Developing new therapeutic strategies for ALT positive sarcomas

开发 ALT 阳性肉瘤的新治疗策略

• 批准号: 2893230
• 金额: --
• 依托单位: Institute of Cancer Research
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2893230
• 关键词: Developing; new; therapeutic; strategies; ALT

Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism that is enriched in mesenchymal cancers such as sarcomas. This dependency on ALT presents opportunities for identifying new vulnerabilities in this group of rare cancers. Focusing on soft tissue sarcomas, in this project the student will use a combination of high content imaging screens and proteomic analysis to identify emerging drug targets in the DNA damage response and replication stress pathways that are selective for ALT-positive cancers. This project has the potential to define new therapeutic strategies for the treatment of patients with ALT-positive sarcomas.

端粒的替代性延长（ALT）是一种端粒维持机制，在间充质癌如肉瘤中富集。这种对ALT的依赖性为识别这组罕见癌症中的新脆弱性提供了机会。专注于软组织肉瘤，在这个项目中，学生将使用高含量的成像屏幕和蛋白质组学分析的组合，以确定在DNA损伤反应和复制应激途径，是ALT阳性癌症的选择性新兴药物靶标。该项目有可能为ALT阳性肉瘤患者的治疗确定新的治疗策略。