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Effective connectivity of central response to Irritable Bowel Syndrome (IBS)

肠易激综合症 (IBS) 中央响应的有效连接

基本信息

批准号：
7245049
负责人：
JENNIFER S LABUS
金额：
$ 12.07万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7245049
关键词：
Acoustics Address Affective Amygdaloid structure Analysis of Variance Anxiety Area Arts Attention Autonomic nervous system Behavioral Biometry Brain Brain Stem Brain imaging Brain region Chronic Chronic Kidney Failure Clinical Clinical Research Cognitive Complex Condition Cues Data Data Analyses Data Set Databases Depth Development Dimensions Disease Disease model Doctor of Philosophy Down-Regulation Emotional Esthesia Evoked Potentials Experimental Designs Faculty Female Fibromyalgia Fright Functional Gastrointestinal Disorders Functional Magnetic Resonance Imaging Functional disorder Gastroenterologist Generations Goals Health Health Psychology Heart Rate Hypersensitivity Imaging Techniques Individual Individual Differences Inflammatory Bowel Diseases Investigation Irritable Bowel Syndrome Knowledge Lateral Least-Squares Analysis Link Measures Mediating Mentored Clinical Scientist Award Mentors Methods Modeling Neural Network Simulation Neuraxis Neuroanatomy Neurobiology Neurosciences Pain Pain Disorder Patients Pattern Peripheral Physiological Positron-Emission Tomography Post-Traumatic Stress Disorders Prevalence Principal Investigator Process Psychophysiology Quality of life Range Recurrent pain Reflex action Reporting Research Research Design Research Methodology Research Personnel Research Support Resolution Rest Science Scientist Series Solid Specificity Statistical Models Stimulus Stress Structure Symptoms System Techniques Technology Testing Time Time Series Analysis Training Visceral Visceral pain Visit Women&apos s Health analytical tool attentional modulation biopsychosocial career chronic depression design improved innovation interest male member midbrain central gray substance mind body interaction network models novel pain inhibition patient oriented research programs psychologic regional difference response skills statistics vigilance

项目摘要

DESCRIPTION (provided by applicant): Although there is a rapidly expanding technology for assessing central and autonomic nervous system activity in irritable bowel syndrome (IBS) using techniques such as fMRI and modulation of the startle reflex, large and complex data sets are generated that render conventional statistical approaches of limited applicability and have increased the need for more sophisticated analytic strategies. Research scientists trained in both the substantive knowledge in the field as well as the application and development of state-of-the-art and emerging statistical techniques for data analysis are essential to successful advancements in the science of functional gastrointestinal (GI) disorders. Currently, few functional GI disorder researchers have this dual training. The goal of this Mentored Clinical Scientist Award is to develop a research program applying state of the art analysis and design techniques to functional brain imaging and psychophysiological studies in functional GI disorders. An emerging biopsychosocial disease model for IBS posits underlying alterations in central nervous system mechanisms involved in stress and fear. The primary aim of the research is to improve understanding of central processes in functional GI disorders through better statistical analysis and network modeling with particular attention toward fMRI and experimental psychophysiological studies (including startle paradigms and evoked-response potentials). The research focus is on the application of neural network modeling approaches to complex data sets obtained with different brain imaging techniques, and to relate these results to simultaneously obtained psychological, behavioral, autonomic measures. The training plan involves the acquisition, development and application of novel quantitative methods such as effective connectivity modeling and mixed-effects modeling for fMRI and psychophysiological data and includes coursework and mentored training in neuroscience, neurobiology of brain-gut interactions, advanced biostatistics, neuroengineering, and clinical research in IBS. The proposed research plan which includes new analyses of extensive existing and ongoing study databases,and two new neuropsychophysiological studies will provide the candidate an opportunity to investigate the neuroanatomical and pathophysiologic substrates of the cognitive, behavioral, affective and physiologic alterations observed in health and disease with major implications for IBS and related functional disorders.

描述（由申请人提供）：