telomeres and Telomerase May 2–6, 2023 Abstract Telomeres are specialized protein-nucleic acid complexes that protect the ends of eukaryotic chromosomes. In most eukaryotes, telomeres contain short DNA repeats that are maintained by the telomerase reverse transcriptase. It has long been recognized that age and replication-associated telomere shortening is a driver of the cellular and organismal aging process, and that telomere length and integrity are regulators of human life span. Short or dysfunctional telomeres drive cells into senescence or cell death and are causative for numerous age-associated pathologies in humans, ranging from stem cell dysfunction, cognitive disorders and dementia to the age dependent increase in cancer risk. Mutations in telomere and telomerase components causing accelerated telomere shortening, such as observed in Dyskeratosis Congenita are directly associate with age- associated disorders and reduced lifespan, emphasizing the importance of understanding telomere function for the human health span and prevention of age-associated pathologies. As a result, the telomere field is now highly diverse and dynamic, representing a wide variety of research areas in which telomeres play crucial roles (aging, telomere syndromes, stem cells, cell cycle progression, cancer, meiosis and fertility, recombination, replication). The field encompasses research with mouse and human systems as well as insights gained from a wide variety of different model organisms (birds, frogs, flies, plants, nematodes, protozoa, budding yeast, fission yeast). This meeting focuses on understanding the interplay of telomeric proteins with cellular pathways that regulate genome integrity, on progress in the fields of telomerase regulation and biogenesis, on the regulation of aging and immortality by telomere maintenance pathways and on telomere dependent pathologies as function of telomere length, integrity and organismal age. The previous twelve Cold Spring Harbor Laboratory meetings on Telomeres and Telomerase have been crucial in bringing together a diverse group of researchers from all parts of the world, and have resulted in vigorous discussion and synergistic interactions stimulated by the presentation of mostly unpublished data. Because the CSHL Telomeres and Telomerase conference remains the only opportunity for scientists in this rapidly growing field to interact as a whole, this meeting is unique and of the utmost importance for the future of the field. Moreover, the format of CSHL meetings, for which nearly all talks are chosen from submitted abstracts, maximizes the opportunity for new independent investigators, postdocs and graduate students to present their work in a highly visible venue. These meetings have all had a uniformly high attendance rate from an international group of researchers, and the podium and posters have consistently presented the major discoveries in the field well before publication.