Effective connectivity of central response to Irritable Bowel Syndrome (IBS)

肠易激综合症 (IBS) 中央响应的有效连接

基本信息

批准号：
7245049
负责人：
JENNIFER S LABUS
金额：
$ 12.07万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7245049
关键词：
Acoustics Address Affective Amygdaloid structure Analysis of Variance Anxiety Area Arts Attention Autonomic nervous system Behavioral Biometry Brain Brain Stem Brain imaging Brain region Chronic Chronic Kidney Failure Clinical Clinical Research Cognitive Complex Condition Cues Data Data Analyses Data Set Databases Depth Development Dimensions Disease Disease model Doctor of Philosophy Down-Regulation Emotional Esthesia Evoked Potentials Experimental Designs Faculty Female Fibromyalgia Fright Functional Gastrointestinal Disorders Functional Magnetic Resonance Imaging Functional disorder Gastroenterologist Generations Goals Health Health Psychology Heart Rate Hypersensitivity Imaging Techniques Individual Individual Differences Inflammatory Bowel Diseases Investigation Irritable Bowel Syndrome Knowledge Lateral Least-Squares Analysis Link Measures Mediating Mentored Clinical Scientist Award Mentors Methods Modeling Neural Network Simulation Neuraxis Neuroanatomy Neurobiology Neurosciences Pain Pain Disorder Patients Pattern Peripheral Physiological Positron-Emission Tomography Post-Traumatic Stress Disorders Prevalence Principal Investigator Process Psychophysiology Quality of life Range Recurrent pain Reflex action Reporting Research Research Design Research Methodology Research Personnel Research Support Resolution Rest Science Scientist Series Solid Specificity Statistical Models Stimulus Stress Structure Symptoms System Techniques Technology Testing Time Time Series Analysis Training Visceral Visceral pain Visit Women&apos s Health analytical tool attentional modulation biopsychosocial career chronic depression design improved innovation interest male member midbrain central gray substance mind body interaction network models novel pain inhibition patient oriented research programs psychologic regional difference response skills statistics vigilance

项目摘要

DESCRIPTION (provided by applicant): Although there is a rapidly expanding technology for assessing central and autonomic nervous system activity in irritable bowel syndrome (IBS) using techniques such as fMRI and modulation of the startle reflex, large and complex data sets are generated that render conventional statistical approaches of limited applicability and have increased the need for more sophisticated analytic strategies. Research scientists trained in both the substantive knowledge in the field as well as the application and development of state-of-the-art and emerging statistical techniques for data analysis are essential to successful advancements in the science of functional gastrointestinal (GI) disorders. Currently, few functional GI disorder researchers have this dual training. The goal of this Mentored Clinical Scientist Award is to develop a research program applying state of the art analysis and design techniques to functional brain imaging and psychophysiological studies in functional GI disorders. An emerging biopsychosocial disease model for IBS posits underlying alterations in central nervous system mechanisms involved in stress and fear. The primary aim of the research is to improve understanding of central processes in functional GI disorders through better statistical analysis and network modeling with particular attention toward fMRI and experimental psychophysiological studies (including startle paradigms and evoked-response potentials). The research focus is on the application of neural network modeling approaches to complex data sets obtained with different brain imaging techniques, and to relate these results to simultaneously obtained psychological, behavioral, autonomic measures. The training plan involves the acquisition, development and application of novel quantitative methods such as effective connectivity modeling and mixed-effects modeling for fMRI and psychophysiological data and includes coursework and mentored training in neuroscience, neurobiology of brain-gut interactions, advanced biostatistics, neuroengineering, and clinical research in IBS. The proposed research plan which includes new analyses of extensive existing and ongoing study databases,and two new neuropsychophysiological studies will provide the candidate an opportunity to investigate the neuroanatomical and pathophysiologic substrates of the cognitive, behavioral, affective and physiologic alterations observed in health and disease with major implications for IBS and related functional disorders.

描述（由申请人提供）：尽管有一项快速扩展的技术，该技术用于评估肠易激综合征（IB）（IBS）的中枢和自主神经系统活动，并使用诸如fMRI和惊吓反射的调制等技术生成了大型且复杂的数据集，这些数据集是生成有限适用性的传统统计方法，并增加了对更多成熟分析策略的需求。在该领域的实质知识以及最先进和新兴的统计技术中，对数据分析的实质性知识进行了培训，这对于功能性胃肠道（GI）疾病科学方面都是必不可少的。目前，功能性GI障碍研究人员进行了这种双重培训。这项指导的临床科学家奖的目标是制定一项研究计划，该计划将技术分析和设计技术应用于功能性GI疾病的功能性脑成像和心理生理学研究。 IBS的新兴生物心理社会疾病模型提出了涉及压力和恐惧的中枢神经系统机制的基础改变。这项研究的主要目的是通过更好地统计分析和网络建模来提高对功能性胃肠道疾病中的中心过程的了解，并特别注意fMRI和实验心理生理学研究（包括惊吓范式和诱发的反应潜力）。研究重点是将神经网络建模方法应用于使用不同的大脑成像技术获得的复杂数据集的应用，并将这些结果与同时获得心理，行为，自主性措施相关联。该培训计划涉及对fMRI和心理生理数据的有效连通性建模和混合效应建模等新型定量方法的获取，开发和应用，包括在神经科学上进行课程工作以及脑外形相互作用的神经生物学的课程培训，先进的生物统计学，神经工具和临床研究。拟议的研究计划包括对广泛现有和正在进行的研究数据库的新分析，两项新的神经心理生理学研究将为候选人提供一个机会，以研究在与IBS和IBS和Realistial Dissorders和Realistial Dissorders的认知，行为，情感和生理变化的认知，行为，情感和生理变化的认知，行为，情感和生理变化中的神经解剖学和病理生理基础。