Genetics of autoimmune gastritis

自身免疫性胃炎的遗传学

• 批准号: nhmrc : 329203
• 负责人: Dr Thomas Brodnicki
• 金额: $ 19.2万
• 依托单位: James Cook University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetics-autoimmune-gastritis/100771
• 关键词: Genetics; autoimmune; gastritis

Autoimmune diseases are those caused by the body's immune system attacking the body's own tissues. One group of autoimmune diseases, termed the thyrogastric cluster appear to share genetic risk factors, because they tend to occur together - either in the same patient, or else in families. Some of the diseases within the thyrogastric cluster are known to be very complex genetically, while others appear to be much less complex. Furthermore, some animal models of autoimmune diease are genetically simpler still. We have chosen to study the genetics of gastritis in mice that have had their thymuses removed on the third day of life, because this model has relatively few genes involved; we have found that only 4 genes affect the risk of disease. This means that it will give us the optimum chance of identfiying at least one of these genes. The methods used involve both selective breeding techniques and generating special gene transfer mice in which individuals from one strain will carry the inserted genes from another. In this way, we can identify exactly which genes affect the risk of disease. Once identified, the gene sequences will help us determine if the same gene plays a role in human disease, and if so, to develop new diagnostic tests and therapies.

自身免疫性疾病是由人体免疫系统攻击自身组织而引起的疾病。有一组自身免疫性疾病，称为甲胃簇，似乎有共同的遗传风险因素，因为它们往往一起发生--要么发生在同一个患者身上，要么发生在家族中。众所周知，甲状腺胃簇中的一些疾病在基因上非常复杂，而其他疾病似乎没有那么复杂。此外，一些自身免疫性疾病的动物模型在基因上更加简单。我们选择研究生后第三天切除胸腺的小鼠的胃炎遗传学，因为这个模型涉及的基因相对较少；我们发现只有4个基因影响疾病风险。这意味着它将给我们提供识别这些基因中至少一个的最佳机会。使用的方法既包括选择育种技术，也包括产生特殊的基因转移小鼠，在这种小鼠中，来自一个品系的个体将携带来自另一个品系的插入基因。通过这种方式，我们可以准确地识别哪些基因会影响疾病风险。一旦确定，基因序列将帮助我们确定相同的基因是否在人类疾病中发挥作用，如果是，则开发新的诊断测试和治疗方法。