VEGFR-1 and VEGFR-2 in angiogenesis
VEGFR-1 and VEGFR-2 in angiogenesis
批准号:
7032948
负责人:
Nader Rahimi
金额:
$31.54万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-04-01 至 2008-02-29
关键词:
angiogenesisbiological signal transductioncell linecell migrationcell proliferationdimergrowth factor receptorsligandsmitogen activated protein kinasepathologic processphosphorylationprotein protein interactionprotein structure functionreceptor bindingreceptor expressiontissue /cell culturetyrosinevascular endothelial growth factors
中文摘要
描述(由申请人提供):血管生成是一个重要的过程,
仅在正常发育中,但在病理条件下,
和转移。用于预防血管生成的新的和改进的方法需要一种
了解调节血管生成的机制。血管
内皮生长因子(VEGF)及其受体(VEGFR-lIFlt-1和
VEGFR-2/Flk-1/KDR)被认为是肿瘤诱导的细胞凋亡的主要调节因子。
血管生成VEGFR-2的激活刺激血管生成,而VEGFR- 1
激活似乎通过刺激血管生成
或抑制血管生成。因此,了解分子机制
这些截然不同的影响是发展的基础,
针对血管生成抑制的靶向治疗干预。
本提案的总体目标是调查
VEGFRS被激活并利用这些差异来抑制血管生成。
这一建议的重点是配体结合的机制,在这种情况下,
VEGF受体的激活,这是信号转导中的基本问题,
血管生成一旦我们确定了VEGF受体的作用机制,
将有可能减弱血管生成信号转导
通过开发针对血管生成的靶向治疗干预措施,
抑制
英文摘要
DESCRIPTION (Provided by applicant): Angiogenesis is an essential process not
only in normal development, but in pathological conditions such as tumor growth
and metastasis. New and improved methods for preventing angiogenesis require an
understanding of the mechanisms that regulate angiogenesis. Vascular
endothelial growth factor (VEGF) and its receptors (VEGFR-lIFlt-l and
VEGFR-2/Flk-1/KDR) are considered to be primary regulators of tumor-induced
angiogenesis. Activation of VEGFR-2 stimulates angiogenesis, while VEGFR- 1
activation appears to play a dual function by either stimulating angiogenesis
or suppressing angiogenesis. Therefore, understanding the molecular mechanisms
underlying these strikingly different effects is essential for development of
targeted therapeutic interventions aimed at angiogenesis suppression.
The overall goal of this proposal is to investigate the mechanism by which
VEGFRS are activated and to exploit these differences to suppress angiogenesis.
This proposal focuses on the mechanism by which ligand binding results in the
activation of VEGF receptors, a fundamental issue in signal transduction and
angiogenesis. Once we determine the mechanism by which VEGF receptors are
engaged it will be possible to attenuate the angiogenic signal transduction
relay by developing targeted therapeutic interventions aimed at angiogenesis
suppression
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1158/0008-5472.can-08-2905
发表时间:
2009-03-15
期刊:
Cancer research
影响因子:
11.2
作者:
[Rahimi N, Golde TE, Meyer RD]
通讯作者:
Meyer RD
DOI:
10.1111/tra.12353
发表时间:
2016-03
期刊:
Traffic (Copenhagen, Denmark)
影响因子:
--
作者:
[Maghsoudlou A, Meyer RD, Rezazadeh K, Arafa E, Pudney J, Hartsough E, Rahimi N]
通讯作者:
Rahimi N
Overcoming the resistance to anti-angiogenesis therapy
-
批准号:8814348
-
项目类别:
-
资助金额:$21.36万
-
财政年份:2014
-
负责人:Nader Rahimi
-
依托单位:
IDENTIFICATION OF PHOSPHORYLATION SITES ON TUMOR CELL INVASION PROTEIN
-
批准号:8365581
-
项目类别:
-
资助金额:$0.46万
-
财政年份:2011
-
负责人:Nader Rahimi
-
依托单位:
POTENTIAL ROLE OF BETA-TRCP1 UBIQUITIN E3 LIGASE IN ANGIOGENESIS
-
批准号:8365582
-
项目类别:
-
资助金额:$0.31万
-
财政年份:2011
-
负责人:Nader Rahimi
-
依托单位:
Role of Protein Ubiquitination in Angiogenesis
-
批准号:7915459
-
项目类别:
-
资助金额:$40.22万
-
财政年份:2008
-
负责人:Nader Rahimi
-
依托单位:
Role of Protein Ubiquitination in Angiogenesis
-
批准号:7678404
-
项目类别:
-
资助金额:$40.63万
-
财政年份:2008
-
负责人:Nader Rahimi
-
依托单位:
Role of Protein Ubiquitination in Angiogenesis
-
批准号:7464819
-
项目类别:
-
资助金额:$40.63万
-
财政年份:2008
-
负责人:Nader Rahimi
-
依托单位:
Anti-angiogenic signaling molecules in retinal cells
-
批准号:6415729
-
项目类别:
-
资助金额:$16.21万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
VEGFR-1 and VEGFR-2 in angiogenesis
-
批准号:6623853
-
项目类别:
-
资助金额:$31.97万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
Anti-angiogenic signaling molecules in retinal cells
-
批准号:6708856
-
项目类别:
-
资助金额:$16.15万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
VEGFR-1 and VEGFR-2 in angiogenesis
-
批准号:6470500
-
项目类别:
-
资助金额:$31.76万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
VEGFR-1 and VEGFR-2 in angiogenesis
-
批准号:6867320
-
项目类别:
-
资助金额:$32.3万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
VEGFR-1 and VEGFR-2 in angiogenesis
-
批准号:6732646
-
项目类别:
-
资助金额:$31.78万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
Anti-angiogenic signaling molecules in retinal cells
-
批准号:6620332
-
项目类别:
-
资助金额:$16.15万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
海外基金