VEGFR-1 and VEGFR-2 in angiogenesis
VEGFR-1 and VEGFR-2 in angiogenesis
批准号:
7032948
负责人:
Nader Rahimi
金额:
$31.54万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-04-01 至 2008-02-29
关键词:
angiogenesisbiological signal transductioncell linecell migrationcell proliferationdimergrowth factor receptorsligandsmitogen activated protein kinasepathologic processphosphorylationprotein protein interactionprotein structure functionreceptor bindingreceptor expressiontissue /cell culturetyrosinevascular endothelial growth factors
中文摘要
描述(由申请人提供):血管生成是一个重要的过程,而不是
仅在正常发育中,但在肿瘤生长等病理条件下
和转移。预防血管生成的新的和改进的方法需要
了解调节血管生成的机制。血管
内皮生长因子 (VEGF) 及其受体 (VEGFR-lIFlt-l 和
VEGFR-2/Flk-1/KDR)被认为是肿瘤诱导的主要调节因子
血管生成。 VEGFR-2 的激活刺激血管生成,而 VEGFR-1 的激活
激活似乎通过刺激血管生成发挥双重功能
或抑制血管生成。因此,了解分子机制
这些显着不同的影响的背后对于发展至关重要
旨在抑制血管生成的有针对性的治疗干预措施。
该提案的总体目标是研究机制
VEGFR 被激活并利用这些差异来抑制血管生成。
该提案重点关注配体结合导致
VEGF 受体的激活,信号转导的一个基本问题
血管生成。一旦我们确定了 VEGF 受体的作用机制
参与将有可能减弱血管生成信号转导
通过开发针对血管生成的有针对性的治疗干预措施来接力
镇压
英文摘要
DESCRIPTION (Provided by applicant): Angiogenesis is an essential process not
only in normal development, but in pathological conditions such as tumor growth
and metastasis. New and improved methods for preventing angiogenesis require an
understanding of the mechanisms that regulate angiogenesis. Vascular
endothelial growth factor (VEGF) and its receptors (VEGFR-lIFlt-l and
VEGFR-2/Flk-1/KDR) are considered to be primary regulators of tumor-induced
angiogenesis. Activation of VEGFR-2 stimulates angiogenesis, while VEGFR- 1
activation appears to play a dual function by either stimulating angiogenesis
or suppressing angiogenesis. Therefore, understanding the molecular mechanisms
underlying these strikingly different effects is essential for development of
targeted therapeutic interventions aimed at angiogenesis suppression.
The overall goal of this proposal is to investigate the mechanism by which
VEGFRS are activated and to exploit these differences to suppress angiogenesis.
This proposal focuses on the mechanism by which ligand binding results in the
activation of VEGF receptors, a fundamental issue in signal transduction and
angiogenesis. Once we determine the mechanism by which VEGF receptors are
engaged it will be possible to attenuate the angiogenic signal transduction
relay by developing targeted therapeutic interventions aimed at angiogenesis
suppression
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1158/0008-5472.can-08-2905
发表时间:
2009-03-15
期刊:
Cancer research
影响因子:
11.2
作者:
[Rahimi N, Golde TE, Meyer RD]
通讯作者:
Meyer RD
DOI:
10.1111/tra.12353
发表时间:
2016-03
期刊:
Traffic (Copenhagen, Denmark)
影响因子:
--
作者:
[Maghsoudlou A, Meyer RD, Rezazadeh K, Arafa E, Pudney J, Hartsough E, Rahimi N]
通讯作者:
Rahimi N
Overcoming the resistance to anti-angiogenesis therapy
-
批准号:8814348
-
项目类别:
-
资助金额:$21.36万
-
财政年份:2014
-
负责人:Nader Rahimi
-
依托单位:
IDENTIFICATION OF PHOSPHORYLATION SITES ON TUMOR CELL INVASION PROTEIN
-
批准号:8365581
-
项目类别:
-
资助金额:$0.46万
-
财政年份:2011
-
负责人:Nader Rahimi
-
依托单位:
POTENTIAL ROLE OF BETA-TRCP1 UBIQUITIN E3 LIGASE IN ANGIOGENESIS
-
批准号:8365582
-
项目类别:
-
资助金额:$0.31万
-
财政年份:2011
-
负责人:Nader Rahimi
-
依托单位:
Role of Protein Ubiquitination in Angiogenesis
-
批准号:7915459
-
项目类别:
-
资助金额:$40.22万
-
财政年份:2008
-
负责人:Nader Rahimi
-
依托单位:
Role of Protein Ubiquitination in Angiogenesis
-
批准号:7678404
-
项目类别:
-
资助金额:$40.63万
-
财政年份:2008
-
负责人:Nader Rahimi
-
依托单位:
Role of Protein Ubiquitination in Angiogenesis
-
批准号:7464819
-
项目类别:
-
资助金额:$40.63万
-
财政年份:2008
-
负责人:Nader Rahimi
-
依托单位:
Anti-angiogenic signaling molecules in retinal cells
-
批准号:6415729
-
项目类别:
-
资助金额:$16.21万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
VEGFR-1 and VEGFR-2 in angiogenesis
-
批准号:6623853
-
项目类别:
-
资助金额:$31.97万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
Anti-angiogenic signaling molecules in retinal cells
-
批准号:6708856
-
项目类别:
-
资助金额:$16.15万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
VEGFR-1 and VEGFR-2 in angiogenesis
-
批准号:6470500
-
项目类别:
-
资助金额:$31.76万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
VEGFR-1 and VEGFR-2 in angiogenesis
-
批准号:6867320
-
项目类别:
-
资助金额:$32.3万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
VEGFR-1 and VEGFR-2 in angiogenesis
-
批准号:6732646
-
项目类别:
-
资助金额:$31.78万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
Anti-angiogenic signaling molecules in retinal cells
-
批准号:6620332
-
项目类别:
-
资助金额:$16.15万
-
财政年份:2002
-
负责人:Nader Rahimi
-
依托单位:
海外基金